-
1
-
-
0031040238
-
Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: A randomised multicentre study of active disease using MRI and clinical criteria
-
Edan G, Miller D, Clanet M, et al. Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. J Neurol Neurosurg Psychiatry 1997;62:112-118.
-
(1997)
J Neurol Neurosurg Psychiatry
, vol.62
, pp. 112-118
-
-
Edan, G.1
Miller, D.2
Clanet, M.3
-
2
-
-
0037153729
-
Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, double-blind, randomised, multicentre trial
-
Hartung HP, Gonsette R, Konig N, et al. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial. Lancet 2002;360:2018-2025.
-
(2002)
Lancet
, vol.360
, pp. 2018-2025
-
-
Hartung, H.P.1
Gonsette, R.2
Konig, N.3
-
3
-
-
8044242916
-
Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome
-
Millefìorini E, Gasperini C, Pozzilli C, et al. Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome. J Neurol 1997;244:153-159.
-
(1997)
J Neurol
, vol.244
, pp. 153-159
-
-
Millefìorini, E.1
Gasperini, C.2
Pozzilli, C.3
-
4
-
-
0035707562
-
A double-blind clinical trial of mitoxantrone versus methylprednisolone in relapsing, secondary progressive multiple sclerosis
-
Van De Wyngaert FA, Beguin C, D'Hooghe MB, et al. A double-blind clinical trial of mitoxantrone versus methylprednisolone in relapsing, secondary progressive multiple sclerosis. Acta Neurol Belg 2001;101:210-216.
-
(2001)
Acta Neurol Belg
, vol.101
, pp. 210-216
-
-
Van De Wyngaert, F.A.1
Beguin, C.2
D'Hooghe, M.B.3
-
5
-
-
11244349904
-
Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients
-
Chan A, Weilbach FX, Toyka KV, Gold R. Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients. Clin Exp Immunol 2005;139:152-158.
-
(2005)
Clin Exp Immunol
, vol.139
, pp. 152-158
-
-
Chan, A.1
Weilbach, F.X.2
Toyka, K.V.3
Gold, R.4
-
6
-
-
20444434782
-
Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro
-
Neuhaus O, Wiendl H, Kieseier BC, et al. Multiple sclerosis: mitoxantrone promotes differential effects on immunocompetent cells in vitro. J Neuroimmunol 2005;168:128-137.
-
(2005)
J Neuroimmunol
, vol.168
, pp. 128-137
-
-
Neuhaus, O.1
Wiendl, H.2
Kieseier, B.C.3
-
7
-
-
33751010179
-
Kieseier BC. Inhibition by mitoxantrone of in vitro migration of immunocompetent cells: A possible mechanism for therapeutic efficacy in the treatment of multiple sclerosis
-
Kopadze T, Dehmel T, Hartung HP, Stuve O. Kieseier BC. Inhibition by mitoxantrone of in vitro migration of immunocompetent cells: a possible mechanism for therapeutic efficacy in the treatment of multiple sclerosis. Arch Neurol 2006;63:1572-1578.
-
(2006)
Arch Neurol
, vol.63
, pp. 1572-1578
-
-
Kopadze, T.1
Dehmel, T.2
Hartung, H.P.3
Stuve, O.4
-
8
-
-
58249085252
-
Frequency and risk factors of mitoxantrone-induced amenorrhea in multiple sclerosis: The FEMIMS study
-
Cocco E, Sardu C, Gallo P, et al. Frequency and risk factors of mitoxantrone-induced amenorrhea in multiple sclerosis: the FEMIMS study. Mult Scler 2008;14:1225-1233.
-
(2008)
Mult Scler
, vol.14
, pp. 1225-1233
-
-
Cocco, E.1
Sardu, C.2
Gallo, P.3
-
9
-
-
0037167538
-
Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS
-
Ghalie RG, Edan G, Laurent M, et al. Cardiac adverse effects associated with mitoxantrone (Novantrone) therapy in patients with MS. Neurology 2002;59:909-913.
-
(2002)
Neurology
, vol.59
, pp. 909-913
-
-
Ghalie, R.G.1
Edan, G.2
Laurent, M.3
-
10
-
-
0036783808
-
A study of therapyrelated acute leukaemia after mitoxantrone therapy for multiple sclerosis
-
Ghalie RG, Mauch E, Edan G, et al. A study of therapyrelated acute leukaemia after mitoxantrone therapy for multiple sclerosis. Mult Scler 2002;8:441-445.
-
(2002)
Mult Scler
, vol.8
, pp. 441-445
-
-
Ghalie, R.G.1
Mauch, E.2
Edan, G.3
-
11
-
-
77951828930
-
Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
-
Marriott JJ, Miyasaki JM, Gronseth G, O'Connor PW. Evidence Report: the efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2010;74:1463-1470.
-
(2010)
Neurology
, vol.74
, pp. 1463-1470
-
-
Marriott, J.J.1
Miyasaki, J.M.2
Gronseth, G.3
O'Connor, P.W.4
-
12
-
-
70450176057
-
Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required
-
Pascual AM, Tellez N, Bosca I, et al. Revision of the risk of secondary leukaemia after mitoxantrone in multiple sclerosis populations is required. Mult Scler 2009;15:1303-1310.
-
(2009)
Mult Scler
, vol.15
, pp. 1303-1310
-
-
Pascual, A.M.1
Tellez, N.2
Bosca, I.3
-
13
-
-
82955225355
-
Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
-
Martinelli V, Cocco E, Capra R, et al. Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone. Neurology 2011;77:1887-1895.
-
(2011)
Neurology
, vol.77
, pp. 1887-1895
-
-
Martinelli, V.1
Cocco, E.2
Capra, R.3
-
14
-
-
84858662103
-
Incidence of therapy-related acute leukaemia in mitoxantrone-treated multiple sclerosis patients in Germany
-
Stroet A, Hemmelmann C, Starck M, et al. Incidence of therapy-related acute leukaemia in mitoxantrone-treated multiple sclerosis patients in Germany. Ther Adv Neurol Disord 2012;5:75-79.
-
(2012)
Ther Adv Neurol Disord
, vol.5
, pp. 75-79
-
-
Stroet, A.1
Hemmelmann, C.2
Starck, M.3
-
15
-
-
79959520067
-
French Mitoxantrone Safety Group. Long-term safety profile of mitoxantrone in a French cohort of 802 multiple sclerosis patients: A 5-year prospective study
-
Le Page E, Leray E, Edan G; French Mitoxantrone Safety Group. Long-term safety profile of mitoxantrone in a French cohort of 802 multiple sclerosis patients: a 5-year prospective study. Mult Scler 2011;17:867-875.
-
(2011)
Mult Scler
, vol.17
, pp. 867-875
-
-
Le Page, E.1
Leray, E.2
Edan, G.3
-
16
-
-
84860317152
-
Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
-
Stroet A, Gold R, Chan A. Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone. Neurology 2012;78:933-934.
-
(2012)
Neurology
, vol.78
, pp. 933-934
-
-
Stroet, A.1
Gold, R.2
Chan, A.3
-
17
-
-
78049462007
-
Mitoxantrone for worsening multiple sclerosis: Tolerability, toxicity, adherence and efficacy in the clinical setting
-
Wundes A, Kraft GH, Bowen JD, Gooley TA, Nash RA. Mitoxantrone for worsening multiple sclerosis: tolerability, toxicity, adherence and efficacy in the clinical setting. Clin Neurol Neurosurg 2010;112:876-882.
-
(2010)
Clin Neurol Neurosurg
, vol.112
, pp. 876-882
-
-
Wundes, A.1
Kraft, G.H.2
Bowen, J.D.3
Gooley, T.A.4
Nash, R.A.5
-
18
-
-
0037441489
-
Mitoxantrone in progressive multiple sclerosis: When and how to treat?
-
Gonsette RE. Mitoxantrone in progressive multiple sclerosis: when and how to treat? J Neurol Sci 2003;206:203-208.
-
(2003)
J Neurol Sci
, vol.206
, pp. 203-208
-
-
Gonsette, R.E.1
-
19
-
-
80855131644
-
Mitoxantrone prior to interferon beta-1b in aggressive relapsing multiple sclerosis: A 3-year randomised trial
-
Edan G, Comi G, Le PE, Leray E, Rocca MA, Filippi M. Mitoxantrone prior to interferon beta-1b in aggressive relapsing multiple sclerosis: a 3-year randomised trial. J Neurol Neurosurg Psychiatry 2011;82:1344-1350.
-
(2011)
J Neurol Neurosurg Psychiatry
, vol.82
, pp. 1344-1350
-
-
Edan, G.1
Comi, G.2
Le, P.E.3
Leray, E.4
Rocca, M.A.5
Filippi, M.6
-
20
-
-
79953199080
-
Risk of acute promyelocytic leukemia in multiple sclerosis: Coding variants of DNA repair genes
-
Hasan SK, Buttari F, Ottone T, et al. Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes. Neurology 2011;76:1059-1065.
-
(2011)
Neurology
, vol.76
, pp. 1059-1065
-
-
Hasan, S.K.1
Buttari, F.2
Ottone, T.3
-
21
-
-
64649090292
-
Targeting DNA topoisomerase II in cancer chemotherapy
-
Nitiss JL. Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer 2009;9:338-350.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 338-350
-
-
Nitiss, J.L.1
-
22
-
-
20144388623
-
DNA topoisomerase II in therapy-related acute promyelocytic leukemia
-
Mistry AR, Felix CA, Whitmarsh RJ, et al. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med 2005;352:1529-1538.
-
(2005)
N Engl J Med
, vol.352
, pp. 1529-1538
-
-
Mistry, A.R.1
Felix, C.A.2
Whitmarsh, R.J.3
-
23
-
-
0033628701
-
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
-
Fortune JM, Osheroff N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog Nucleic Acid Res Mol Biol 2000;64:221-253.
-
(2000)
Prog Nucleic Acid Res Mol Biol
, vol.64
, pp. 221-253
-
-
Fortune, J.M.1
Osheroff, N.2
-
24
-
-
54049153246
-
Molecular analysis of t (15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis
-
Hasan SK, Mays AN, Ottone T, et al. Molecular analysis of t (15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood 2008;112:3383-3390.
-
(2008)
Blood
, vol.112
, pp. 3383-3390
-
-
Hasan, S.K.1
Mays, A.N.2
Ottone, T.3
-
25
-
-
75649084232
-
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t (15;17) therapy-related acute promyelocytic leukemia
-
Mays AN, Osheroff N, Xiao Y, et al. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t (15;17) therapy-related acute promyelocytic leukemia. Blood 2010;115:326-330.
-
(2010)
Blood
, vol.115
, pp. 326-330
-
-
Mays, A.N.1
Osheroff, N.2
Xiao, Y.3
-
26
-
-
77958551737
-
Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination
-
De Campos-Nebel M, Larripa I, Gonzalez-Cid M. Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination. PLoS One 2010;5.
-
(2010)
PLoS One
, vol.5
-
-
De Campos-Nebel, M.1
Larripa, I.2
Gonzalez-Cid, M.3
-
27
-
-
74249113947
-
Mitoxantrone and cytotoxic drugs' mechanisms of action
-
Vollmer T, Stewart T, Baxter N. Mitoxantrone and cytotoxic drugs' mechanisms of action. Neurology 2010;74(suppl 1):S41-S46.
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 1
-
-
Vollmer, T.1
Stewart, T.2
Baxter, N.3
-
28
-
-
0036197483
-
International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: Overview report
-
Rowley JD, Olney HJ. International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: overview report. Genes Chromosomes Cancer 2002;33:331-345.
-
(2002)
Genes Chromosomes Cancer
, vol.33
, pp. 331-345
-
-
Rowley, J.D.1
Olney, H.J.2
-
30
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu LF. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 1989;58:351-375.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
-
31
-
-
0021749639
-
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
-
Chen GL, Yang L, Rowe TC, Halligan BD, Tewey KM, Liu LF. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 1984;259:13560-13566.
-
(1984)
J Biol Chem
, vol.259
, pp. 13560-13566
-
-
Chen, G.L.1
Yang, L.2
Rowe, T.C.3
Halligan, B.D.4
Tewey, K.M.5
Liu, L.F.6
-
32
-
-
71549134054
-
ABC-transporter genepolymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis
-
Cotte S, Von AN, Kruse N, et al. ABC-transporter genepolymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain 2009;132:2517-2530.
-
(2009)
Brain
, vol.132
, pp. 2517-2530
-
-
Cotte, S.1
Von, A.N.2
Kruse, N.3
-
33
-
-
70349667038
-
Severe cardiac failure in a patient with multiple sclerosis following low-dose mitoxantrone treatment
-
Dorr J, Bitsch A, Schmailzl KJ, et al. Severe cardiac failure in a patient with multiple sclerosis following low-dose mitoxantrone treatment. Neurology 2009;73:991-993.
-
(2009)
Neurology
, vol.73
, pp. 991-993
-
-
Dorr, J.1
Bitsch, A.2
Schmailzl, K.J.3
-
34
-
-
79953888314
-
Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis
-
Ammatuna E, Montesinos P, Hasan SK, et al. Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis. Haematologica 2011;96:621-625.
-
(2011)
Haematologica
, vol.96
, pp. 621-625
-
-
Ammatuna, E.1
Montesinos, P.2
Hasan, S.K.3
-
35
-
-
0033214651
-
Therapy of molecular relapse in acute promyelocytic leukemia
-
Lo Coco F, Diverio D, Avvisati G, et al. Therapy of molecular relapse in acute promyelocytic leukemia. Blood 1999;94:2225-2229.
-
(1999)
Blood
, vol.94
, pp. 2225-2229
-
-
Lo Coco, F.1
Diverio, D.2
Avvisati, G.3
-
36
-
-
33847178763
-
Outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): Benefit of an early intervention
-
Esteve J, Escoda L, Martin G, et al. Outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): benefit of an early intervention. Leukemia 2007;21:446-452.
-
(2007)
Leukemia
, vol.21
, pp. 446-452
-
-
Esteve, J.1
Escoda, L.2
Martin, G.3
-
37
-
-
83255181788
-
Pharmacogenomics in neurology: Current state and future steps
-
Chan A, Pirmohamed M, Comabella M. Pharmacogenomics in neurology: current state and future steps. Ann Neurol 2011;70:684-697.
-
(2011)
Ann Neurol
, vol.70
, pp. 684-697
-
-
Chan, A.1
Pirmohamed, M.2
Comabella, M.3
|