Antihyperlipidemic effects of ginger extracts in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in (rats)

Pharmacognosy Research

Volumn 5, Issue 3, 2013, Pages 157-161

  Al Noory, Ahmad Sameer ^a   Amreen, Abdul Nasser ^a   Hymoor, Shatha ^a  

^a DAMASCUS UNIVERSITY   (Syrian Arab Republic)

Author keywords

Alloxan induced diabetes; Atorvastatin; ginger; glibenclamide; lipoproteins

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; CHOLESTEROL; GINGER EXTRACT; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; GINGER; GLUCOSE BLOOD LEVEL; HYPOTHYROIDISM; LIPID BLOOD LEVEL; MALE; NONHUMAN; PROPYLTHIOURACIL HYPOTHYROIDISM; RANK SUM TEST; RAT;

EID: 84878929056     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.112419     Document Type: Article

References (33)

1. Elshater A, Salman M, Moussa M. Effect of ginger extract consumption on levels of blood glucose, lipid profile and kidney function in Alloxan induced-diabetic rats. Egypt Acad J Biolog Sci 2009;2:153-62.
2. Brunton L, Goodman LS, Donald B, Buxton L. Thyroid and antithyroid drugs. In: Laurence LB, Lazo JS, Parder KL, editors. Goodman and Gilmans' Manual of Pharmacology and Therapeutics. New York: McGraw-Hill; 2007. p. 986.
3. Zachariah TJ. Ginger. In: Parthasarathy VA, Champakam B, Zachariah TG, editors. Chemistry of Spices. CABI; 2008. p. 70-100.
4. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological, and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008;46:409-20.
5. Shen CL, Hong KJ, Kim SW. Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthritic cartilage explants. J Med Food 2003;6:323-8.
6. Mascolo N, Jain R, Jain SC, Capasso F. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol 1989;27:129-40.
7. Bhandari U, Sharma JN, Zafar R. The protective action of ethanolic ginger extract in cholesterol-fed rabbits. J Ethnopharmacol 1998;61:167-71.
8. Fuhrman B, Rosenblant M, Hayek T, Coleman R, Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic lipoprotein E-deficient mice. J Nutr 2000;130:1124-31.
9. Tanabe M, Chen YD, Saito K, Kano Y. Cholesterol biosynthes inhibitory component from Zingiber officinale Roscoe.Chem Pharm Bull (Tokyo) 1993;41:710-3.
10. Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger in streptozotocin-induced diabetic rats. Br J Nutr 2006;96:660-6
11. Sanavi S, Afshar R. Subacute thyroiditis following ginger (Zingiber officinale) consumption. Int J Ayurveda Res 2010;1:47-8.
12. Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J 2008;29:1280-4.
13. Bhandari U, Kanojia R, Pillai KK. Effect of etanolic extract of Zingiber officinale on dyslipidemia in diabetic rats. J Ethnopharmacol 2005;97:227-30.
14. Zhang J, Huang Y, Hou T, Wang Y. Hypoglycaemic effect of Artemisia sphaerocephala Krasch seed polysaccharide in alloxan-induced diabetic rats. Swiss Med Wkly 2006;136:529-32.
15. Laezza C, Mazziotti G, Fiorentino L, Gazzero P, Portella G, Gerbasio D, et al. HMG-CoA reductase inhibitor inhibit rat proyithiouracil-induced goiter by modulating the ras-MAPK pathway. J Mol Med (Berl) 2006;84:967-73.
16. Paget GF, Barnes JM. Toxicity test. In: Laurence DR, Bacharach AL, editors. Evaluation of Drug Activities: Pharmacometries. London: Academic Press; 1964. p. 135-66.
17. NIH Guide for the Care and Use of Laboratory Animals. (a) DHEW Publication No. (NIH) 8-23, revised 1978 and (b) NIH Publication No. 85-23, revised 1985. US Department of Health, Education, and Welfare.
18. Melianita F, Cholifah S, Sumarlik E, Kartinasari WF. Simultaneous densitometric determination of 6-gingerol and 6-shogaol in some commercial gingers. J Liquid Chrom Relat Tech 2007;30:2941-51.
19. Darweesh RM. Mann-Whitny U test in Statistical tests in psychology Damascus University Publication; 1997. p. 38-45.
20. Srinivasan K, Sambaiah K. The effect spices on cholesterol 7 alpha-hydroxylase activity on serum and on hepatic cholesterol levels in rat. Int J Vitam Nutr Res 1991;61:364-9.
21. Ness GC, Zhao Z, Lopez D. Inhibitor of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. Arch Biochem Biophys 1991;325:242-8.
22. Durrington P. Dyslipidaemia. Lancet 2003;362:717-31.
23. Cardia G, Grisorio D, Impedovo G, Lillo A, Regina G. Plasma lipid as a risk factor in peripheral vascular disease. Angiology 1990;41:19-22.
24. Murcia MA, Egea I, Romojaro F, Parras P, Jiménez AM, Martínez-Tomé M. Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric Food Chem 2004;52:1872-81.
25. Yen GC, Chong Y, Su S. Antioxidant activity and active compounds of rice koji fermented with Aspergillus candidus. Food Chem Toxicol 2003;83:49-52.
26. Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J. The antioxidant effects of isoflavon glibridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 1998;137:49-61.
27. Liu N, Huo G, Zhang L, Zhang X. Effect of Zingiber officinale roscoe on lipid per oxidation in hyperlipidemia rats. Wei Sheng Yan Jiu 2003;32:22-3.
28. Akhany SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of i officinale in streptozotocin-induced type 1 diabetic rats. J Pharm Pharmacol 2004;56:101-5.
29. Platel K, Srinivasan K. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung 2000;1:42-6.
30. Mary JM, John PK. Agents used in hyperlipidemia. In: Katzung BG, Basic and clinical pharmacology. 8 th ed. New York: McGraw-Hill; 2000. p. 581-95.
31. Soni KB, Rajan A, Kuttan R. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett 1992;66:115-21.
32. Kar A, Choudhary BK, Bandyopadhyay NG. Preliminary studies on the inorganic constituents of some indigenous hypoglycemic herbs on oral glucose tolerance test. J Ethnopharmacol 1991;64:179-84.
33. Castro VR. Chromium in series of Portuguese plants used in the herbal treatment of diabetes. Biol Trace Elem Res 1998;62:101-6.