Emodin prevents ethanol-induced developmental anomalies in cultured mouse fetus through multiple activities

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 98, Issue 3, 2013, Pages 268-275

  Yon, Jung Min ^a   Lin, Chunmei ^a   Oh, Ki Wan ^a   Baek, Hong Seok ^b   Lee, Beom Jun ^a   Yun, Young Won ^a   Nam, Sang Yoon ^a  

^a Chungbuk National University   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Emodin; Ethanol; Prevention; Teratogenesis; Whole embryo culture

Indexed keywords

ALCOHOL; CASPASE 3; COPPER ZINC SUPEROXIDE DISMUTASE; EMODIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MANGANESE SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY HEIGHT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DRUG ACTIVITY; EMBRYO CULTURE; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FETUS; MALE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; RAT; RHAMNUS; TERATOGENESIS; YOLK SAC;

RHAMNACEAE; RHAMNUS;

EID: 84878984490     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21061     Document Type: Article

References (45)

1. Akers KG, Kushner SA, Leslie AT, Clarke L, van der Kooy D, Lerch JP, Frankland PW. 2011. Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. Mol Brain 4:29.
2. Antonio AM, Gillespie RA, Druse-Manteuffel MJ. 2011. Effects of lipoic acid on antiapoptotic genes in control and ethanol-treated fetal rhombencephalic neurons. Brain Res 1383:13-21.
3. Baek IJ, Yon JM, Lee BJ, Yun YW, Yu WJ, Hong JT, Ahn B, Kim YB, Kim DJ, Kang JK, Nam SY. 2005. Expression pattern of cytosolic glutathione peroxidase (cGPx) mRNA during mouse embryogenesis. Anat Embryol (Berl) 209(4):315-321.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Brocardo PS, Gil-Mohapel J, Christie BR. 2011. The role of oxidative stress in fetal alcohol spectrum disorders. Brain Res Rev 67(1-2):209-225.
6. Cano MJ, Ayala A, Murillo ML, Carreras O. 2001. Protective effect of folic acid against oxidative stress produced in 21-day postpartum rats by maternal-ethanol chronic consumption during pregnancy and lactation period. Free Radic Res 34(1):1-8.
7. Church MW, Abel EL, Kaltenbach JA, Overbeck GW. 1996. Effects of prenatal alcohol exposure and aging on auditory function in the rat: preliminary results. Alcohol Clin Exp Res 20(1):172-179.
8. Cohen-Kerem R, Koren G. 2003. Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans. Neurotoxicol Teratol 25(1):1-9.
9. Dang SS, Zhang X, Jia XL, Cheng YA, Song P, Liu EQ, He Q, Li ZF. 2008. Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats. Chin Med J (Engl.) 121(11):1010-1014.
10. Ding Y, Zhao L, Mei H, Zhang SL, Huang ZH, Duan YY, Ye P. 2008. Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Eur J Pharmacol 590(1-3):377-386.
11. Drever N, Yin H, Kechichian T, Costantine M, Longo M, Saade GR, Bytautiene E. 2012. The expression of antioxidant enzymes in a mouse model of fetal alcohol syndrome. Am J Obstet Gynecol 206(4):e319-322.
12. Flohe L, Gunzler WA, Schock HH. 1973. Glutathione peroxidase: a selenoenzyme. FEBS Lett 32(1):132-134.
13. Fridovich I. 1986. Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 58:61-97.
14. Hancock ML, Miller RR. 2006. Resveratrol can only partially attenuate ethanol-induced oxidative stress in embryonic chick brains. Nutr Neurosci 9(3-4):121-129.
15. Huang Q, Lu G, Shen HM, Chung MC, Ong CN. 2007. Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev 27(5):609-630.
16. Jones KL. 2011. The effects of alcohol on fetal development. Birth Defects Res C Embryo Today 93(1):3-11.
17. Jung KY, Yon JM, No KO, Lin C, Jung AY, Lee JG, Jung KY, Lee BJ, Yun YW, Nam SY. 2010. Expression pattern of phospholipid hydroperoxide glutathione peroxidase mRNA during mouse fetal organ development. J Biomed Res 11(4):235-242.
18. Juranek I, Bezek S. 2005. Controversy of free radical hypothesis: reactive oxygen species-cause or consequence of tissue injury? Gen Physiol Biophys 24(3):263-278.
19. Kim MR, Lee KN, Yon JM, Lee SR, Jin Y, Baek IJ, Lee BJ, Yun YW, Nam SY. 2008. Capsaicin prevents ethanol-induced teratogenicity in cultured mouse whole embryos. Reprod Toxicol 26(3-4):292-297.
20. Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC. 2008. Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function. Circ Res 103(10):1139-1146.
21. Lee BH, Huang YY, Duh PD, Wu SC. 2012. Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury. Pharm Biol 50(3):351-359.
22. Lin C, Yon JM, Jung AY, Lee JG, Jung KY, Kang JK, Lee BJ, Yun YW, Nam SY. 2012. Resveratrol prevents nicotine-induced teratogenesis in cultured mouse embryos. Reprod Toxicol 34(3):340-346.
23. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402-408.
24. McCord JM, Fridovich I. 1969. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244(22):6049-6055.
25. Mills GC. 1957. Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown. J Biol Chem 229(1):189-197.
26. New DA. 1978. Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev Camb Philos Soc 53(1):81-122.
27. Ng TB, Liu F, Lu Y, Cheng CH, Wang Z. 2003. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp Biochem Physiol C Toxicol Pharmacol 136(2):109-115.
28. Ojeda ML, Nogales F, Jotty K, Barrero MJ, Murillo ML, Carreras O. 2009. Dietary selenium plus folic acid as an antioxidant therapy for ethanol-exposed pups. Birth Defects Res B Dev Reprod Toxicol 86(6):490-495.
29. Qian ZJ, Zhang C, Li YX, Je JY, Kim SK, Jung WK. 2011. Protective effects of emodin and chrysophanol isolated from marine fungus Aspergillus sp. on ethanol-induced toxicity in HepG2/CYP2E1 cells. Evid Based Complement Alternat Med 2011:452621.
30. Rugh R. 1990. The mouse: its reproduction and development. Oxford Science Publications, New York. p 102-153.
31. Ryan HE, Lo J, Johnson RS. 1998. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17(11):3005-3015.
32. Singh KB, Trigun SK. 2011. Apoptosis of Dalton's lymphoma due to in vivo treatment with emodin is associated with modulations of hydrogen peroxide metabolizing antioxidant enzymes. Cell Biochem Biophys [Epub ahead of print].
33. Tiwari V, Kuhad A, Chopra K. 2010. Epigallocatechin-3-gallate ameliorates alcohol-induced cognitive dysfunctions and apoptotic neurodegeneration in the developing rat brain. Int J Neuropsychopharmacol 13(8):1053-1066.
34. Tufan AC, Satiroglu-Tufan NL. 2003. The effect of ethanol exposure on extraembryonic vascular development in the chick area vasculosa. Cells Tissues Organs 175:84-97.
35. Valles SL, Blanco AM, Pascual M, Guerri C. 2004. Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol 14(4):365-371.
36. Van Maele-Fabry G, Delhaise F, Picard JJ. 1990. Morphogenesis and quantification of the development of post-implantation mouse embryos. Toxicol In Vitro 4(2):149-156.
37. Wang X, Zou Y, Sun A, Xu D, Niu Y, Wang S, Wang K, Ge J. 2007. Emodin induces growth arrest and death of human vascular smooth muscle cells through reactive oxygen species and p53. J Cardiovasc Pharmacol 49(5):253-260.
38. Webster WS, Abela D. 2007. The effect of hypoxia in development. Birth Defects Res C 81(3):215-228.
39. Wentzel P, Eriksson UJ. 2006. Ethanol-induced fetal dysmorphogenesis in the mouse is diminished by high antioxidative capacity of the mother. Toxicol Sci 92(2):416-422.
40. Wentzel P, Rydberg U, Eriksson UJ. 2006. Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat. Alcohol Clin Exp Res 30(10):1752-1760.
41. Wu Y, Tu X, Lin G, Xia H, Huang H, Wan J, Cheng Z, Liu M, Chen G, Zhang H, Fu J, Liu Q, Liu DX. 2007. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Life Sci 81(17-18):1332-1338.
42. Yon JM, Baek IJ, Lee SR, Jin Y, Kim MR, Nahm SS, Kim JS, Ahn B, Lee BJ, Yun YW, Nam SY. 2008. The spatio-temporal expression pattern of cytoplasmic Cu/Zn superoxide dismutase (SOD1) mRNA during mouse embryogenesis. J Mol Histol 39(1):95-103.
43. Yon JM, Baek IJ, Lee BJ, Yun YW, Nam SY. 2011a. Dynamic expression of manganese superoxide dismutase during mouse embryonic organogenesis. Int J Dev Biol 55(3):327-334.
44. Yon JM, Baek IJ, Lee BJ, Yun YW, Nam SY. 2011b. Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1alpha and intracellular superoxide dismutases. Reprod Toxicol 31(4):513-518.
45. Yon JM, Baek IJ, Lee SR, Kim MR, Hong JT, Yong H, Lee BJ, Yun YW, Nam SY. 2012. Protective effect of [6]-gingerol on the ethanol-induced teratogenesis of cultured mouse embryos. Arch Pharm Res 35(1):171-178.