Passivation of high-surface-energy sites of milled ibuprofen crystals via dry coating for reduced cohesion and improved flowability

Journal of Pharmaceutical Sciences

Volumn 102, Issue 7, 2013, Pages 2282-2296

  Han, Xi ^a   Jallo, Laila ^a   To, Daniel ^a   Ghoroi, Chinmay ^b   Davé, Rajesh ^a  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^b INDIAN INSTITUTE OF TECHNOLOGY GANDHINAGAR   (India)

Author keywords

Dry particle coating; Formulation; Inverse gas chromatography; Milling; Powder technology; Solid state; Surface chemistry; Surface energy heterogeneity

Indexed keywords

IBUPROFEN; SILICON DIOXIDE;

ADHESION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISPERSION; DRUG COATING; DRUG DOSAGE FORM COMPARISON; ENERGY; EQUIPMENT; FLOW KINETICS; INVERSE GAS CHROMATOGRAPHY; LASER DIFFRACTION; PARTICLE SIZE; PASSIVE TRANSPORT; POWDER; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY;

EID: 84879030146     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23589     Document Type: Article

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