Multivalent histone engagement by the linked tandem tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

Genes and Development

Volumn 27, Issue 11, 2013, Pages 1288-1298

  Rothbart, Scott B ^a,b   Dickson, Bradley M ^b   Ong, Michelle S ^c,d,e,f   Krajewski, Krzysztof ^a   Houliston, Scott ^c,d,e,f   Kireev, Dmitri B ^b   Arrowsmith, Cheryl H ^c,d,e,f   Strahl, Brian D ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e PRINCESS MARGARET HOSPITAL   (Canada)

^f Ampbell Family Institute for Cancer Research   (United States)

Author keywords

DNA methylation; DNMT1; Epigenetic inheritance; Histone code; Multivalency; UHRF1

Indexed keywords

DNA; HISTONE; HISTONE H3; MEMBRANE PROTEIN; TANDEM TUDOR PROTEIN; UBIQUITIN; UBIQUITIN LIKE PHD AND RING FINGER DOMAIN CONTAINING PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; EPIGENETIC INHERITANCE; EPIGENETICS; HETEROCHROMATIN; HYPOTHESIS; IN VITRO STUDY; INHERITANCE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS;

EID: 84878838423     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.220467.113     Document Type: Article

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