Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4342-4350

  Amano, Yohei ^a   Noguchi, Masayuki ^a   Nakagomi, Madoka ^a   Muratake, Hideaki ^a   Fukasawa, Hiroshi ^a   Shudo, Koichi ^a  

^a Kawasaki   (Japan)

Author keywords

Agonist; Amide; Bulky hydrophobic fragment; RAR; Retinoid

Indexed keywords

2 CHLORO 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 2 CHLORO 4 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 2 FLUORO 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 2 FLUORO 4 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 2 HYDROXY 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 2 METHOXY 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]BENZOIC ACID; 4 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 4 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]BENZOIC ACID; 4 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]BENZOIC ACID; 4 [13 ([10]METACYCLOPHANYL)CARBAMOYL]BENZOIC ACID; 4 [13 ([10]METACYCLOPHANYL)CARBOXAMIDO]BENZOIC ACID; 5 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]PYRIDINE 2 CARBOXYLIC ACID; 5 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]THIOPHENE 2 CARBOXYLIC ACID; 5 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]PYRIDINE 2 CARBOXYLIC ACID; 5 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]THIOPHENE 2 CARBOXYLIC ACID; 5 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]PYRIDINE 2 CARBOXYLIC ACID; 5 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]THIOPHENE 2 CARBOXYLIC ACID; 5 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]PYRIDINE 2 CARBOXYLIC ACID; 5 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]THIOPHENE 2 CARBOXYLIC ACID; 6 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]NICOTINIC ACID; 6 [(5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]NICOTINIC ACID; 6 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBAMOYL]NICOTINIC ACID; 6 [(6A METHYL 5,6,6A,7,8,9 HEXAHYDRO 4H 2 PHENALENYL)CARBOXAMIDO]NICOTINIC ACID; AROMATIC COMPOUND; BENZOHEPTALENE DERIVATIVE; METACYCLOPHANE DERIVATIVE; PHENALENE DERIVATIVE; RETINOID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION;

CELL DIFFERENTIATION; DRUG DESIGN; HL-60 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS;

EID: 84879026917     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.053     Document Type: Article

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