Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages

  Jiang, Dawei ^a,b,c   Zhao, Linlin ^a,b,c   Clish, Clary B ^d   Clapham, David E ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Calcium signaling; Epilepsy; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIPORTER; CALCIUM; GLUCOSE; HYDROGEN; LEUCINE ZIPPER EF HAND CONTAINING TRANSMEMBRANE PROTEIN 1; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; KAINIC ACID; LETM1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; PROTON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DISEASE COURSE; EMBRYO DEATH; EMBRYO DEVELOPMENT; GENE DELETION; GENE SILENCING; GLUCOSE METABOLISM; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; WOLF HIRSCHHORN SYNDROME; ANIMAL; ANIMAL EMBRYO; BRAIN; CALCIUM SIGNALING; CELL CULTURE; CELL STRAIN HEK293; CHEMICALLY INDUCED DISORDER; CONFOCAL MICROSCOPY; CYTOLOGY; ELECTRON MICROSCOPY; EPILEPSY; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; RNA INTERFERENCE; ULTRASTRUCTURE;

MUS; VASCONCELLEA CANDICANS;

CALCIUM SIGNALING; EPILEPSY; MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIPORTERS; BRAIN; CALCIUM; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; EMBRYO, MAMMALIAN; FEMALE; GLUCOSE; HEK293 CELLS; HUMANS; KAINIC ACID; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTONS; RNA INTERFERENCE; SEIZURES; WOLF-HIRSCHHORN SYNDROME;

EID: 84878961842     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308558110     Document Type: Article

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