Blood microRNA changes in depressed patients during antidepressant treatment

European Neuropsychopharmacology

Volumn 23, Issue 7, 2013, Pages 602-611

  Bocchio Chiavetto, Luisella ^a   Maffioletti, Elisabetta ^a,d   Bettinsoli, Paola ^a   Giovannini, Caterina ^a   Bignotti, Stefano ^a   Tardito, Daniela ^b   Corrada, Dario ^c   Milanesi, Luciano ^c   Gennarelli, Massimo ^a,d  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Antidepressant; Blood; Escitalopram; Major depression; MicroRNA; MiRNA

Indexed keywords

ESCITALOPRAM; HYPERICUM PERFORATUM EXTRACT; MICRORNA; MICRORNA 103; MICRORNA 128; MICRORNA 132; MICRORNA 183; MICRORNA 192; MICRORNA 22; MICRORNA 335; MICRORNA 34C 5P; MICRORNA 494; MICRORNA 500A; MICRORNA 502 3P; MICRORNA 770 5P; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BRAIN FUNCTION; CLINICAL ARTICLE; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HAMILTON SCALE; HUMAN; LONG TERM POTENTIATION; MAJOR DEPRESSION; MALE; MENTAL PATIENT; NERVE CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT DURATION; UPREGULATION;

ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; DATABASES, GENETIC; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICRORNAS; MIDDLE AGED; SIGNAL TRANSDUCTION;

EID: 84878881944     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.06.013     Document Type: Article

References (50)

1. aan het Rot M., Mathew S.J., Charney D.S. Neurobiological mechanisms in major depressive disorder. CMAJ 2009, 180:305-313.
2. Anacker C., Zunszain P.A., Carvalho L.A., Pariante C.M. The glucocorticoid receptor: pivot of depression and of antidepressant treatment?. Psychoneuroendocrinology 2011, 36:415-425.
3. Baudry A., Mouillet-Richard S., Schneider B., Launay J.M., Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science 2010, 329:1537-1541.
4. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 1995, 57:289-300.
5. Beveridge N.J., Gardiner E., Carroll A.P., Tooney P.A., Cairns M.J. Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol. Psychiatry 2010, 15:1176-1189.
6. Caputo V., Sinibaldi L., Fiorentino A., Parisi C., Catalanotto C., Pasini A., Cogoni C., Pizzuti A. Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding. PLoS One 2011, 6:e28656.
7. Castrén E., Rantamäki T. Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment. CNS Drugs 2010, 24:1-7.
8. Catania A., Lonati C., Sordi A., Gatti S. Detrimental consequences of brain injury on peripheral cells. Brain Behav. Immun. 2009, 23:877-884.
9. Cattaneo A., Bocchio-Chiavetto L., Zanardini R., Milanesi E., Placentino A., Gennarelli M. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. Int. J. Neuropsychopharmacol. 2010, 13:103-108.
10. Cattaneo A., Sesta A., Calabrese F., Nielsen G., Riva M.A., Gennarelli M. The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. Neuropsychopharmacology 2010, 35:1423-1428.
11. Chen H., Wang N., Burmeister M., McInnis M.G. MicroRNA expression changes in lymphoblastoid cell lines in response to lithium treatment. Int. J. Neuropsychopharmacol. 2009, 12:975-981.
12. Corrada D., Viti F., Merelli I., Battaglia C., Milanesi L. myMIR: a genome-wide microRNA targets identification and annotation tool. Brief. Bioinform. 2011, 12:588-600.
13. Dvinge H., Bertone P. HTqPCR: high-throughput analysis and visualization of quantitative real-time PCR data in R. Bioinformatics 2009, 25:3325-3326.
14. Dwivedi Y. Evidence demonstrating role of microRNAs in the etiopathology of major depression. J. Chem. Neuroanat. 2011, 42:142-156.
15. Fisar Z., Raboch J. Depression, antidepressants, and peripheral blood components. Neuroendocrinol. Lett. 2008, 29:17-28.
16. Forero D.A., van der Ven K., Callaerts P., Del-Favero J. miRNA genes and the brain: implications for psychiatric disorders. Hum. Mutat. 2010, 31:1195-1204.
17. Gardiner E., Beveridge N.J., Wu J.Q., Carr V., Scott R.J., Tooney P.A., Cairns M.J. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol. Psychiatry 2011, (Epub ahead of print). 10.1038/mp.2011.78.
18. Gormanns P., Mueller N.S., Ditzen C., Wolf S., Holsboer F., Turck C.W. Phenome-transcriptome correlation unravels anxiety and depression related pathways. J. Psychiatr. Res. 2011, 45:973-979.
19. Huntzinger E., Izaurralde E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet. 2011, 12:99-110.
20. Iga J., Ueno S., Ohmori T. Molecular assessment of depression from mRNAs in the peripheral leukocytes. Ann. Med. 2008, 40:336-342.
21. Janssen D.G., Caniato R.N., Verster J.C., Baune B.T. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum. Psychopharmacol. 2010, 25:201-215.
22. Kanehisa M., Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000, 28:27-30.
23. Kawashima H., Numakawa T., Kumamaru E., Adachi N., Mizuno H., Ninomiya M., Kunugi H., Hashido K. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Neuroscience 2010, 165:1301-1311.
24. Kim A.H., Reimers M., Maher B., Williamson V., McMichael O., McClay J.L., van den Oord E.J., Riley B.P., Kendler K.S., Vladimirov V.I. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr. Res. 2010, 124:183-191.
25. Lai C.Y., Yu S.L., Hsieh M.H., Chen C.H., Chen H.Y., Wen C.C., Huang Y.H., Hsiao P.C., Hsiao C.K., Liu C.M., Yang P.C., Hwu H.G., Chen W.J. MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. PLoS One 2011, 6:e21635.
26. Laterza O.F., Lim L., Garrett-Engele P.W., Vlasakova K., Muniappa N., Tanaka W.K., Johnson J.M., Sina J.F., Fare T.L., Sistare F.D., Glaab W.E. Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin. Chem. 2009, 55:1977-1983.
27. Liang Y., Ridzon D., Wong L., Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 2007, 8:166.
28. Marazziti D., Consoli G., Masala I., Catena Dell'Osso M., Baroni S. Latest advancements on serotonin and dopamine transporters in lymphocytes. Mini Rev. Med. Chem. 2010, 10:32-40.
29. Meerson A., Cacheaux L., Goosens K.A., Sapolsky R.M., Soreq H., Kaufer D. Changes in brain MicroRNAs contribute to cholinergic stress reactions. J. Mol. Neurosci. 2010, 40:47-55.
30. Mellios N., Huang H.S., Grigorenko A., Rogaev E., Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum. Mol. Genet. 2008, 17:3030-3042.
31. Mellios N., Sugihara H., Castro J., Banerjee A., Le C., Kumar A., Crawford B., Strathmann J., Tropea D., Levine S.S., Edbauer D., Sur M. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity. Nat. Neurosci. 2011, 14:1240-1242.
32. Muiños-Gimeno M., Guidi M., Kagerbauer B., Martín-Santos R., Navinés R., Alonso P., Menchón J.M., Gratacòs M., Estivill X., Espinosa-Parrilla Y. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum. Mutat. 2009, 30:1062-1071.
33. Müller N., Schwarz M.J. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol. Psychiatry 2007, 12:988-1000.
34. Pariante C.M. Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. Ann. N. Y. Acad. Sci. 2009, 1179:144-152.
35. Perkins D.O., Jeffries C.D., Jarskog L.F., Thomson J.M., Woods K., Newman M.A., Parker J.S., Jin J., Hammond S.M. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol. 2007, 8:R27.
36. Pittenger C., Duman R.S. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008, 33:88-109.
37. Popoli M., Yan Z., McEwen B.S., Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat. Rev. Neurosci. 2011, 30:22-37.
38. Rinaldi A., Vincenti S., De Vito F., Bozzoni I., Oliverio A., Presutti C., Fragapane P., Mele A. Stress induces region specific alterations in microRNAs expression in mice. Behav. Brain Res. 2010, 208:265-269.
39. Sanacora G., Treccani G., Popoli M. Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 2012, 62:63-77.
40. Sarachana T., Zhou R., Chen G., Manji H.K., Hu V.W. Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Med. 2010, 2:23.
41. Skog J., Würdinger T., van Rijn S., Meijer D.H., Gainche L., Sena-Esteves M., Curry W.T., Carter B.S., Krichevsky A.M., Breakefield X.O. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 2008, 10:1470-1476.
42. Smalheiser N.R., Lugli G., Rizavi H.S., Torvik V.I., Turecki G., Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One 2012, 7:e33201.
43. Soreq H., Wolf Y. NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol. Med. 2011, 17:548-555.
44. Tardito D., Perez J., Tiraboschi E., Musazzi L., Racagni G., Popoli M. Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol. Rev. 2006, 58:115-134.
45. Tavazoie S., Hughes J.D., Campbell M.J., Cho R.J., Church G.M. Systematic determination of genetic network architecture. Nat. Genet. 1999, 22:281-285.
46. Wayman G.A., Davare M., Ando H., Fortin D., Varlamova O., Cheng H.Y., Marks D., Obrietan K., Soderling T.R., Goodman R.H., Impey S. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc. Natl. Acad. Sci. U. S. A 2008, 105:9093-9098.
47. Zeng L., Liu J., Wang Y., Wang L., Weng S., Tang Y., Zheng C., Cheng Q., Chen S., Yang G.Y. MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia. Front. Biosci. 2011, 3:1265-1272.
48. Zeng Y. Regulation of the mammalian nervous system by microRNAs. Mol. Pharmacol. 2009, 75:259-264.
49. Zhou R., Yuan P., Wang Y., Hunsberger J.G., Elkahloun A., Wei Y., Damschroder-Williams P., Du J., Chen G., Manji H.K. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology 2009, 34:1395-1405.
50. Zovoilis A., Agbemenyah H.Y., Agis-Balboa R.C., Stilling R.M., Edbauer D., Rao P., Farinelli L., Delalle I., Schmitt A., Falkai P., Bahari-Javan S., Burkhardt S., Sananbenesi F., Fischer A. microRNA-34c is a novel target to treat dementias. EMBO J. 2011, 30:4299-4308.