Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3- dihydroindol-2-ones and studies on their mechanisms of action

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 603-612

  Andreani, Aldo ^a   Granaiola, Massimiliano ^a   Locatelli, Alessandra ^a   Morigi, Rita ^a   Rambaldi, Mirella ^a   Varoli, Lucilla ^a   Vieceli Dalla Sega, Francesco ^a   Prata, Cecilia ^a   Nguyen, Tam L ^b   Bai, Ruoli ^c   Hamel, Ernest ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SAIC FREDERICK INC   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

Antiproliferative activity; Knoevenagel reaction; NADPH oxidase 4; Oxindole; Tubulin assembly

Indexed keywords

3 (3,4,5 TRIMETHOXYBENZYLIDENE) 1,3 DIHYDROINDOL 2 ONE; BENZYLIDENE DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY;

ANTINEOPLASTIC AGENTS; BENZYLIDENE COMPOUNDS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84879011564     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.033     Document Type: Article

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