-
1
-
-
33645104321
-
Dual effect of flurbiprofen on cell proliferation and agonist-induced Ca(2+) movement in human osteosarcoma cells
-
Tseng LL, Cheng HH, Huang CJ, Liu SI, Kuo CC, Chen WC, Huangm JK, Hsu SS, Chang HT, Kao CH, Ho CM, Jan CR. Dual effect of flurbiprofen on cell proliferation and agonist-induced Ca(2+) movement in human osteosarcoma cells. Basic Clin Pharmacol Toxicol 2006; 98: 160-7.
-
(2006)
Basic Clin Pharmacol Toxicol
, vol.98
, pp. 160-167
-
-
Tseng, L.L.1
Cheng, H.H.2
Huang, C.J.3
Liu, S.I.4
Kuo, C.C.5
Chen, W.C.6
Huangm, J.K.7
Hsu, S.S.8
Chang, H.T.9
Kao, C.H.10
Ho, C.M.11
Jan, C.R.12
-
2
-
-
76249117703
-
R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction
-
Jin H, Wang Z, Liu L, Gao L, Sun L, Li X, Zhao H, Pan Y, Shi H, Liu N, Hong L, Liang J, Wu Q, Yang Z, Wu K, Fan D. R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm 2010; 7: 156-68.
-
(2010)
Mol Pharm
, vol.7
, pp. 156-168
-
-
Jin, H.1
Wang, Z.2
Liu, L.3
Gao, L.4
Sun, L.5
Li, X.6
Zhao, H.7
Pan, Y.8
Shi, H.9
Liu, N.10
Hong, L.11
Liang, J.12
Wu, Q.13
Yang, Z.14
Wu, K.15
Fan, D.16
-
3
-
-
0030880514
-
R-flurbiprofen chemo prevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: Implications for prophylaxis and treatment of colon cancer
-
Wechter WJ, Kantoci D, Murray Jr ED, Quiggle DD, Leipold DD, Gibson KM, McCracken JD. R-flurbiprofen chemo prevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer. Cancer Res 1997; 57: 4316-24.
-
(1997)
Cancer Res
, vol.57
, pp. 4316-4324
-
-
Wechter, W.J.1
Kantoci, D.2
Murray Jr., E.D.3
Quiggle, D.D.4
Leipold, D.D.5
Gibson, K.M.6
McCracken, J.D.7
-
4
-
-
0034655083
-
E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse
-
Wechter WJ, Leipold DD, Murray Jr ED, Quiggle D, Mc-Cracken JD, Barrios RS, Greenberg NM. E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Cancer Res 2000; 60: 2203-8.
-
(2000)
Cancer Res
, vol.60
, pp. 2203-2208
-
-
Wechter, W.J.1
Leipold, D.D.2
Murray Jr., E.D.3
Quiggle, D.4
Mc-Cracken, J.D.5
Barrios, R.S.6
Greenberg, N.M.7
-
5
-
-
0034645722
-
Treatment and survival study in the C57BL/6J-APC(Min)/+(Min) mouse with R-flurbiprofen
-
Wechter WJ, Murray Jr ED, Kantoci D, Quiggle DD, Leipold DD, Gibson KM, McCracken JD. Treatment and survival study in the C57BL/6J-APC(Min)/+(Min) mouse with R-flurbiprofen. Life Sci 2000; 66: 745-53.
-
(2000)
Life Sci
, vol.66
, pp. 745-753
-
-
Wechter, W.J.1
Murray Jr., E.D.2
Kantoci, D.3
Quiggle, D.D.4
Leipold, D.D.5
Gibson, K.M.6
McCracken, J.D.7
-
6
-
-
0038604334
-
Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers
-
Grosch S, Tegeder I, Schilling K, Maier TJ, Niederberger E, Geisslinger G. Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FA SEB J 2003; 17: 1316-8.
-
(2003)
FA SEB J
, vol.17
, pp. 1316-1318
-
-
Grosch, S.1
Tegeder, I.2
Schilling, K.3
Maier, T.J.4
Niederberger, E.5
Geisslinger, G.6
-
7
-
-
34548385246
-
Biological activities of hydrazone derivatives
-
Rollas S, Küçükgüzel ŞG. Biological activities of hydrazone derivatives. Molecules 2007; 12: 1910-39.
-
(2007)
Molecules
, vol.12
, pp. 1910-1939
-
-
Rollas, S.1
Küçükgüzel, S.G.2
-
8
-
-
33751032349
-
Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity
-
Koçyiǧit-Kaymakçi{dotless}oǧlu B, Oruç E, Ünsalan S, Kandemirli F, Shvets N, Rollas S, Anatholy D. Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. Eur J Med Chem 2006; 41: 1253-61.
-
(2006)
Eur J Med Chem
, vol.41
, pp. 1253-1261
-
-
Koçyiǧit-Kaymakçioǧlu, B.1
Oruç, E.2
Ünsalan, S.3
Kandemirli, F.4
Shvets, N.5
Rollas, S.6
Anatholy, D.7
-
9
-
-
33847367669
-
Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives
-
Gürsoy E, Ulusoy Gü zeldemirci N. Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives. Eur J Med Chem 2007; 42: 320-6.
-
(2007)
Eur J Med Chem
, vol.42
, pp. 320-326
-
-
Gürsoy, E.1
Ulusoy Gü Zeldemirci, N.2
-
10
-
-
80054852740
-
Synthesis of some novel hydrazone derivatives and evaluation of their antituberculosis activity
-
Özdemir A, Kaplanci{dotless}kli{dotless} ZA, Turan-Zitouni1 G, Revial G. Synthesis of some novel hydrazone derivatives and evaluation of their antituberculosis activity. Marmara Pharm J 2010; 14: 79-83.
-
(2010)
Marmara Pharm J
, vol.14
, pp. 79-83
-
-
Özdemir, A.1
Kaplancikli, Z.A.2
Turan-Zitouni, G.3
Revial, G.4
-
11
-
-
85080334602
-
Synthesis and biological activity of (±)-2-(2-Fluoro-4-biphenylyl) propanoic acid hydrazide derivatives
-
İstanbul-TURKEY, June 9-12
-
Tatar E, Çi{dotless}kla P, Küçükgüzel ŞG, Küçükgüzel İ, Şahin F, Yurdakul D, Kaushik-Basu N, Krishnan R. Synthesis and biological activity of (±)-2-(2-Fluoro-4-biphenylyl) propanoic acid hydrazide derivatives. Third International Meeting on Pharmacy & Pharmaceutical Sciences, İstanbul-TURKEY, June 9-12, 2010; p. 98.
-
(2010)
Third International Meeting on Pharmacy & Pharmaceutical Sciences
, pp. 98
-
-
Tatar, E.1
Çikla, P.2
Küçükgüzel, S.G.3
Küçükgüzel, I.4
Şahin, F.5
Yurdakul, D.6
Kaushik-Basu, N.7
Krishnan, R.8
-
12
-
-
0003155051
-
The rapid synthesis of organic compounds in microwave ovens
-
Gedye RN, Smith FE, Westaway KC. The rapid synthesis of organic compounds in microwave ovens. Can J Chem 1988; 66: 17-26.
-
(1988)
Can J Chem
, vol.66
, pp. 17-26
-
-
Gedye, R.N.1
Smith, F.E.2
Westaway, K.C.3
-
13
-
-
12344305106
-
The Application of Microwaves in Combinatorial and High-Throughput Synthesis as New Synthetic Procedure in Drug Discovery
-
Santagada V, Frecentese F, Perissutti E, Favretto L, Caliendo G. The Application of Microwaves in Combinatorial and High-Throughput Synthesis as New Synthetic Procedure in Drug Discovery. QSAR Comb Sci 2004; 23: 919-44.
-
(2004)
QSAR Comb Sci
, vol.23
, pp. 919-944
-
-
Santagada, V.1
Frecentese, F.2
Perissutti, E.3
Favretto, L.4
Caliendo, G.5
-
14
-
-
85080453321
-
-
Stoe & Cie, Darmstadt, Germany
-
Stoe & Cie X-AREA and X-RED32. Stoe & Cie, Darmstadt, Germany, 2002.
-
(2002)
Stoe & Cie X-AREA and X-RED32
-
-
-
15
-
-
0242560405
-
SIR97: A new tool for crystal structure determination and refinement
-
Altomare A, Burla MC, Camalli M, Cascarano GL, Giacovazzo C, Guagliardi A, Moliterni AGG, Polidori G, Spagna RJ. SIR97: A new tool for crystal structure determination and refinement. Appl Cryst 1999; 32: 115-9.
-
(1999)
Appl Cryst
, vol.32
, pp. 115-119
-
-
Altomare, A.1
Burla, M.C.2
Camalli, M.3
Cascarano, G.L.4
Giacovazzo, C.5
Guagliardi, A.6
Moliterni, A.G.G.7
Polidori, G.8
Spagna, R.J.9
-
16
-
-
37549039510
-
A short history of SHE LX
-
Sheldrick GM. A short history of SHE LX. Acta Cryst 2008; A64: 112-22.
-
(2008)
Acta Cryst
, vol.A64
, pp. 112-122
-
-
Sheldrick, G.M.1
-
17
-
-
33646767009
-
ORTEP-3 for Windows-a version of ORTEPIII with a Graphical User Interfa ce (GUI)
-
Farrugia LJ. ORTEP-3 for Windows-a version of ORTEPIII with a Graphical User Interfa ce (GUI). J Appl Cryst 1997; 30: 565.
-
(1997)
J Appl Cryst
, vol.30
, pp. 565
-
-
Farrugia, L.J.1
-
18
-
-
0141452964
-
WinGX suite for small-molecule single-crystal crystallography
-
Farrugia LJ. WinGX suite for small-molecule single-crystal crystallography. J Appl Cryst 1999; 32:837-8.
-
(1999)
J Appl Cryst
, vol.32
, pp. 837-838
-
-
Farrugia, L.J.1
-
19
-
-
16244396414
-
Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents
-
Amir M, Kumar S. Synthesis of some new 2-(2-fluoro-4-biphenylyl)propionic acid derivatives as potential anti-inflammatory agents. Pharmazie 2005; 60: 175-80.
-
(2005)
Pharmazie
, vol.60
, pp. 175-180
-
-
Amir, M.1
Kumar, S.2
-
20
-
-
84965822602
-
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
-
Alley MC, Scudiero DA, Monks PA, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988; 48: 589-601.
-
(1988)
Cancer Res
, vol.48
, pp. 589-601
-
-
Alley, M.C.1
Scudiero, D.A.2
Monks, P.A.3
Hursey, M.L.4
Czerwinski, M.J.5
Fine, D.L.6
Abbott, B.J.7
Mayo, J.G.8
Shoemaker, R.H.9
Boyd, M.R.10
-
22
-
-
0028906786
-
Some practical considerations and applications of The Nationa Cancer Institute in vitro anticancer drug discovery screen
-
Boyd MR, Paul KD. Some practical considerations and applications of The Nationa Cancer Institute in vitro anticancer drug discovery screen. Drug Dev Res 1995: 34; 91-109.
-
(1995)
Drug Dev Res
, vol.34
, pp. 91-109
-
-
Boyd, M.R.1
Paul, K.D.2
-
23
-
-
70350347384
-
Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor
-
Chen Y, Bopda-Waffo A, Basu A, Krishnan R, Silberstein E, Taylor DR, Talele TT, Arora P, Kaushik-Basu N. Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor. Antivir Chem Chemother 2009; 20: 19-36.
-
(2009)
Antivir Chem Chemother
, vol.20
, pp. 19-36
-
-
Chen, Y.1
Bopda-Waffo, A.2
Basu, A.3
Krishnan, R.4
Silberstein, E.5
Taylor, D.R.6
Talele, T.T.7
Arora, P.8
Kaushik-Basu, N.9
-
24
-
-
42649110011
-
4-Thiazolidinones: A novel class of hepatitis C virus NS5B polymerase inhibitors
-
Kaushik-Basu N, Bopda-Waffo A, Talele TT, Basu A, Chen Y, Küçükgüzel ŞG. 4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors. Front Biosci 2008; 13: 3857-68.
-
(2008)
Front Biosci
, vol.13
, pp. 3857-3868
-
-
Kaushik-Basu, N.1
Bopda-Waffo, A.2
Talele, T.T.3
Basu, A.4
Chen, Y.5
Küçükgüzel, S.G.6
-
25
-
-
41149136756
-
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors
-
Kaushik-Basu N, Bopda-Waffo A, Talele TT, Basu A, Costa PR, da Silva AJ, Sarafianos SG, Noel F. Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors. Nucleic Acids Res 2008; 36: 1482-96.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1482-1496
-
-
Kaushik-Basu, N.1
Bopda-Waffo, A.2
Talele, T.T.3
Basu, A.4
Costa, P.R.5
da Silva, A.J.6
Sarafianos, S.G.7
Noel, F.8
-
26
-
-
78651071881
-
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6Hindolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
-
Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6Hindolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem 2011; 54: 289-301.
-
(2011)
J Med Chem
, vol.54
, pp. 289-301
-
-
Narjes, F.1
Crescenzi, B.2
Ferrara, M.3
Habermann, J.4
Colarusso, S.5
Ferreira Mdel, R.6
Stansfield, I.7
McKay, A.C.8
Conte, I.9
Ercolani, C.10
Zaramella, S.11
Palumbi, M.C.12
Meuleman, P.13
Leroux-Roels, G.14
Giuliano, C.15
Fiore, F.16
di Marco, S.17
Baiocco, P.18
Koch, U.19
Migliaccio, G.20
Altamura, S.21
Laufer, R.22
De Francesco, R.23
Rowley, M.24
more..
-
27
-
-
64349088294
-
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
-
Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. J Med Chem 2009; 52: 1255-8.
-
(2009)
J Med Chem
, vol.52
, pp. 1255-1258
-
-
Li, H.1
Tatlock, J.2
Linton, A.3
Gonzalez, J.4
Jewell, T.5
Patel, L.6
Ludlum, S.7
Drowns, M.8
Rahavendran, S.V.9
Skor, H.10
Hunter, R.11
Shi, S.T.12
Herlihy, K.J.13
Parge, H.14
Hickey, M.15
Yu, X.16
Chau, F.17
Nonomiya, J.18
Lewis, C.19
-
28
-
-
33847771635
-
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate
-
Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate. J Med Chem 2007; 50: 897-900.
-
(2007)
J Med Chem
, vol.50
, pp. 897-900
-
-
Slater, M.J.1
Amphlett, E.M.2
Andrews, D.M.3
Bravi, G.4
Burton, G.5
Cheasty, A.G.6
Corfield, J.A.7
Ellis, M.R.8
Fenwick, R.H.9
Fernandes, S.10
Guidetti, R.11
Haigh, D.12
Hartley, C.D.13
Howes, P.D.14
Jackson, D.L.15
Jarvest, R.L.16
Lovegrove, V.L.17
Medhurst, K.J.18
Parry, N.R.19
Price, H.20
Shah, P.21
Singh, O.M.22
Stocker, R.23
Thommes, P.24
Wilkinson, C.25
Wonacott, A.26
more..
-
29
-
-
67650156483
-
Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus
-
Hang JQ, Yang Y, Harris SF, Leveque V, Whittington HJ, Rajyaguru S, Ao-Ieong G, McCown MF, Wong A, Giannetti AM, Le Pogam S, Talamas F, Cammack N, Najera I, Klumpp K. Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J Biol Chem 2009; 284: 15517-29.
-
(2009)
J Biol Chem
, vol.284
, pp. 15517-15529
-
-
Hang, J.Q.1
Yang, Y.2
Harris, S.F.3
Leveque, V.4
Whittington, H.J.5
Rajyaguru, S.6
Ao-Ieong, G.7
McCown, M.F.8
Wong, A.9
Giannetti, A.M.10
le Pogam, S.11
Talamas, F.12
Cammack, N.13
Najera, I.14
Klumpp, K.15
-
30
-
-
0034236220
-
Synthesis and structure of hydrazones obtained from hydrazides of [5-(4-pyridyl)-1,3,4-oxadiazol-2-ylthio]acetic or 2-[5-(4-pyridyl)-1,3,4-oxadiazol-2-ylthio]propionic acids
-
Rutavichyus A, Valiulene S, Kuodis Z. Synthesis and structure of hydrazones obtained from hydrazides of [5-(4-pyridyl)-1,3,4-oxadiazol-2-ylthio]acetic or 2-[5-(4-pyridyl)-1,3,4-oxadiazol-2-ylthio]propionic acids. Chem Heterocycl Compds 2000; 36:851-6.
-
(2000)
Chem Heterocycl Compds
, vol.36
, pp. 851-856
-
-
Rutavichyus, A.1
Valiulene, S.2
Kuodis, Z.3
-
31
-
-
0344875120
-
Synthesis and biological activities of diflunisal hydra zide-hydrazones
-
Küçükgüzel ŞG, Mazi A, Şahin F, Öztürk S, Stables, J. Synthesis and biological activities of diflunisal hydra zide-hydrazones. Eur J Med Chem 2003; 38: 1005-13.
-
(2003)
Eur J Med Chem
, vol.38
, pp. 1005-1013
-
-
Küçükgüzel, S.G.1
Mazi, A.2
Şahin, F.3
Öztürk, S.4
Stables, J.5
-
32
-
-
0036501101
-
Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds
-
Küçükgüzel ŞG, Oruç EE, Rollas S, Şahin F, Özbek A. Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds. Eur J Med Chem 2002; 37: 197-206.
-
(2002)
Eur J Med Chem
, vol.37
, pp. 197-206
-
-
Küçükgüzel, S.G.1
Oruç, E.E.2
Rollas, S.3
Şahin, F.4
Özbek, A.5
|