Suicide commitment with metformin: Our experience with five cases

Renal Failure

Volumn 35, Issue 6, 2013, Pages 863-865

  Avci, Deniz ^a   Çetinkaya, Ali ^a   Karahan, Samet ^a   Oǧuzhan, Nilüfer ^b   Karagöz, Hatice ^a   Başak, Mustafa ^a   Erden, Abdulsamet ^a  

^a Kayseri Eǧitim Araştirma Hastanesi ^*  (Turkey)

^b ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

Hemodialysis; High anion gap metabolic acidosis; Lactic acidosis; Metformin; Suicide attempt

Indexed keywords

ACTIVATED CARBON; ALANINE AMINOTRANSFERASE; ALCOHOL; AMITRIPTYLINE; DICLOFENAC; GLUCOSE; HYDROCHLOROTHIAZIDE PLUS TELMISARTAN; LACTIC ACID; METFORMIN; RUPATADINE;

ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALKALOSIS; ARTERIAL GAS; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; BLOOD PRESSURE; BREATHING RATE; CARBON DIOXIDE TENSION; CARDIOVERSION; CLINICAL ARTICLE; DRUG INTOXICATION; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEART RATE; HEART VENTRICLE TACHYCARDIA; HEMODIALYSIS; HUMAN; INTENSIVE CARE UNIT; INTERNAL MEDICINE; LACTATE BLOOD LEVEL; LETHARGY; MAJOR DEPRESSION; MALE; NAUSEA; PHYSICAL EXAMINATION; POOR GENERAL CONDITION; PRIORITY JOURNAL; RESUSCITATION; STOMACH LAVAGE; SUICIDE ATTEMPT; VOMITING;

ADOLESCENT; ADULT; FATAL OUTCOME; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 84879021063     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2013.801299     Document Type: Article

References (14)

1. Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996;334: 574-579 (Pubitemid 126537875)
2. Campbell IW, Howlett HC. Worldwide experience of metformin as an effective glucose-lowering agent: A meta-Analysis. Diabetes Metab Rev. 1995;11(Suppl 1):57-62
3. Chang CT, Chen YC, Fang JT, Huang CC. Metformin-Associated lactic acidosis: Case reports and literature review. J Nephrol. 2002; 15:398-402
4. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131:281-303 (Pubitemid 29383658)
5. Stang MR, Wysowski DK, Butler-Jones D. Incidence of lactic acidosis in metformin users. Diabetes Care. 1999;22:925-927 (Pubitemid 29241046)
6. Cusi K, Consoli A, DeFronzo RA. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996;81:4059-4067 (Pubitemid 26380418)
7. Sulkin TV, Bosman D, Krentz AJ. Contraindications to metformin therapy in patients with NIDDM. Diabetes Care. 1997;20:925-928 (Pubitemid 27224940)
8. Chang CT, Chen YC, Fang JT, Huang CC. High anion gap metabolic acidosis in suicide: Don't forget metformin intoxicationtwo patients' experiences. Ren Fail. 2002;24(5):671-675
9. Bronstein A, Spyker D, Cantilena L, et al. 2006 Annual report of the American Association of Poison Control Centers National Poison Data System (NPDS) 25th annual report. Clin Toxicol. 2007; 45:815-917
10. Lalau JD, Mourhlhon C, Bergeret A, et al. Consequences of metformin intoxication. Diabetes Care. 1998;21:2036-2037
11. Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348:607-614 (Pubitemid 30410251)
12. El-Mir MY, Nogueira V, Fontaine E, et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 2000;275:223-228 (Pubitemid 30038975)
13. Garber AJ. Metformin: Mechanisms of antihyperglycemic action, other pharmacodynamic properties, and safety perspectives. Endocr Pract. 1997;3(6):359-370
14. Gong L, Goswami S, Giacomini KM, et al. Metformin pathways: Pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012;22(11):820-827