메뉴 건너뛰기




Volumn 41, Issue 11, 2013, Pages 5827-5836

5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ATR PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DNA METHYLTRANSFERASE 1; FANCONI ANEMIA GROUP G PROTEIN; HISTONE H2AX; RAD51 PROTEIN;

EID: 84878834721     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt270     Document Type: Article
Times cited : (55)

References (44)
  • 1
    • 0035962631 scopus 로고    scopus 로고
    • DNA methylation, methyltransferases, and cancer
    • Robertson, K.D. (2001) DNA methylation, methyltransferases, and cancer. Oncogene, 20, 3139-3155.
    • (2001) Oncogene , vol.20 , pp. 3139-3155
    • Robertson, K.D.1
  • 2
    • 0037068379 scopus 로고    scopus 로고
    • 5-azacytidine and 5-aza-20-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman, J.K. (2002) 5-azacytidine and 5-aza-20-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene, 21, 5483-5495.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 3
    • 37849026412 scopus 로고    scopus 로고
    • DNA methylation inhibitor 5-aza-20-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
    • Palii, S.S., Van Emburgh, B.O., Sankpal, U.T., Brown, K.D. and Robertson, K.D. (2008) DNA methylation inhibitor 5-aza-20-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol. Cell. Biol., 28, 752-771.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 752-771
    • Palii, S.S.1    Van Emburgh, B.O.2    Sankpal, U.T.3    Brown, K.D.4    Robertson, K.D.5
  • 4
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-20-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann, R., Li, E. and Jaenisch, R. (1994) Toxicity of 5-aza-20-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl Acad. Sci. USA, 91, 11797-11801.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 7
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman, J.G. and Baylin, S.B. (2003) Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med., 349, 2042-2054.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 8
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A. and Baylin, S.B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 11
    • 0019944339 scopus 로고
    • Multiple squamous-cell carcinomas in fanconi's anemia
    • Kennedy, A.W. and Hart, W.R. (1982) Multiple squamous-cell carcinomas in fanconi's anemia. Cancer, 50, 811-814.
    • (1982) Cancer , vol.50 , pp. 811-814
    • Kennedy, A.W.1    Hart, W.R.2
  • 12
    • 0037439356 scopus 로고    scopus 로고
    • Cancer in fanconi anemia 1927-2001
    • Alter, B.P. (2003) Cancer in fanconi anemia, 1927-2001. Cancer, 97, 425-440.
    • (2003) Cancer , vol.97 , pp. 425-440
    • Alter, B.P.1
  • 13
    • 27644455749 scopus 로고    scopus 로고
    • Molecular pathogenesis of fanconi anemia
    • Collins, N. and Kupfer, G.M. (2005) Molecular pathogenesis of fanconi anemia. Int. J. Hematol., 82, 176-183.
    • (2005) Int. J. Hematol. , vol.82 , pp. 176-183
    • Collins, N.1    Kupfer, G.M.2
  • 14
    • 0037214260 scopus 로고    scopus 로고
    • Genetic basis of fanconi anemia
    • Bagby, G.C. Jr. (2003) Genetic basis of fanconi anemia. Curr. Opin. Hematol., 10, 68-76.
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 68-76
    • Bagby Jr., G.C.1
  • 15
    • 0035379611 scopus 로고    scopus 로고
    • The emerging genetic and molecular basis of Fanconi anaemia
    • Joenje, H. and Patel, K.J. (2001) The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet., 2, 446-457.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 446-457
    • Joenje, H.1    Patel, K.J.2
  • 16
    • 0042161939 scopus 로고    scopus 로고
    • The fanconi road to cancer
    • D'Andrea, A.D. (2003) The fanconi road to cancer. Genes Dev., 17, 1933-1936.
    • (2003) Genes Dev. , vol.17 , pp. 1933-1936
    • D'Andrea, A.D.1
  • 17
    • 30144439816 scopus 로고    scopus 로고
    • Disruption of the fanconi anemia/BRCA pathway in sporadic cancer
    • Lyakhovich, A. and Surralles, J. (2006) Disruption of the fanconi anemia/BRCA pathway in sporadic cancer. Cancer Lett., 232, 99-106.
    • (2006) Cancer Lett. , vol.232 , pp. 99-106
    • Lyakhovich, A.1    Surralles, J.2
  • 19
    • 0023518666 scopus 로고
    • Effect of exogenous thymidine on sister-chromatid exchange frequency in Chinese hamster ovary cells with bromodeoxyuridine-and chlorodeoxyuridine- substituted chromosomes
    • Corte?s, F., Morgan, W.F. and Wolff, S. (1987) Effect of exogenous thymidine on sister-chromatid exchange frequency in Chinese hamster ovary cells with bromodeoxyuridine-and chlorodeoxyuridine-substituted chromosomes. Mutat. Res., 192, 277-282.
    • (1987) Mutat. Res. , vol.192 , pp. 277-282
    • Cortes, F.1    Morgan, W.F.2    Wolff, S.3
  • 20
    • 34250767283 scopus 로고    scopus 로고
    • 5-azacytidine, a DNA methyltransferase inhibitor, induces ATRmediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells
    • Kiziltepe, T., Hideshima, T., Catley, L., Raje, N., Yasui, H., Shiraishi, N., Okawa, Y., Ikeda, H., Vallet, S., Pozzi, S. et al. (2007) 5-azacytidine, a DNA methyltransferase inhibitor, induces ATRmediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells. Mol. Cancer Ther., 6, 1718-1727.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1718-1727
    • Kiziltepe, T.1    Hideshima, T.2    Catley, L.3    Raje, N.4    Yasui, H.5    Shiraishi, N.6    Okawa, Y.7    Ikeda, H.8    Vallet, S.9    Pozzi, S.10
  • 21
    • 80052515789 scopus 로고    scopus 로고
    • UV stalled replication forks restart by re-priming in human fibroblasts
    • Elvers, I., Johansson, F., Groth, P., Erixon, K. and Helleday, T. (2011) UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Res., 39, 7049-7057.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 7049-7057
    • Elvers, I.1    Johansson, F.2    Groth, P.3    Erixon, K.4    Helleday, T.5
  • 22
    • 76849109722 scopus 로고    scopus 로고
    • Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
    • Petermann, E., Orta, M.L., Issaeva, N., Schultz, N. and Helleday, T. (2010) Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol. Cell, 37, 492-502.
    • (2010) Mol. Cell , vol.37 , pp. 492-502
    • Petermann, E.1    Orta, M.L.2    Issaeva, N.3    Schultz, N.4    Helleday, T.5
  • 23
    • 84864933506 scopus 로고    scopus 로고
    • Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
    • Groth, P., Orta, M.L., Elvers, I., Majumder, M.M., Lagerqvist, A. and Helleday, T. (2012) Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation. Nucleic Acids Res., 40, 6585-6594.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6585-6594
    • Groth, P.1    Orta, M.L.2    Elvers, I.3    Majumder, M.M.4    Lagerqvist, A.5    Helleday, T.6
  • 24
    • 37149000618 scopus 로고    scopus 로고
    • Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase i inhibitor camptothecin
    • Orta, M.L., Mateos, S., Cantero, G., Wolff, L.J. and Cortes, F. (2008) Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin. Mutat. Res., 637, 40-48.
    • (2008) Mutat. Res. , vol.637 , pp. 40-48
    • Orta, M.L.1    Mateos, S.2    Cantero, G.3    Wolff, L.J.4    Cortes, F.5
  • 25
    • 0344845194 scopus 로고    scopus 로고
    • Pathways for mitotic homologous recombination in mammalian cells
    • Helleday, T. (2003) Pathways for mitotic homologous recombination in mammalian cells. Mutat. Res., 532, 103-115.
    • (2003) Mutat. Res. , vol.532 , pp. 103-115
    • Helleday, T.1
  • 26
    • 0035853295 scopus 로고    scopus 로고
    • DNA doublestrand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
    • Arnaudeau, C., Lundin, C. and Helleday, T. (2001) DNA doublestrand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J. Mol. Biol., 307, 1235-1245.
    • (2001) J. Mol. Biol. , vol.307 , pp. 1235-1245
    • Arnaudeau, C.1    Lundin, C.2    Helleday, T.3
  • 27
    • 79959635260 scopus 로고    scopus 로고
    • DNA interstrand crosslink repair and cancer
    • Deans, A.J. and West, S.C. (2011) DNA interstrand crosslink repair and cancer. Nat. Rev. Cancer., 11, 467-480.
    • (2011) Nat. Rev. Cancer. , vol.11 , pp. 467-480
    • Deans, A.J.1    West, S.C.2
  • 28
    • 34547628200 scopus 로고    scopus 로고
    • Proteasome function is required for DNA damage response and fanconi anemia pathway activation
    • Jacquemont, C. and Taniguchi, T. (2007) Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res., 67, 7395-7405.
    • (2007) Cancer Res. , vol.67 , pp. 7395-7405
    • Jacquemont, C.1    Taniguchi, T.2
  • 30
    • 0036316015 scopus 로고    scopus 로고
    • Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
    • Lundin, C., Erixon, K., Arnaudeau, C., Schultz, N., Jenssen, D., Meuth, M. and Helleday, T. (2002) Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol. Cell. Biol., 22, 5869-5878.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5869-5878
    • Lundin, C.1    Erixon, K.2    Arnaudeau, C.3    Schultz, N.4    Jenssen, D.5    Meuth, M.6    Helleday, T.7
  • 31
    • 0037414420 scopus 로고    scopus 로고
    • RAD51 is involved in repair of damage associated with DNA replication in mammalian cells
    • Lundin, C., Schultz, N., Arnaudeau, C., Mohindra, A., Hansen, L.T. and Helleday, T. (2003) RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J. Mol. Biol., 328, 521-535.
    • (2003) J. Mol. Biol. , vol.328 , pp. 521-535
    • Lundin, C.1    Schultz, N.2    Arnaudeau, C.3    Mohindra, A.4    Hansen, L.T.5    Helleday, T.6
  • 33
    • 0034124053 scopus 로고    scopus 로고
    • Conversion of topoisomerase i cleavage complexes on the leading strand of ribosomal DNA into 50-phosphorylated DNA double-strand breaks by replication runoff
    • Strumberg, D., Pilon, A.A., Smith, M., Hickey, R., Malkas, L. and Pommier, Y. (2000) Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 50-phosphorylated DNA double-strand breaks by replication runoff. Mol. Cell. Biol., 20, 3977-3987.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3977-3987
    • Strumberg, D.1    Pilon, A.A.2    Smith, M.3    Hickey, R.4    Malkas, L.5    Pommier, Y.6
  • 34
    • 77957123627 scopus 로고    scopus 로고
    • Pathways of mammalian replication fork restart
    • Petermann, E. and Helleday, T. (2010) Pathways of mammalian replication fork restart. Nat. Rev. Mol. Cell Biol., 11, 683-687.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 683-687
    • Petermann, E.1    Helleday, T.2
  • 36
    • 36248966246 scopus 로고    scopus 로고
    • RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    • Mailand, N., Bekker-Jensen, S., Faustrup, H., Melander, F., Bartek, J., Lukas, C. and Lukas, J. (2007) RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell, 131, 887-900.
    • (2007) Cell , vol.131 , pp. 887-900
    • Mailand, N.1    Bekker-Jensen, S.2    Faustrup, H.3    Melander, F.4    Bartek, J.5    Lukas, C.6    Lukas, J.7
  • 38
    • 22144466584 scopus 로고    scopus 로고
    • The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells
    • Chen, Q., Van der Sluis, P.C., Boulware, D., Hazlehurst, L.A. and Dalton, W.S. (2005) The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells. Blood, 106, 698-705.
    • (2005) Blood , vol.106 , pp. 698-705
    • Chen, Q.1    Van Der Sluis, P.C.2    Boulware, D.3    Hazlehurst, L.A.4    Dalton, W.S.5
  • 40
    • 77953636534 scopus 로고    scopus 로고
    • Homologous recombination in cancer development, treatment and development of drug resistance
    • Helleday, T. (2010) Homologous recombination in cancer development, treatment and development of drug resistance. Carcinogenesis, 31, 955-960.
    • (2010) Carcinogenesis , vol.31 , pp. 955-960
    • Helleday, T.1
  • 42
    • 84864629020 scopus 로고    scopus 로고
    • Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia
    • Gustafsson, B., Moell, J., Leblanc, K., Barbany, G., So? derháll, S. and Winiarski, J. (2012) Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia. Pediatr. Transplant., 16, 241-245.
    • (2012) Pediatr. Transplant. , vol.16 , pp. 241-245
    • Gustafsson, B.1    Moell, J.2    Leblanc, K.3    Barbany, G.4    Soderháll, S.5    Winiarski, J.6
  • 44
    • 79955096891 scopus 로고    scopus 로고
    • Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage
    • Castillo, P., Bogliolo, M. and Surralles, J. (2011) Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage. DNA Repair, 10, 518-525.
    • (2011) DNA Repair , vol.10 , pp. 518-525
    • Castillo, P.1    Bogliolo, M.2    Surralles, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.