Astaxanthin supplementation does not augment fat use or improve endurance performance

Medicine and Science in Sports and Exercise

Volumn 45, Issue 6, 2013, Pages 1158-1165

  Res, Peter T ^a   Cermak, Naomi M ^a   Stinkens, Rudi ^a   Tollakson, T J ^b   Haenen, Guido R ^a   Bast, Aalt ^a   Van Loon, Luc J C ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

anti oxidants; cycling; ergogenic AIDS; exercise; fat oxidation; substrate use

Indexed keywords

ANTIOXIDANT; ASTAXANTHIN; BIOLOGICAL MARKER; FATTY ACID; PERFORMANCE ENHANCING SUBSTANCE; XANTHOPHYLL;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ATHLETE; BICYCLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION; DRUG EFFECT; ENDURANCE; HUMAN; MALE; METABOLISM; NORMAL HUMAN; OXIDATION REDUCTION REACTION; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALYSIS OF VARIANCE; ANTIOXIDANTS; ATHLETES; BICYCLING; BIOLOGICAL MARKERS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FATTY ACIDS, NONESTERIFIED; HEALTHY VOLUNTEERS; HUMANS; MALE; OXIDATION-REDUCTION; PERFORMANCE-ENHANCING SUBSTANCES; PHYSICAL ENDURANCE; XANTHOPHYLLS;

EID: 84878942577     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31827fddc4     Document Type: Article

References (33)

1. Adriaens MP, Schoffelen PF, Westerterp KR. Intra-individual variation of basal metabolic rate and the influence of daily habitual physical activity before testing. Br J Nutr. 2003;90(2):419-23.
2. Andersen LP, Holck S, Kupcinskas L, et al. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol Med Microbiol. 2007; 50(2):244-8.
3. Aoi W, Naito Y, Sakuma K, et al. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 2003;5(1):139-44.
4. Aoi W, Naito Y, Takanami Y, et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem Biophys Res Commun. 2008;366: 892-7.
5. Beelen M, Berghuis J, Bonaparte B, Ballak SB, Jeukendrup AE, van Loon LJ. Carbohydrate mouth rinsing in the fed state: lack of enhancement of time-trial performance. Int J Sport Nutr Exerc Metab. 2009;19(4):400-9.
6. Bergstrom J, Hermansen L, Hultman E, Saltin B. Diet, muscle glycogen and physical performance. Acta Physiol Scand. 1967; 71(2):140-50.
7. Borg G. Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling strength test. Int J Sports Med. 1982;3(3):153-8.
8. Camera E, Mastrofrancesco A, Fabbri C, et al. Astaxanthin, can-thaxanthin and beta-carotene differently affect UVA-induced oxi-dative damage and expression of oxidative stress-responsive enzymes. Exp Dermatol. 2009;18(3):222-31.
9. Choi HD, Kim JH, Chang MJ, Kyu-Youn Y, Shin WG. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Res. 2011;25(12):1813-8.
10. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66(4):363-9.
11. Earnest CP, Lupo M, White KM, Church TS. Effect of astaxanthin on cycling time trial performance. Int J Sports Med. 2011;32(11): 882-8.
12. Fischer MA, Gransier TJ, Beckers LM, Bekers O, Bast A, Haenen GR. Determination of the antioxidant capacity in blood. Clin Chem Lab Med. 2005;43(7):735-40.
13. Goedecke JH, Christie C, Wilson G, et al. Metabolic adaptations to a high-fat diet in endurance cyclists. Metabolism. 1999;48(12): 1509-17.
14. Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008;44(2):126-31.
15. Hama S, Takahashi K, Inai Y, et al. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. J Pharm Sci. 2012;101(8):2909-16.
16. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astax-anthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull. 2006;29(10):2106-10.
17. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astax-anthin in obese mice fed a high-fat diet. Biosci Biotechnol Bio-chem. 2007;71(4):893-9.
18. Jeukendrup A, Saris WH, Brouns F, Kester AD. A new validated endurance performance test. Med Sci Sports Exerc. 1996;28(2): 266-70.
19. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond). 2010;7:65.
20. Karppi J, Rissanen TH, Nyyssonen K, et al. Effects of astaxanthin supplementation on lipid peroxidation. Int J Vitam Nutr Res. 2007; 77(1):3-11.
21. Kuipers H, Verstappen FT, Keizer HA, Geurten P, van Kranenburg G. Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med. 1985;6(4):197-201.
22. McGarry JD, Brown NF. The mitochondrial carnitine palmitoyl-transferase system. From concept to molecular analysis. Eur J Biochem. 1997;244(1):1-14.
23. Mercke Odeberg J, Lignell A, Pettersson A, Hoglund P. Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations. Eur J Pharm Sci. 2003;19(4):299-304.
24. Mortensen A, Skibsted LH, Truscott TG. The interaction of dietary carotenoids with radical species. Arch Biochem Biophys. 2001;385(1):13-9.
25. Naguib YM. Antioxidant activities of astaxanthin and related car-otenoids. J Agric Food Chem. 2000;48(4):1150-4.
26. Ohgami K, Shiratori K, Kotake S, et al. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol Vis Sci. 2003;44(6):2694-701.
27. Peronnet F, Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci. 1991;16(1):23-9.
28. Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med. 2008;44(2):153-9.
29. Schenk S, Horowitz JF. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab. 2006;291(2):E254-60.
30. Suganuma K, Nakajima H, Ohtsuki M, Imokawa G. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metallopro-teinase-1 and skin fibroblast elastase in human dermal fibroblasts. J Dermatol Sci. 2010;58(2):136-42.
31. Takahashi K, Watanabe M, Takimoto T, Akiba Y. Uptake and distribution of astaxanthin in several tissues and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin. Br Poult Sci. 2004;45(1):133-8.
32. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr. 2008;87(3):778-84.
33. Yang Y, Seo JM, Nguyen A, et al. Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. J Nutr. 2011;141(9):1611-7.