Activation of renal haeme oxygenase-1 alleviates gentamicin-induced acute nephrotoxicity in rats

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 7, 2013, Pages 995-1004

  Taye, Ashraf ^a   Ibrahim, Badr Mostafa ^a,b  

^a Minia University   (Egypt)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

gentamicin; haeme oxygenase; haemin; nephrotoxicity

Indexed keywords

CASPASE 3; CATALASE; CREATININE; GENTAMICIN; GLUTATHIONE; HEME OXYGENASE 1; HEMIN; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOWN REGULATION; ENZYME ACTIVATION; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; RENAL PROTECTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIOXIDANTS; CASPASE 3; CREATININE; GENTAMICINS; HEME OXYGENASE-1; HEMIN; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; NF-KAPPA B; OXIDATIVE STRESS; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878797538     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12067     Document Type: Article

References (52)

1. Weinberg JM, Humes HD,. Increases of cell ATP produced by exogenous adenine nucleotides in isolated rabbit kidney tubules. Am J Physiol 1986; 250: F720-F733.
2. Yanagida C, et al. Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem Biol Interact 2004; 148: 139-147.
3. Ali BH,. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem Toxicol 2003; 41: 1447-1452.
4. Nath KA,. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992; 20: 1-17.
5. Scapagnini G, et al. Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Res 2002; 954: 51-59.
6. Hangaishi M, et al. Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo. Biochem Biophys Res Commun 2000; 279: 582-588.
7. Le WD, et al. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 1999; 56: 652-658.
8. Morse D, Choi AM,. Heme oxygenase-1. The 'emerging molecule' has arrived. Am J Respir Cell Mol Biol 2002; 27: 8-16.
9. Ohta K, et al. Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency. Am J Kidney Dis 2000; 35: 863-870.
10. Maines MD,. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517-554.
11. Kirkby KA, Adin CA,. Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Renal Physiol 2006; 290: F563-F571.
12. Kim JH, et al. Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway. J Am Soc Nephrol 2006; 17: 1373-1381.
13. Desbuards N, et al. Heme oxygenase-1 inducer hemin attenuates the progression of remnant kidney model. Nephron Exp Nephrol 2009; 113: e35-e44.
14. Goodman AI, et al. Heme oxygenase-1 protects against radiocontrast- induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int 2007; 72: 945-953.
15. Wang R, et al. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension 2006; 48: 685-692.
16. Anderson KE, Collins S,. Open-label study of hemin for acute porphyria: clinical practice implications. Am J Med 2006; 119: 801 e819-e824.
17. Deguchi K, et al. Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress. Brain Res 2008; 1188: 1-8.
18. Cheng YW, et al. Myrrh mediates haem oxygenase-1 expression to suppress the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. J Pharm Pharmacol 2011; 63: 1211-1218.
19. Bellner L, et al. Heme oxygenase-2 deletion causes endothelial cell activation marked by oxidative stress, inflammation, and angiogenesis. J Pharmacol Exp Ther 2009; 331: 925-932.
20. Aizawa T, et al. Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats: possible role in renoprotection. Hypertension 2000; 35: 800-806.
21. Silan C, et al. Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Biol Pharm Bull 2007; 30: 79-83.
22. Fawcett JK, Scott JE,. A rapid and precise method for the determination of urea. J Clin Pathol 1960; 13: 156-159.
23. Vera T, et al. HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice. Am J Physiol Regul Integr Comp Physiol 2007; 292: R1472-R1478.
24. Ellman GL,. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82: 70-77.
25. Uchiyama M, Mihara M,. Determination of malonaldehyde precursor in tissues by thiobarbituris acid test. Anal of Biochemistry 1978; 86: 271-278.
26. Sun M, Zigman S,. An improved spectrophotometric assay for superoxide dismutase based on epinephrine autoxidation. Anal Biochem 1978; 90: 81-89.
27. Aebi H,. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
28. Taye A, et al. Effect of apocynin on NADPH oxidase-mediated oxidative stress-LOX-1-eNOS pathway in human endothelial cells exposed to high glucose. Eur J Pharmacol 2010; 627: 42-48.
29. Ali BH, et al. Gentamicin nephrotoxicity in rat: some biochemical correlates. Pharmacol Toxicol 1992; 70: 419-423.
30. Kadkhodaee M, et al. Effects of co-supplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat. Exp Physiol 2005; 90: 571-576.
31. Esser E, Loschen G,. Leukocytic O2- and cardiac dysfunctions in isolated perfused rat hearts. Arch Toxicol 1991; 65: 361-365.
32. Bulger EM, et al. Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress. Surgery 2003; 134: 146-152.
33. Wen T, et al. Upregulation of heme oxygenase-1 with hemin prevents d-galactosamine and lipopolysaccharide-induced acute hepatic injury in rats. Toxicology 2007; 237: 184-193.
34. Grangeiro NM, et al. Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor. Pharmacol Rep 2011; 63: 112-119.
35. Abraham NG, Kappas A,. Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008; 60: 79-127.
36. Kushida T, et al. A significant role for the heme oxygenase-1 gene in endothelial cell cycle progression. Biochem Biophys Res Commun 2002; 291: 68-75.
37. Taille C, et al. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 2004; 279: 28681-28688.
38. Stocker R, et al. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-1046.
39. Johnson FK, et al. Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats. Hypertension 2003; 41: 149-155.
40. Otterbein LE, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-428.
41. Zager RA, et al. Gentamicin suppresses endotoxin-driven TNF-alpha production in human and mouse proximal tubule cells. Am J Physiol Renal Physiol 2007; 293: F1373-F1380.
42. Petry KG, et al. Magnetic resonance imaging of human brain macrophage infiltration. Neurotherapeutics 2007; 4: 434-442.
43. Tzima S, et al. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 2009; 206: 1167-1179.
44. Fouad AA, et al. Therapeutic potential of hemin in acetaminophen nephrotoxicity in rats. Environ Toxicol Pharmacol 2009; 27: 277-282.
45. Zhang B, et al. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem 2003; 278: 28443-28454.
46. Sasaki T, et al. Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction. Med Chem 2006; 2: 271-274.
47. Hernandez-Presa M, et al. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation 1997; 95: 1532-1541.
48. Kopp EB, Ghosh S,. NF-kappa B and rel proteins in innate immunity. Adv Immunol 1995; 58: 1-27.
49. Faubion WA, Gores GJ,. Death receptors in liver biology and pathobiology. Hepatology 1999; 29: 1-4.
50. Kim SH, Lee SM,. Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. J Pineal Res 2008; 44: 165-171.
51. Ollinger R, et al. Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal 2007; 9: 2175-2185.
52. Olszanecki R, et al. Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway. Am J Physiol Renal Physiol 2007; 292: F148-F157.