Urethane increases reactive oxygen species and activates extracellular signal-regulated kinase in RAW 264.7 macrophages and A549 lung epithelial cells

Archives of Pharmacal Research

Volumn 36, Issue 6, 2013, Pages 775-782

  Chun, So Hee ^a   Cha, Young Nam ^a   Kim, Chaekyun ^a  

^a Inha University School of Medicine   (South Korea)

Author keywords

ERK; Heme oxygenase; Reactive oxygen species; Tumor; Urethane

Indexed keywords

ACETYLCYSTEINE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; URETHAN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CARCINOGENESIS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACETYLCYSTEINE; ANESTHETICS, INTRAVENOUS; ANIMALS; CELL LINE; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEME OXYGENASE-1; HUMANS; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; REACTIVE OXYGEN SPECIES; URETHANE;

EID: 84878965702     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0104-8     Document Type: Article

References (38)

1. Allavena, P.; C. Garlanda, M.G. Borrello, A. Sica, and A. Mantovani. 2008. Pathways connecting inflammation and cancer. Current Opinion in Genetics & Development 18: 3-10. (Pubitemid 351694444)
2. Azad, N.; A.K. Iyer, A. Manosroi, L. Wang, and Y. Rojanasakul. 2008a. Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis. Carcinogenesis 29: 1538-1545.
3. Azad, N.; Y. Rojanasakul, and V. Vallyathan. 2008b. Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. Journal of Toxicology and Environmental Health Part B Critical Reviews. 11: 1-15.
4. Balansky, R.M.; and S. De Flora. 1998. Chemoprevention by N-acetylcysteine of urethane-induced clastogenicity and lung tumors in mice. International Journal of Cancer 77: 302-305. (Pubitemid 28287985)
5. Chan, D.W.; V.W. Liu, G.S. Tsao, K.M. Yao, T. Furukawa, K.K. Chan, and H.Y. Ngan. 2008. Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis 29: 1742-1750.
6. Cooper, K.L.; K.J. Liu, and L.G. Hudson. 2009. Enhanced ROS production and redox signaling with combined arsenite and UVA exposure: contribution of NADPH oxidase. Free Radical Biology and Medicine 47: 381-388.
7. Coussens, L.M.; and Z. Werb. 2002. Inflammation and cancer. Nature 420: 860-867. (Pubitemid 36019639)
8. De Flora, S.; M. Astengo, D. Serra, and C. Bennicelli. 1986. Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine. Cancer Letters 32: 235-241. (Pubitemid 16030481)
9. Doris, K.; S.P. Karabela, C.A. Kairi, D.C. Simoes, C. Roussos, S.G. Zakynthinos, I. Kalomenidis, T.S. Blackwell, and G.T. Stathopoulos. 2010. Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice. Respiratory Research 11: 118.
10. Faux, S.P.; T. Tai, D. Thorne, Y. Xu, D. Breheny, and M. Gaca. 2009. The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke. Biomarkers 14(Suppl 1): 90-96.
11. Hamilton Jr, R.F.; S.A. Thakur, and A. Holian. 2008. Silica binding and toxicity in alveolar macrophages. Free Radical Biology and Medicine 44: 1246-1258.
12. Hanausek, M.; Z. Walaszek, A. Viaje, M. LaBate, E. Spears, D. Farrell, R. Henrich, A. Tveit, E.F. Walborg Jr, and T.J. Slaga. 2004. Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential. Carcinogenesis 25: 431-437. (Pubitemid 38344411)
13. Karoor, V.; M. Le, D. Merrick, E.C. Dempsey, and Y.E. Miller. 2010. Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors. Cancer Prevention Research 3: 1141-1147.
14. Kim, C.; J.S. Jang, M.R. Cho, S.R. Agarawal, and Y.N. Cha. 2010. Taurine chloramine induces heme oxygenase-1 expression via Nrf2 activation in murine macrophages. International Immunopharmacology 10: 440-446.
15. Kim, J.W.; and C. Kim. 2005. Inhibition of LPS-induced NO production by taurine chloramine in macrophages is mediated through Ras-ERK-NF-kappaB. Biochemical Pharmacology 70: 1352-1360. (Pubitemid 41383471)
16. Liu, L.Z.; Y. Jiang, R.L. Carpenter, Y. Jing, S.C. Peiper, and B.H. Jiang. 2011. Role and mechanism of arsenic in regulating angiogenesis. PLoS ONE 6: e20858.
17. McCubrey, J.A.; M.M. Lahair, and R.A. Franklin. 2006. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxidants & Redox Signaling 8: 1775-1789. (Pubitemid 44726351)
18. Nettleship, A.; P. Henshaw, and H. Meyer. 1943. Induction of pulmonary tumors in mice with ethyl carbamate (urethane). Journal of the National Cancer Institute 4: 309-319.
19. Nomura, T. 1975. Urethan (ethyl carbamate) as a cosolvent of drugs commonly used parenterally in humans. Cancer Research 35: 2895-2899.
20. Nomura, T. 1982. Parental exposure to X-rays and chemicals induces heritable tumours and anomalies in mice. Nature 296: 575-577. (Pubitemid 12058406)
21. Nomura, T. 2008. Transgenerational effects from exposure to environmental toxic substances. Mutation Research 659: 185-193.
22. O'Donnell, E.P.; L.K. Zerbe, L.D. Dwyer-Nield, L.R. Kisley, and A.M. Malkinson. 2006. Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis. Cancer Letters 241: 197-202. (Pubitemid 44163033)
23. Orosz, Z.; A. Csiszar, N. Labinskyy, K. Smith, P.M. Kaminski, P. Ferdinandy, M.S. Wolin, A. Rivera, and Z. Ungvari. 2007. Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation. American Journal of Physiology Heart and Circulatory Physiology 292: H130-H139. (Pubitemid 46105172)
24. Penza, M.; C. Montani, M. Jeremic, G. Mazzoleni, W.L. Hsiao, M. Marra, H. Sharma, and D. Di Lorenzo. 2007. MAK-4 and -5 supplemented diet inhibit liver carcinogenesis in mice. BMC Complementary and Alternative Medicine 7: 19. (Pubitemid 47018672)
25. -/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clinical Cancer Research 17: 753-761.
26. Rinehart, J.; A.A. Adjei, P.M. Lorusso, D. Waterhouse, J.R. Hecht, R.B. Natale, O. Hamid, M. Varterasian, P. Asbury, E.P. Kaldjian, S. Gulyas, D.Y. Mitchell, R. Herrera, J.S. Sebolt-Leopold, and M.B. Meyer. 2004. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. Journal of Clinical Oncology 22: 4456-4462. (Pubitemid 41185111)
27. Roomi, M.W.; N.W. Roomi, T. Kalinovsky, M. Rath, and A. Niedzwiecki. 2009. Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice. Tumori 95: 508-513.
28. Rosin, F.C.; J.F. Pedregosa, J.S. de Almeida, and V. Bueno. 2011. Identification of myeloid-derived suppressor cells and T regulatory cells in lung microenvironment after urethane-induced lung tumor. International Immunopharmacology 11: 873-878.
29. Salinas, N.R.; C.T. Lopes, P.V. Palma, C.T. Oshima, and V. Bueno. 2009. Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. Pathology & Oncology Research 15: 549-554.
30. Saunders, J.A.; L.C. Rogers, C. Klomsiri, L.B. Poole, and L.W. Daniel. 2010. Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells. Free Radical Biology and Medicine 49: 2058-2067.
31. Singh, R.P.; G. Deep, M. Chittezhath, M. Kaur, L.D. Dwyer-Nield, A.M. Malkinson, and R. Agarwal. 2006. Effect of silibinin on the growth and progression of primary lung tumors in mice. Journal of the National Cancer Institute 98: 846-855. (Pubitemid 43923441)
32. Stathopoulos, G.T.; T.P. Sherrill, D.S. Cheng, R.M. Scoggins, W. Han, V.V. Polosukhin, L. Connelly, F.E. Yull, B. Fingleton, and T.S. Blackwell. 2007. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 104: 18514-18519. (Pubitemid 350210728)
33. Torres, M.; and H.J. Forman. 2003. Redox signaling and the MAP kinase pathways. BioFactors 17: 287-296. (Pubitemid 37267162)
34. Walser, T.; X. Cui, J. Yanagawa, J.M. Lee, E. Heinrich, G. Lee, S. Sharma, and S.M. Dubinett. 2008. Smoking and lung cancer: the role of inflammation. Proceedings of the American Thoracic Society 5: 811-815.
35. Yano, T.; S. Yajima, K. Hagiwara, I. Kumadaki, Y. Yano, S. Otani, M. Uchida, and T. Ichikawa. 2000. Vitamin E inhibits cell proliferation and the activation of extracellular signal-regulated kinase during the promotion phase of lung tumorigenesis irrespective of antioxidative effect. Carcinogenesis 21: 2129-2133.
36. Yano, T.; Y. Yano, Y. Nagashima, M. Yuasa, S. Yajima, S. Horikawa, K. Hagiwara, M. Kishimoto, T. Ichikawa, and S. Otani. 1999. Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen. Life Sciences 64: 229-236. (Pubitemid 29049306)
37. Yao, H.; I. Edirisinghe, S. Rajendrasozhan, S.R. Yang, S. Caito, D. Adenuga, and I. Rahman. 2008. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. American Journal of Physiology Lung Cellular and Molecular Physiology 294: L1174-L1186.
38. Zaynagetdinov, R.; T.P. Sherrill, V.V. Polosukhin, W. Han, J.A. Ausborn, A.G. McLoed, F.B. McMahon, L.A. Gleaves, A.L. Degryse, G.T. Stathopoulos, F.E. Yull, and T.S. Blackwell. 2011. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. Journal of Immunology 187: 5703-5711.