Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies: Protective role of PAF:Acetylhydrolase in dense LDL

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 12, 1997, Pages 3505-3512

  Tsoukatos, Demokritos C ^a   Arborati, Muriel ^b   Liapikos, Theodoras ^a   Clay, Keith L ^c   Murphy, Robert C ^c   Chapman, M John ^b   Ninio, Ewa ^b  

^a UNIVERSITY OF IOANNINA   (Greece)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Density gradient ultracentrifugation; Inflammation; Lipoprotein particle subspecies

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; THROMBOCYTE ACTIVATING FACTOR;

ADULT; ARTICLE; ATHEROGENESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION;

EID: 0031458497     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.12.3505     Document Type: Article

References (20)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity N Eng J Med. 1989;320:915-924.
2. Camejo G, Hurt-Camejo E, Olsson U, Bondjers G. Proteoglycans and lipoproteins in atherosclerosis. Curr Opin Lipid. 1993;4:385-391.
3. Esterbauer H, Dieber-Rotheneder M, Waeg G, Striegl G, Jürgens G. Biochemical, structural, and functional properties of oxidized low-density lipoprotein. Chem Res Toxicol. 1990;3:77-92.
4. Brown AJ, Dean RT, Jessup W. Free and esterfied oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. J Lipid Res. 1996;37:320-335.
5. Quinn MT, Parthasarathy S, Steinberg D. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proc Natl Acad Sci USA. 1988;85:2805-2809.
6. Smiley PL, Stremler KE, Prescott SM, Zimmerman GA, McIntyre TM. Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor. J Biol Chem. 1991;266:11104-11110.
7. Patel KD, Zimmerman GA, Prescott SM, McIntyre TM. Novel leukocyte agonists are released by endothelial cells exposed to peroxide. J Biol Chem. 1992;266:11104-11110.
8. Benveniste J. Paf-acether, an ether phospholipid with biological activity. Biological Membranes: Aberrations in Membrane Structure and Function. 1988;73-85.
9. Evangelou AM. Platelet-activating factor (PAF): implications for coronary heart and vascular diseases. Prostagl Leukotr Essent Fatty acids. 1994;50:1-28.
10. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
11. Farr RS, Cox CP, Wardlow ML, Jorgensen R. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). Clin Immunol Immunopathol. 1980;15:318-330.
12. Blank ML, Lee TC, Fitzgerald V, Snyder F. A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J Biol Chem. 1981;256:175-178.
13. Stafforini DM, McIntyre TM, Carter ME, Prescott SM. Human plasma platelet-activating factor acetylhydrolase: association with lipoprotein particles and role in the degradation of platelet-activating factor. J Biol Chem. 1987;262:4215-4222.
14. Stremler KE, Stafforini DM, Prescott SM, Zimmerman GA, McIntyre T. M. An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma. J Biol Chem. 1989;264:5331-5334.
15. Karabina SAP, Liapikos TA, Grekas G, Goudevenos J, Tselepis AD. Distribution of PAF-acetylhydrolase activity in human plasma low-density lipoprotein subfractions. Biochim Biophys Acta. 1994;1213:34-38.
16. Tselepis AD, Dentan C, Karabina SAP, Chapman MJ, Ninio E. Paf-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma. Catalytic characteristics and relation to the monocyte-derived enzyme. Artcrioscler Thromb Vasc Biol. 1995;15:1764-1773.
17. Elstad MR, Stafforini DM, McIntyre TM, Prescott SM, Zimmerman G. A. Platelet-activating factor acetylhydrolase increase during macrophage differentiation: a novel mechanism that regulates accumulation of platelet-activating factor. J Biol Chem. 1989;264:8467-8470.
18. Palmantier R, Dulioust A, Maïza H, Benveniste J, Ninio E. Biosynthesis of paf-acether. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. Biochem Biophys Res Commun. 1989;162:475-482.
19. Korth R, Bidault J, Palmantier R, Benveniste J, Ninio E. Human platelets release a paf-acether: acetylhydrolase similar to that in plasma. Lipids. 1993;28:193-199.
20. Stafforini DM, Rollins EN, Prescott SM, McIntyre TM. The platelet-activating factor acetylhydrolase from human erythrocytes: purification and properties. J Biol Chem. 1993;268:3857-3865.