Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity

Development

Volumn 130, Issue 5, 2003, Pages 955-968

  Take uchi, Masaya ^a   Clarke, Jonathan D W ^a   Wilson, Stephen W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Coloboma; Eye; Fgf; Hedgehog; Optic stalk; Vax; Zebrafish

Indexed keywords

FIBROBLAST GROWTH FACTOR; HOMEODOMAIN PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; ZEBRAFISH PROTEIN;

ANIMAL TISSUE; CELL FUSION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; FOREBRAIN; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE LOCUS; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTIC NERVE; PIGMENT EPITHELIUM; PREOPTIC AREA; PRIORITY JOURNAL; RETINA; RETINA NERVE CELL; REVIEW; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALS; BODY PATTERNING; COLOBOMA; EYE PROTEINS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION; NEUROPEPTIDES; OPTIC NERVE; PHYLOGENY; RECEPTORS, CELL SURFACE; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; RETINA; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; XENOPUS PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; ERINACEIDAE; VERTEBRATA;

EID: 0037348570     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00305     Document Type: Review

References (65)

1. Barbieri, A. M., Broccoli, V., Bovolenta, P., Alfano, G., Marchitiello, A., Mocchetti, C., Crippa, L., Bulfone, A., Marigo, V., Ballabio, A. et al. (2002). Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development 129, 805-813.
2. Barbieri, A. M., Lupo, G., Bulfone, A., Andreazzoli, M., Mariani, M., Fougerousse, F., Consalez, G. G., Borsani, G., Beckmann, J. S., Barsacchi, G. et al. (1999). A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis. Proc. Natl. Acad. Sci. USA 96, 10729-10734.
3. Barth, K. A. and Wilson, S. W. (1995). Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development 121, 1755-1768.
4. Bertuzzi, S., Hindges, R., Mui, S. H., O'Leary, D. D. and Lemke, G. (1999). The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 13, 3092-3105.
5. Bisgrove, B. W., Essner, J. J. and Yost, H. J. (1999). Regulation of midline development by antagonism of lefty and nodal signaling. Development 126, 3253-3262.
6. Chen, W., Burgess, S. and Hopkins, N. (2001). Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development 128, 2385-2396.
7. Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.
8. Connor, R. J., Menzel, P. and Pasquale, E. B. (1998). Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system. Dev. Biol. 193, 21-35.
9. Ekker, S. C., Ungar, A. R., Greenstein, P., von Kessler, D. P., Porter, J. A., Moon, R. T. and Beachy, P. A. (1995). Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr. Biol. 5, 944-955.
10. Eph Nomenclature Committee (1997). Unified nomenclature for Eph family receptors and their ligands, the Ephrins. Cell 90, 403-404.
11. Erter, C. E., Wilm, T. P., Basler, N., Wright, C. V. and Solnica-Krezel, L. (2001). Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development 128, 3571-3583.
12. Favor, J., Sandulache, R., Neuhauser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Sporle, R. et al. (1996). The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. USA 93, 13870-13875.
13. Feldman, B., Gates, M. A., Egan, E. S., Dougan, S. T., Rennebeck, G., Sirotkin, H. I., Schier, A. F. and Talbot, W. S. (1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395, 181-185.
14. Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-I. and Postlethwait, J. (1999). Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151, 1531-1545.
15. Gritsman, K., Zhang, J., Cheng, S., Heckscher, E., Talbot, W. S. and Schier, A. F. (1999). The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell 97, 121-132.
16. Gritsman, K., Talbot, W. S. and Schier, A. (2000). Nodal signaling patterns the organizer. Development 127, 921-932.
17. Hallonet, M., Hollemann, T., Pieler, T. and Gruss, P. (1999). Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev. 13, 3106-3114.
18. Hallonet, M., Hollemann, T., Wehr, R., Jenkins, N. A., Copeland, N. G., Pieler, T. and Gross, P. (1998). Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development 125, 2599-2610.
19. Holash, J. A. and Pasquale, E. B. (1995). Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Dev. Biol. 172, 683-693.
20. Holmberg, J. and Frisen, J. (2002). Ephrins are not only unattractive. Trends Neurosci. 25, 239-243.
21. Houart, C., Westerfield, M. and Wilson, S. W. (1998). A small population of anterior cells patterns the forebrain during zebrafish gastrulation. Nature 391, 788-792.
22. Houart, C., Caneparo, L., Heisenberg, C.-P., Barth, K. A., Take-uchi, M. and Wilson, S. W. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signalling. Neuron 35, 255-265.
23. Ingham, P. W. and McMahon, A. P. (2001). Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087.
24. Karlstrom, R. O., Talbot, W. S. and Schier, A. F. (1999). Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev. 13, 388-393.
25. Karlstrom, R. O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A. D., Grunewald, B., Haffter, P., Hoffmann, H., Meyer, S. U. et al. (1996). Zebrafish mutations affecting retinorectal axon pathfinding. Development 123, 427-438.
26. Litinghung, Y. and Chiang, C. (2000). Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3, 979-985.
27. Lynch, M. and Force, A. (2000). The probability of duplicate gene preservation by subfunctionalization. Genetics 154, 459-473.
28. Macdonald, R., Xu, Q., Barth, K. A., Mikkola, I., Holder, N., Fjose, A., Krauss, S. and Wilson, S. W. (1994). Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron 13, 1039-1053.
29. Macdonald, R., Barth, K. A., Xu, Q., Holder, N., Mikkola, I. and Wilson, S. W. (1995). Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 121, 3267-3278.
30. Macdonald, R., Scholes, J., Strahle, U., Brennan, C., Holder, N., Brand, M. and Wilson, S.W. (1997). The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development 124, 2397-2408.
31. Masai, I., Stemple, D. L., Okamoto, H. and Wilson, S. W. (2000). Midline signals regulate retinal neurogenesis in zebrafish. Neuron 27, 251-263.
32. Mathieu, J., Barth, A., Rosa, F. M., Wilson, S. W. and Peyriéras, N. (2002). Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development. Development 129, 3055-3065.
33. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J. et al. (1999). Mouse Lefty2 and zebrafish Antivin are feedback inhibitors of Nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298.
34. Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B., Hubbard, S. and Schlessinger, J. (1997). Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276, 955-960.
35. Mui, S. H., Hindges, R., O'Leary, D. D. M., Lemke, G. and Bertuzzi, S. (2002). The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development 129, 797-804.
36. Muller, F., Albert, S., Blader, P., Fischer, N., Hallonet, M. and Strahle, U. (2000). Direct action of the Nodal-related signal Cyclops in induction of sonic hedgehog in the ventral midline of the CNS. Development 127, 3889-3897.
37. Nasevicius, A. and Ekker, S. C. (2000). Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220.
38. Neuhauss, S. C., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A. and Baier, H. (1999). Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J. Neurosci. 19, 8603-8615.
39. Ohsaki, K., Morimitsu, T., Ishida, Y., Kominami, R. and Takahashi, N. (1999). Expression of the Vax family homeobox genes suggests multiple roles in eye development. Genes Cells 4, 267-276.
40. Pfeffer, P. L., Gerster, T., Lun, K., Brand, M. and Busslinger, M. (1998). Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development 125, 3063-3074.
41. Rallu, M., Machold, R., Gaiano, N., Corbin, J. G., McMahon, A. P. and Fishell, G. (2002). Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 129, 4963-4974.
42. Rebagliati, M. R., Toyama, R., Haffter, P. and Dawid, I. B. (1998). cyclops encodes a nodal-related factor involved in midline signaling. Proc. Natl. Acad. Sci. USA 95, 9932-9937.
43. Reifers, F., Bohli, H., Walsh, E. C., Crossley, P. H., Stainier, D. Y. and Brand, M. (1998). Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development 125, 2381-2395.
44. Reifers, F., Adams, J., Mason, I., Schulte-Merker, S. and Brand, M. (2000). Overlapping and distinct functions provided by fgf17, a new zebrafish member of Fgf8/17/18 subgroup of Fgfs. Mech. Dev. 99, 39-49.
45. Rick, J. M., Horschke, I. and Neuhauss, S. C. (2000). Optokinetic behavior is reversed in achiasmatic mutant zebrafish larvae. Curr. Biol. 10, 595-598.
46. Rohr, K. B. and Concha, M. L. (2000). Expression of nk2.1a during early development of the thyroid gland in zebrafish. Mech. Dev. 95, 267-270.
47. Rohr, K. B., Barth, K. A., Varga, Z. M. and Wilson, S. W. (2001). The Nodal pathway acts upstream of Hedgehog signaling to specify ventral telencephalic identity. Neuron 29, 341-351.
48. Sampath, K., Rubinstein, A. L., Cheng, A. M., Liang, J. O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M. E. and Wright, C. V. (1998). Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature 395, 185-189.
49. Sanyanusin, P., McNoe, L. A., Sullivan, M. J., Weaver, R. G. and Eccles, M. R. (1995). Mutation of PAX2 in two siblings with renal-coloboma syndrome. Hum. Mol. Genet. 4, 2183-2184.
50. Schauerte, H. E., van Eeden, F. J. M., Fricke, C., Odenthal, J., Strähle, U. and Haffter, P. (1998). Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development 125, 2983-2993.
51. Schulte, D., Furukawa, T., Peters, M. A., Kozak, C. A. and Cepko, C. L. (1999). Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron 24, 541-553.
52. Schwarz, M., Cecconi, F., Bernier, G., Andrejewski, N., Kammandel, B., Wagner, M. and Gruss, P. (2000). Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development 127, 4325-4333.
53. Shanmugalingam, S., Houart, C., Picker, A., Reifers, F., Macdonald, R., Barth, A., Griffin, K., Brand, M. and Wilson, S. W. (2000). Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development 127, 2549-2561.
54. Shimamura, K. and Rubenstein, J. L. R. (1997). Inductive interactions direct early regionalization of the mouse forebrain. Development 124, 2709-2718.
55. Shinya, M., Koshida, S., Sawada, A., Kuroiwa, A. and Takeda, H. (2001). Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development 128, 4153-4164.
56. Thisse, B., Wright, C. V. and Thisse, C. (2000). Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-428.
57. Thisse, C. and Thisse, B. (1999). Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction. Development 126, 229-240.
58. Torres, M., Gomez-Pardo, E. and Gruss, P. (1996). Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391.
59. Ungar, A. R. and Moon, R. T. (1996). Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. Dev. Biol. 178, 186-191.
60. van Eeden, F. J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.-P., Jiang, Y. J., Kane, D. A. et al. (1996). Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development 123, 153-164.
61. Varga, Z. M., Amores, A., Lewis, K. E., Yan, Y.-L., Postlethwait, J. H., Eisen, J. S. and Westerfield, M. (2001). Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128, 3497-3509.
62. Varga, Z. M., Wegner, J. and Westerfield, M. (1999). Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops. Development 126, 5533-5546.
63. Westerfield, M. (1993). The Zebrafish Book. Eugene, OR: The University of Oregon Press.
64. Winkler, S., Loosli, F., Henrich, T., Wakamatsu, Y. and Wittbrodt, J. (2000). The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye. Development 127, 1911-1919.
65. Zhang, J., Talbot, W. S. and Schier, A. F. (1998). Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 92, 241-251.