Metabolic adaptations to a high-fat diet in endurance cyclists

Metabolism: Clinical and Experimental

Volumn 48, Issue 12, 1999, Pages 1509-1517

  Goedecke, Julia H ^a   Christie, Candice ^b   Wilson, Gary ^b   Dennis, Steven C ^b   Noakes, Timothy D ^b   Hopkins, William G ^b   Lambert, Estelle V ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE ACETYLTRANSFERASE; GLUCOSE;

ADAPTATION; ADULT; ARTICLE; CONTROLLED STUDY; CYCLING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HUMAN EXPERIMENT; LIPID DIET; MALE; METABOLISM; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0032755163     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90238-X     Document Type: Article

References (43)

1. Bergstrom JL, Hermansen L, Hultman E, et al: Diet, muscle glycogen and physical performance. Acta Physiol Scand 71:140-150, 1967
2. Ahlborg BJ, Bergstrom J, Brohult J, et al: Human muscle glycogen content and capacity for prolonged exercise after different diets. Forvarsmedicin 3:85-99, 1967
3. Bosch AN, Dennis SC, Noakes TD: Influence of carbohydrate loading on fuel substrate turnover and oxidation during prolonged exercise. J Appl Physiol 74:1921-1927, 1993
4. Richter EA, Galbo H: High glycogen levels enhance glycogen breakdown in isolated contracting skeletal muscle. J Appl Physiol 61:827-831, 1986
5. Bosch AN, Dennis SC, Noakes TD: Influence of carbohydrate ingestion on fuel substrate turnover and oxidation during prolonged exercise. J Appl Physiol 76:2364-2374, 1994
6. Conlee RK, Hammer RL, Winder WW, et al: Glycogen repletion and exercise endurance in rats adapted to a high fat diet. Metabolism 39:289-294, 1990
7. Miller WC, Bryce GR, Conlee RK: Adaptations to a HFD that increase exercise endurance in male rats. J Appl Physiol 56:78-83, 1984
8. Simi B, Sempore B, Mayet M, et al: Additive effects of training and HFD on energy metabolism during exercise. J Appl Physiol 71:197-203, 1991
9. Lapachet RAB, Miller WC, Arnall DA: Body fat and exercise endurance in trained rats adapted to a high-fat and/or high-carbohydrate diet. J Appl Physiol 80:1173-1179, 1996
10. Phinney SD, Bistrian BR, Evans WJ, et al: The human metabolic response to chronic ketosis without caloric restriction: Preservation of submaximal exercise capacity with reduced carbohydrate oxidation. Metabolism 32:769-776, 1983
11. Jansson E, Kaijser L: Effect of diet on the utilization of blood-borne and intramuscular substrates during exercise in man. Acta Physiol Scand 115:19-30, 1982
12. Lambert EV, Speechly DP, Dennis SC, et al: Enhanced endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet. Eur J Appl Physiol 69:287-293, 1994
13. Cheng B, Karamizrak O, Noakes TD, et al: Time course of the effects of a high-fat diet and voluntary exercise on muscle enzyme activity in Long-Evans rats. Physiol Behav 61:701-705, 1997
14. Fisher EC, Evans WJ, Phinney SD, et al: Changes in skeletal muscle metabolism induced by eucaloric ketogenic diet, in Knuttger HG, Vogel JA, Poontaman J (eds): Biochemistry of Exercise. Champaign, IL, Human Kinetics, 1983, pp 497-501
15. Helge JW, Kiens B: Muscle enzyme activity in humans: Role of substrate availability and training. Am J Physiol 272:R1620-R1624, 1997
16. Kraegen EW, Clark PW, Jenkins AB, et al: Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40:1397-1403, 1991
17. Rosholt MN, King PA, Horton ES: HFD reduces glucose transporter responses to both insulin and exercise. Am J Physiol 266:R95-R101, 1994
18. Kim Y, Tamura T, Iwashita S, et al: Effect of HFD on gene expression of Glut4 and insulin receptor in soleus muscle. Biochem Biophys Res Commun 202:519-526, 1994
19. Bosch AN, Dennis SC, Noakes TD: Underestimation of substrate oxidation during exercise due to failure to account for bicarbonate kinetics. J Appl Physiol 75:2342-2343, 1993
20. Jackson AS, Pollock ML: Generalized equations for predicting body density of men. Br J Nutr 40:497-504, 1978
21. Hawley JA, Noakes TD: Peak sustained power output predicts VO2max and performance time in trained cyclists. Eur J Appl Physiol Occup Physiol 65:79-83, 1992
22. Palmer GS, Dennis SC, Noakes TD, et al: Assessment of the reproducibility of performance testing on an air-braked cycle ergometer. Int J Sports Med 17:293-298, 1996
23. van Zyl CG, Lambert EV, Hawley JA, et al: Effects of medium-chain triglyceride ingestion on fuel metabolism and cycling performance. J Appl Physiol 80:2217-2225, 1996
24. Sherrer S, Heidemann B, Kupfer A, et al: Hepatic metabolism of amino pyrine in patients with chronic renal failure. Clin Sci (Colch) 54:133-144, 1978
25. Bergmeyer HU (ed): Methods in Enzymatic Analysis. New York, NY, Academic, 1974
26. Costill DL, Bennet A, Branham G, et al: Glucose ingestion at rest and during prolonged exercise. J Appl Physiol 34:764-769, 1973
27. Coggan AR, Habash DL, Mendenhall LA, et al: Isotopic estimation of CO2 production during exercise before and after endurance training. J Appl Physiol 75:70-75, 1993
28. Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634, 1983
29. Bergstrom J: Muscle electrolytes in man. Scand J Clin Lab Invest Suppl 68:1-47, 1962
30. Evans WJ, Phinney SD, Young VR: Suction applied to muscle biopsy maximizes sample size. Med Sci Sports Exerc 14:101-102, 1982
31. Crabtree B, Newsholme EA: The activities of lipases and carnitine palmitoyl transferase in muscles from vertebrates and invertebrates. Biochem J 130:697-705, 1972
32. Bass A, Brdiczka D, Eyer P, et al: Metabolic differentiation of distinct muscle types at the level of enzymatic organization. Eur J Biochem 10:198-206, 1969
33. Srere PA: Citrate synthase. Methods Enzymol 13:3-11, 1969
34. Cutler DL, Gray CG, Park SW, et al: Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects. Metabolism 44:1264-1270, 1995
35. Oshida Y, Yamanouchi K, Hayamizu S, et al: Effects of training and training cessation on insulin action. Int J Sports Med 12:484-486, 1991
36. Heine RJ, Mulder C, Popp-Snijders C, et al: Linoleic-acidenriched diet: Long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients. Am J Clin Nutr 49:448-456, 1989
37. Jones NL, Heigenhauser GJF, Kuksis A, et al: Fat metabolism in heavy exercise. Clin Sci (Colch) 59:469-478, 1980
38. Helge JW, Wulff B, Kiens B: Impact of a fat-rich diet on endurance in man: Role of the dietary period. Med Sci Sports Exerc 30:456-461, 1998
39. Helge JW, Richter EA, Kiens B: Interaction of training and diet on metabolism and endurance during exercise in man. J Physiol (Lond) 492:293-306, 1996
40. Hawley JA, Brouns F, Jeukendrup AE: Strategies to enhance fat utilization during exercise. Sports Med 25:241-257, 1998
41. Goedecke JH, Elmer-English R, Dennis SC, et al: Effects of medium-chain triacylglycerol ingested with carbohydrate on metabolism and exercise performance. Int J Sport Nutr 9:65-77, 1999
42. Weltan SM, Bosch AN, Dennis SC, et al: Influence of muscle glycogen content on metabolic regulation. Am J Physiol 274:E72-E82, 1998
43. Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56:831-838, 1984