Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice

Redox Biology

Volumn 1, Issue 1, 2013, Pages 110-114

  Liu, Jinbo ^a,b   Li, Wei ^a,b   Chen, Rui ^b   McIntyre, Thomas M ^a,b  

^a CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Factor Oxidized; Inflammation; phospholipid Pharmacokinetics; Platelet activating

Indexed keywords

AZELAOYL PHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; AZELAOYLPHOSPHATIDYLCHOLINE;

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY THROMBOSIS; CIRCULATION; CONTROLLED STUDY; DEPOLARIZATION; FEMALE; HUMAN; IN VIVO STUDY; LIPID BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX; ANIMAL; BLOOD; C57BL MOUSE; METABOLISM; OXIDATION REDUCTION REACTION; SEXUAL DEVELOPMENT; CELL SURFACE; HUMAN CELL; KIDNEY; LIPID OXIDATION; LIVER; MITOCHONDRION; THROMBOCYTE;

ANIMALIA; MUS; RATTUS;

AGING; ANIMALS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHOLIPIDS; SEX CHARACTERISTICS;

EID: 84878782509     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2012.11.011     Document Type: Article

References (27)

1. J. Adachi, S. Matsushita, N. Yoshioka, R. Funae, T. Fujita, S. Higuchi, et al., Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patients, Journal of Lipid Research 45 (5) (2004) 967-971.
2. T.M. McIntyre, Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: formation, targets, and inactivation, Biochimica et Biophysica Acta 1818 (10) (2012) 2456-2464.
3. D.M. Stafforini, Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2), Cardiovascular Drugs and Therapy 23 (1) (2009) 73-83.
4. T.M. McIntyre, S.M. Prescott, D.M. Stafforini, The emerging roles of PAF acetylhydrolase, Journal of Lipid Research 50 (Suppl.) (2009) S255-S259.
5. H. Arai, H. Koizumi, J. Aoki, K. Inoue, Platelet-activating factor acetylhydrolase (PAF-AH), Journal of Biochemistry (Tokyo) 131 (5) (2002) 635-640.
6. C.H. MacPhee, K.E. Moores, H.F. Boyd, D. Dhanak, R.J. Ife, C.A. Leach, et al., Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhy-drolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor, Biochemical Journal 338 (2) (1999) 479-487.
7. A. Zalewski, J.J. Nelson, L. Hegg, C. Macphee, Lp-PLA2: a new kid on the block, Clinical Chemistry 52 (9) (2006) 1645-1650.
8. C.H. Macphee, J. Nelson, A. Zalewski, Role of lipoprotein-associated phospho-lipase A2 in atherosclerosis and its potential as a therapeutic target, Current Opinion in Pharmacology 6 (2) (2006) 154-161.
9. P.W. Serruys, H.M. Garcia-Garcia, P. Buszman, P. Erne, S. Verheye, M. Aschermann, et al., Effects of the direct lipoprotein-associated phospho-lipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque, Circulation 118 (11) (2008) 1172-1182.
10. S.M. Prescott, T.M. McIntyre, G.A. Zimmerman, Platelet-activating Factor: a phospholipid mediator of inflammation, in: J.I. Gallin, R. Snyderman (Eds.), Inflammation: Basic Principles and Clinical Correlates, Lippincott Williams and Wilkins, Philadelphia, 1999, pp. 387-396.
11. R. Chen, E. Brady, T.M. McIntyre, Human TMEM30a promotes uptake of anti-tumor and bioactive choline phospholipids into mammalian cells, Journal of Immunology 186 (5) (2011) 3215-3225.
12. K. Chen, W. Li, J. Major, S.O. Rahaman, M. Febbraio, R.L. Silverstein, Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombo-tic state, Blood 117 (21) (2011) 5744-5750.
13. E.G. Bligh, W.J. Dyer, A rapid method of total lipid extraction and purification, Canadian Journal of Biochemistry and Physiology 37 (1959) 911-917.
14. G.K. Marathe, S.S. Davies, K.A. Harrison, A.R. Silva, R.C. Murphy, H. Castro-Faria-Neto, et al., Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines, Journal of Biological Chemistry 274 (40) (1999) 28395-28404.
15. C. Latchoumycandane, G.K. Marathe, R. Zhang, T.M. McIntyre, Oxidatively truncated phospholipids are required agents of tumor necrosis factor alpha (TNFalpha)-induced apoptosis, Journal of Biological Chemistry 287 (21) (2012) 17693-17705.
16. F. Snyder, V. Fitzgerald, M.L. Blank, Biosynthesis of platelet-activating factor and enzyme inhibitors, Advances in Experimental Medicine and Biology 416 (1996) 5-10.
17. S.M. Prescott, G.A. Zimmerman, D.M. Stafforini, T.M. McIntyre, Platelet-activating factor and related lipid mediators, Annual Review of Biochemistry 69 (2000) 419-445.
18. D.C. Tsoukatos, M. Arborati, T. Liapikos, K.L. Clay, R.C. Murphy, M.J. Chapman, et al., Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL, Arterio-sclerosis, Thrombosis, and Vascular Biology 17 (12) (1997) 3505-3512.
19. L. Yang, C. Latchoumycandane, M.R. McMullen, B.T. Pratt, R. Zhang, B.G. Papouchado, et al., Chronic alcohol exposure increases circulating bioactive oxidized phospholipids, Journal of Biological Chemistry (2010) 22211-22220.
20. R. Chen, X. Chen, R.G. Salomon, T.M. McIntyre, Platelet activation by low concentrations of intact oxidized LDL particles involves the PAF receptor, Arteriosclerosis, Thrombosis, and Vascular Biology 29 (3) (2009) 363-371.
21. R. Chen, A.E. Feldstein, T.M. McIntyre, Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL, Journal of Biological Chemistry 284 (39) (2009) 26297-26308.
22. R. Chen, L. Yang, T.M. McIntyre, Cytotoxic phospholipid oxidation products. Cell death from mitochondrial damage and the intrinsic caspase cascade, Journal of Biological Chemistry 282 (34) (2007) 24842-24850.
23. W. Li, M. Febbraio, S.P. Reddy, D.Y. Yu, M. Yamamoto, R.L. Silverstein, CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs, Journal of Clinical Investigation 120 (11) (2010) 3996-4006.
24. E.N. Frankel, Chemistry of free radical and singlet oxidation of lipids, Progress in Lipid Research 23 (1984) 197-221.
25. S.S. Davies, A.V. Pontsler, G.K. Marathe, K.A. Harrison, R.C. Murphy, J.C. Hinshaw, et al., Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists, Journal of Biological Chemistry 276 (19) (2001) 16015-16023.
26. T. Noji, T. Yamamoto, K. Saito, K. Fujimura-Kamada, S. Kondo, K. Tanaka, Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast, Biochemical and Biophysical Research Commu-nications 344 (1) (2006) 323-331.
27. U. Kato, K. Emoto, C. Fredriksson, H. Nakamura, A. Ohta, T. Kobayashi, et al., A novel membrane protein, Ros3p, is required for phospholipid translocation across theplasmamembranein Saccharomyces cerevisiae, JournalofBiological Chemistry 277(40)(2002)37855-37862.