메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages 123-131

Novel therapeutic strategies in adult acute lymphoblastic leukemia - A focus on emerging monoclonal antibodies

Author keywords

Acute lymphoblastic leukemia; Alemtuzumab; Blinatumomab; Epratuzumab; Inotuzumab; Monoclonal antibody; Moxetumomab; Ofatumumab; Rituximab

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; ASPARAGINASE; BACTERIAL TOXIN; BL 22; CAT 3888; CD20 ANTIGEN; CD52 ANTIGEN; CD59 ANTIGEN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DECAY ACCELERATING FACTOR; DEXAMETHASONE; DOXORUBICIN; EPRATUZUMAB; FLUDARABINE; INOTUZUMAB OZOGAMICIN; MERCAPTOPURINE; METHOTREXATE; MONOCLONAL ANTIBODY; MOXETUMOMAB PASUDOTOX; OFATUMUMAB; PREDNISONE; PROTEIN BAK; PROTEIN BAX; RITUXIMAB; SAR 3419; STEROID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

EID: 84878766334     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-013-0160-7     Document Type: Article
Times cited : (14)

References (92)
  • 1
    • 33645526144 scopus 로고    scopus 로고
    • Cancer statistics, 2006
    • 16514137 10.3322/canjclin.56.2.106
    • Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106-30.
    • (2006) CA Cancer J Clin , vol.56 , pp. 106-130
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • 9718381 10.1056/NEJM199808273390907 1:STN:280:DyaK1cznt1CmsQ%3D%3D
    • Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med. 1998;339:605-15.
    • (1998) N Engl J Med , vol.339 , pp. 605-615
    • Pui, C.H.1    Evans, W.E.2
  • 3
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • 16407512 10.1056/NEJMra052603 1:CAS:528:DC%2BD28XisFWksQ%3D%3D
    • Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166-78.
    • (2006) N Engl J Med , vol.354 , pp. 166-178
    • Pui, C.H.1    Evans, W.E.2
  • 4
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • 18358930 10.1016/S0140-6736(08)60457-2 1:CAS:528:DC%2BD1cXjs1SltbY%3D
    • Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371:1030-43.
    • (2008) Lancet , vol.371 , pp. 1030-1043
    • Pui, C.H.1    Robison, L.L.2    Look, A.T.3
  • 7
    • 77149133679 scopus 로고    scopus 로고
    • Adult acute lymphoblastic leukemia: Concepts and strategies
    • 20101737 10.1002/cncr.24862 1:CAS:528:DC%2BC3cXjs1GrtL8%3D
    • Faderl S, O'Brien S, Pui CH, et al. Adult acute lymphoblastic leukemia: concepts and strategies. Cancer. 2010;116:1165-76.
    • (2010) Cancer , vol.116 , pp. 1165-1176
    • Faderl, S.1    O'Brien, S.2    Pui, C.H.3
  • 8
    • 3042617874 scopus 로고    scopus 로고
    • The U.S. trials in adult acute lymphoblastic leukemia
    • 15124704
    • Larson RA. The U.S. trials in adult acute lymphoblastic leukemia. Ann Hematol. 2004;83 Suppl 1:S127-128.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1 , pp. 127-128
    • Larson, R.A.1
  • 9
    • 8644242365 scopus 로고    scopus 로고
    • Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: A GOELAMS trial
    • 15256423 10.1182/blood-2003-10-3560 1:CAS:528:DC%2BD2cXhtVWhur%2FP
    • Hunault M, Harousseau JL, Delain M, et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial. Blood. 2004;104:3028-37.
    • (2004) Blood , vol.104 , pp. 3028-3037
    • Hunault, M.1    Harousseau, J.L.2    Delain, M.3
  • 10
    • 10044259800 scopus 로고    scopus 로고
    • Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia
    • 15481055 10.1002/cncr.20668 1:CAS:528:DC%2BD2MXivFOhuw%3D%3D
    • Kantarjian H, Thomas D, O'Brien S, et al. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer. 2004;101:2788-801.
    • (2004) Cancer , vol.101 , pp. 2788-2801
    • Kantarjian, H.1    Thomas, D.2    O'Brien, S.3
  • 12
    • 0033637411 scopus 로고    scopus 로고
    • Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL)
    • 11147225 10.1016/S0889-8588(05)70188-X 1:STN:280:DC%2BD3M3htFWgug%3D%3D ix
    • Gokbuget N, Hoelzer D, Arnold R, et al. Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol Oncol Clin North Am. 2000;14:1307-25. ix.
    • (2000) Hematol Oncol Clin North Am , vol.14 , pp. 1307-1325
    • Gokbuget, N.1    Hoelzer, D.2    Arnold, R.3
  • 13
    • 61849122810 scopus 로고    scopus 로고
    • Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century
    • 18974371 10.1182/blood-2008-06-164863 1:CAS:528:DC%2BD1MXitlCrt7k%3D
    • Pulte D, Gondos A, Brenner H. Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century. Blood. 2009;113:1408-11.
    • (2009) Blood , vol.113 , pp. 1408-1411
    • Pulte, D.1    Gondos, A.2    Brenner, H.3
  • 14
    • 28444490353 scopus 로고    scopus 로고
    • Induction therapy for adults with acute lymphoblastic leukemia: Results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
    • 16105981 10.1182/blood-2005-04-1623 1:CAS:528:DC%2BD2MXht12ksbnI
    • Rowe JM, Buck G, Burnett AK, et al. Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood. 2005;106:3760-7.
    • (2005) Blood , vol.106 , pp. 3760-3767
    • Rowe, J.M.1    Buck, G.2    Burnett, A.K.3
  • 15
    • 0034611661 scopus 로고    scopus 로고
    • Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • 10749961 10.1056/NEJM200004063421402 1:STN:280:DC%2BD3c7ptlWmsw%3D%3D
    • Arico M, Valsecchi MG, Camitta B, et al. Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. N Engl J Med. 2000;342:998-1006.
    • (2000) N Engl J Med , vol.342 , pp. 998-1006
    • Arico, M.1    Valsecchi, M.G.2    Camitta, B.3
  • 16
    • 60949101218 scopus 로고    scopus 로고
    • Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: The GRAALL-2003 study
    • 10.1200/JCO.2008.18.6916 1:CAS:528:DC%2BD1MXjs1Kntrc%3D
    • Huguet F, Leguay T, Raffoux E, et al. Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: the GRAALL-2003 study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2009;27:911-8.
    • (2009) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.27 , pp. 911-918
    • Huguet, F.1    Leguay, T.2    Raffoux, E.3
  • 17
    • 67049098987 scopus 로고    scopus 로고
    • Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen
    • 19438471 10.1111/j.1365-2141.2009.07712.x
    • Storring JM, Minden MD, Kao S, et al. Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen. British journal of haematology. 2009;146:76-85.
    • (2009) British Journal of Haematology , vol.146 , pp. 76-85
    • Storring, J.M.1    Minden, M.D.2    Kao, S.3
  • 18
    • 55749086565 scopus 로고    scopus 로고
    • Results of the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen in elderly patients with acute lymphocytic leukemia
    • 18720356 10.1002/cncr.23819
    • O'Brien S, Thomas DA, Ravandi F, et al. Results of the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen in elderly patients with acute lymphocytic leukemia. Cancer. 2008;113:2097-101.
    • (2008) Cancer , vol.113 , pp. 2097-2101
    • O'Brien, S.1    Thomas, D.A.2    Ravandi, F.3
  • 19
    • 27244447048 scopus 로고    scopus 로고
    • Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastic leukemia
    • 10.1200/JCO.2005.11.411 1:CAS:528:DC%2BD2MXhtFCrsbbF
    • Pession A, Valsecchi MG, Masera G, et al. Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastic leukemia. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2005;23:7161-7.
    • (2005) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.23 , pp. 7161-7167
    • Pession, A.1    Valsecchi, M.G.2    Masera, G.3
  • 20
    • 0036464686 scopus 로고    scopus 로고
    • Treatment of adult acute lymphoblastic leukemia (ALL): Long-term follow-up of the GIMEMA ALL 0288 randomized study
    • 11806988 10.1182/blood.V99.3.863 1:CAS:528:DC%2BD38XhtValsb4%3D
    • Annino L, Vegna ML, Camera A, et al. Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study. Blood. 2002;99:863-71.
    • (2002) Blood , vol.99 , pp. 863-871
    • Annino, L.1    Vegna, M.L.2    Camera, A.3
  • 21
    • 33748848125 scopus 로고    scopus 로고
    • Novel antibody-based therapy for acute lymphoblastic leukaemia
    • 16997178 10.1016/j.beha.2006.06.008
    • Gokbuget N, Hoelzer D. Novel antibody-based therapy for acute lymphoblastic leukaemia. Best Pract Res Clin Haematol. 2006;19:701-13.
    • (2006) Best Pract Res Clin Haematol , vol.19 , pp. 701-713
    • Gokbuget, N.1    Hoelzer, D.2
  • 22
    • 33645830511 scopus 로고    scopus 로고
    • Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia
    • 16502413 10.1002/cncr.21776 1:CAS:528:DC%2BD28XjsFeru78%3D
    • Thomas DA, Faderl S, O'Brien S, et al. Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Cancer. 2006;106:1569-80.
    • (2006) Cancer , vol.106 , pp. 1569-1580
    • Thomas, D.A.1    Faderl, S.2    O'Brien, S.3
  • 23
    • 1842424992 scopus 로고    scopus 로고
    • Treatment with monoclonal antibodies in acute lymphoblastic leukemia: Current knowledge and future prospects
    • 14648023 10.1007/s00277-003-0752-8
    • Gokbuget N, Hoelzer D. Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects. Ann Hematol. 2004;83:201-5.
    • (2004) Ann Hematol , vol.83 , pp. 201-205
    • Gokbuget, N.1    Hoelzer, D.2
  • 24
    • 70349748514 scopus 로고    scopus 로고
    • Monoclonal antibody therapy with rituximab for acute lymphoblastic leukemia
    • 19825447 10.1016/j.hoc.2009.07.005 Useful review highlighting improved outcomes and therapeutic benefit of adding rituximab to cytotoxic chemotherapy in patients with B-cell ALL
    • •• Thomas DA, O'Brien S, Kantarjian HM. Monoclonal antibody therapy with rituximab for acute lymphoblastic leukemia. Hematol Oncol Clin North Am. 2009;23:949-971, v. Useful review highlighting improved outcomes and therapeutic benefit of adding rituximab to cytotoxic chemotherapy in patients with B-cell ALL.
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 949-971
    • Thomas, D.A.1    O'Brien, S.2    Kantarjian, H.M.3
  • 25
    • 83355169607 scopus 로고    scopus 로고
    • Chemoimmunotherapy in acute lymphoblastic leukemia
    • 21958552 10.1016/j.blre.2011.08.001 1:CAS:528:DC%2BC3MXhsF2rt7%2FM
    • Hoelzer D, Gokbuget N. Chemoimmunotherapy in acute lymphoblastic leukemia. Blood Rev. 2012;26:25-32.
    • (2012) Blood Rev , vol.26 , pp. 25-32
    • Hoelzer, D.1    Gokbuget, N.2
  • 26
    • 81355128224 scopus 로고    scopus 로고
    • Efficacy and toxicity of rituximab and brief duration, High intensity chemotherapy with filgrastim support for Burkitt or Burkitt - Like leukemia/lymphoma: Cancer and Leukemia Group B (Calgb) Study 10002
    • Rizzieri DA, Johnson JL, Byrd JC, et al. Efficacy and toxicity of rituximab and brief duration, High intensity chemotherapy with filgrastim support for Burkitt or Burkitt - like leukemia/lymphoma: Cancer and Leukemia Group B (Calgb) Study 10002. Blood. 2010;116:374-5.
    • (2010) Blood , vol.116 , pp. 374-375
    • Rizzieri, D.A.1    Johnson, J.L.2    Byrd, J.C.3
  • 27
    • 77956240944 scopus 로고    scopus 로고
    • Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia
    • 10.1200/JCO.2009.26.9456 1:CAS:528:DC%2BC3cXhtFyhsrfI One of the foremost adult B-cell ALL studies highlighting the efficacy and benefit of chemoimmunotherapy with rituximab over chemotherapy alone
    • • Thomas DA, O'Brien S, Faderl S, et al. Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28:3880-9. One of the foremost adult B-cell ALL studies highlighting the efficacy and benefit of chemoimmunotherapy with rituximab over chemotherapy alone.
    • (2010) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.28 , pp. 3880-3889
    • Thomas, D.A.1    O'Brien, S.2    Faderl, S.3
  • 28
    • 79957455511 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab Improves molecular CR rate and outcome in CD20+B-lineage standard and high risk patients; Results of 263 CD20+patients studied prospectively in GMALL study 07/2003
    • Hoelzer D, Huettmann A, Kaul F, et al. Immunochemotherapy with rituximab Improves molecular CR rate and outcome in CD20+B-lineage standard and high risk patients; Results of 263 CD20+patients studied prospectively in GMALL study 07/2003. Blood. 2010;116:77-8.
    • (2010) Blood , vol.116 , pp. 77-78
    • Hoelzer, D.1    Huettmann, A.2    Kaul, F.3
  • 30
    • 80054037204 scopus 로고    scopus 로고
    • Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates
    • 21998010 10.1158/0008-5472.CAN-11-1374 1:CAS:528:DC%2BC3MXhtlSltLrM
    • FitzGerald DJ, Wayne AS, Kreitman RJ, et al. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer research. 2011;71:6300-9.
    • (2011) Cancer Research , vol.71 , pp. 6300-6309
    • Fitzgerald, D.J.1    Wayne, A.S.2    Kreitman, R.J.3
  • 31
    • 0034951864 scopus 로고    scopus 로고
    • Mechanism of action of rituximab
    • 11508930 1:CAS:528:DC%2BD3MXlsV2gs74%3D
    • Maloney DG. Mechanism of action of rituximab. Anticancer Drugs. 2001;12 Suppl 2:S1-4.
    • (2001) Anticancer Drugs , vol.12 , Issue.SUPPL. 2 , pp. 1-4
    • Maloney, D.G.1
  • 32
    • 0031837813 scopus 로고    scopus 로고
    • Levels of expression of CD19 and CD20 in chronic B cell leukaemias
    • 9708202 10.1136/jcp.51.5.364 1:STN:280:DyaK1czntlCqtA%3D%3D
    • Ginaldi L, De Martinis M, Matutes E, et al. Levels of expression of CD19 and CD20 in chronic B cell leukaemias. J Clin Pathol. 1998;51:364-9.
    • (1998) J Clin Pathol , vol.51 , pp. 364-369
    • Ginaldi, L.1    De Martinis, M.2    Matutes, E.3
  • 33
    • 79551641737 scopus 로고    scopus 로고
    • Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia
    • 21077738 10.3109/10428194.2010.529206
    • Piccaluga PP, Arpinati M, Candoni A, et al. Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia. Leuk Lymphoma. 2011;52:325-7.
    • (2011) Leuk Lymphoma , vol.52 , pp. 325-327
    • Piccaluga, P.P.1    Arpinati, M.2    Candoni, A.3
  • 34
    • 79957450612 scopus 로고    scopus 로고
    • Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: Analysis of 552 cases
    • 21348573 10.3109/10428194.2011.559668 1:CAS:528:DC%2BC3MXmtl2msLY%3D
    • Raponi S, De Propris MS, Intoppa S, et al. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases. Leuk Lymphoma. 2011;52:1098-107.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1098-1107
    • Raponi, S.1    De Propris, M.S.2    Intoppa, S.3
  • 35
    • 33847014608 scopus 로고    scopus 로고
    • Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy
    • 17283164 10.1158/0008-5472.CAN-06-2184 1:CAS:528:DC%2BD2sXht1yntrw%3D
    • Jazirehi AR, Vega MI, Bonavida B. Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy. Cancer research. 2007;67:1270-81.
    • (2007) Cancer Research , vol.67 , pp. 1270-1281
    • Jazirehi, A.R.1    Vega, M.I.2    Bonavida, B.3
  • 36
    • 67650594764 scopus 로고    scopus 로고
    • Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
    • 18703706 10.1182/blood-2008-04-151860 1:CAS:528:DC%2BD1MXnvFGnsrc%3D
    • Thomas DA, O'Brien S, Jorgensen JL, et al. Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia. Blood. 2009;113:6330-7.
    • (2009) Blood , vol.113 , pp. 6330-6337
    • Thomas, D.A.1    O'Brien, S.2    Jorgensen, J.L.3
  • 38
    • 76549108577 scopus 로고    scopus 로고
    • Adverse prognostic significance of CD20 expression in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia
    • 19773266 10.3324/haematol.2009.010306
    • Maury S, Huguet F, Leguay T, et al. Adverse prognostic significance of CD20 expression in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia. Haematologica. 2010;95:324-8.
    • (2010) Haematologica , vol.95 , pp. 324-328
    • Maury, S.1    Huguet, F.2    Leguay, T.3
  • 39
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • 11807147 10.1056/NEJMoa011795 1:CAS:528:DC%2BD38XmslGgsw%3D%3D
    • Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235-42.
    • (2002) N Engl J Med , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 40
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • 10.1200/JCO.2009.26.4556 1:CAS:528:DC%2BC3cXmtVyhurc%3D
    • Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28:1756-65.
    • (2010) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.28 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 41
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • 20888994 10.1016/S0140-6736(10)61381-5 1:CAS:528:DC%2BC3cXht1ersr%2FK
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376:1164-74.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 42
    • 77952630014 scopus 로고    scopus 로고
    • Modulation of antigen expression in B-cell precursor acute lymphoblastic leukemia during induction therapy is partly transient: Evidence for a drug-induced regulatory phenomenon. Results of the AIEOP-BFM-ALL-FLOW-MRD-Study Group
    • 20201055
    • Dworzak MN, Gaipa G, Schumich A, et al. Modulation of antigen expression in B-cell precursor acute lymphoblastic leukemia during induction therapy is partly transient: evidence for a drug-induced regulatory phenomenon. Results of the AIEOP-BFM-ALL-FLOW-MRD-Study Group. Cytometry B Clin Cytom. 2010;78:147-53.
    • (2010) Cytometry B Clin Cytom , vol.78 , pp. 147-153
    • Dworzak, M.N.1    Gaipa, G.2    Schumich, A.3
  • 43
    • 61849173968 scopus 로고    scopus 로고
    • CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: Setting the stage for anti-CD20 directed immunotherapy
    • 18780832 10.1182/blood-2008-06-164129 1:CAS:528:DC%2BD1cXhsVSmsrzE
    • Dworzak MN, Schumich A, Printz D, et al. CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy. Blood. 2008;112:3982-8.
    • (2008) Blood , vol.112 , pp. 3982-3988
    • Dworzak, M.N.1    Schumich, A.2    Printz, D.3
  • 44
    • 79957473019 scopus 로고    scopus 로고
    • CD20 up-regulation in induction therapy for childhood B lymphoblastic leukemia
    • 10.1182/blood-2010-02-261891
    • Watt TC, Park S, Cooper T. CD20 up-regulation in induction therapy for childhood B lymphoblastic leukemia. Blood. 2010;116:878-8.
    • (2010) Blood , vol.116 , pp. 878-888
    • Watt, T.C.1    Park, S.2    Cooper, T.3
  • 46
    • 78650823247 scopus 로고    scopus 로고
    • Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): A phase 3, randomised controlled trial
    • 21176949 10.1016/S0140-6736(10)62175-7 1:CAS:528:DC%2BC3MXms1Wq
    • Salles G, Seymour JF, Offner F, et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet. 2011;377:42-51.
    • (2011) Lancet , vol.377 , pp. 42-51
    • Salles, G.1    Seymour, J.F.2    Offner, F.3
  • 47
    • 83255176958 scopus 로고    scopus 로고
    • Rituximab maintenance for the treatment of patients with follicular lymphoma: An updated systematic review and meta-analysis of randomized trials
    • 22021664 10.1093/jnci/djr418 1:CAS:528:DC%2BC3MXhs1agtrbP
    • Vidal L, Gafter-Gvili A, Salles G, et al. Rituximab maintenance for the treatment of patients with follicular lymphoma: an updated systematic review and meta-analysis of randomized trials. J Natl Cancer Inst. 2011;103:1799-806.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1799-1806
    • Vidal, L.1    Gafter-Gvili, A.2    Salles, G.3
  • 50
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • 16785532 1:CAS:528:DC%2BD28XlvV2nt74%3D
    • Teeling JL, Mackus WJ, Wiegman LJ, et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol. 2006;177:362-71.
    • (2006) J Immunol , vol.177 , pp. 362-371
    • Teeling, J.L.1    MacKus, W.J.2    Wiegman, L.J.3
  • 51
    • 73949084380 scopus 로고    scopus 로고
    • Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
    • 19828699 10.1182/blood-2009-06-225474 1:CAS:528:DC%2BD1MXhsF2gsb%2FO
    • Li B, Zhao L, Guo H, et al. Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma. Blood. 2009;114:5007-15.
    • (2009) Blood , vol.114 , pp. 5007-5015
    • Li, B.1    Zhao, L.2    Guo, H.3
  • 52
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • 15172969 10.1182/blood-2004-01-0039 1:CAS:528:DC%2BD2cXns1Oktbc%3D
    • Teeling JL, French RR, Cragg MS, et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood. 2004;104:1793-800.
    • (2004) Blood , vol.104 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3
  • 53
    • 12444270688 scopus 로고    scopus 로고
    • Epratuzumab, a humanized monoclonal antibody targeting CD22: Characterization of in vitro properties
    • 14506197 1:CAS:528:DC%2BD3sXosVOksbc%3D
    • Carnahan J, Wang P, Kendall R, et al. Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties. Clin Cancer Res. 2003;9:3982S-90S.
    • (2003) Clin Cancer Res , vol.9
    • Carnahan, J.1    Wang, P.2    Kendall, R.3
  • 54
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
    • 16814387 10.1016/j.molimm.2006.05.007 1:CAS:528:DC%2BD28XpvVOgtr4%3D
    • Carnahan J, Stein R, Qu Z, et al. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol Immunol. 2007;44:1331-41.
    • (2007) Mol Immunol , vol.44 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3
  • 56
    • 49249109608 scopus 로고    scopus 로고
    • Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: A Children's Oncology Group Pilot Study
    • 10.1200/JCO.2007.15.3528 1:CAS:528:DC%2BD1cXhtVGjs7rP
    • Raetz EA, Cairo MS, Borowitz MJ, et al. Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: a Children's Oncology Group Pilot Study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2008;26:3756-62.
    • (2008) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.26 , pp. 3756-3762
    • Raetz, E.A.1    Cairo, M.S.2    Borowitz, M.J.3
  • 57
    • 84859159818 scopus 로고    scopus 로고
    • Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: Results from Children's Oncology Group (COG) Study ADVL04P2
    • Raetz EA, Cairo MS, Borowitz MJ, et al. Reinduction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL) in children, adolescents and young adults: Results from Children's Oncology Group (COG) Study ADVL04P2. Blood. 2011;118:264-4.
    • (2011) Blood , vol.118 , pp. 264-274
    • Raetz, E.A.1    Cairo, M.S.2    Borowitz, M.J.3
  • 58
    • 0028964750 scopus 로고
    • Primary structure of CD52
    • 7890742 10.1074/jbc.270.11.6088 1:CAS:528:DyaK2MXksVCntbs%3D
    • Treumann A, Lifely MR, Schneider P, et al. Primary structure of CD52. J Biol Chem. 1995;270:6088-99.
    • (1995) J Biol Chem , vol.270 , pp. 6088-6099
    • Treumann, A.1    Lifely, M.R.2    Schneider, P.3
  • 59
    • 0027240401 scopus 로고
    • Effect of Campath-1H antibody on human hematopoietic progenitors in vitro
    • 7687895 1:CAS:528:DyaK3sXmtVWnsb0%3D
    • Gilleece MH, Dexter TM. Effect of Campath-1H antibody on human hematopoietic progenitors in vitro. Blood. 1993;82:807-12.
    • (1993) Blood , vol.82 , pp. 807-812
    • Gilleece, M.H.1    Dexter, T.M.2
  • 60
    • 0023009274 scopus 로고
    • Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation
    • 3539172 10.1111/j.1365-2141.1986.tb02203.x 1:STN:280: DyaL2s%2Fns1CjtQ%3D%3D
    • Heit W, Bunjes D, Wiesneth M, et al. Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation. British journal of haematology. 1986;64:479-86.
    • (1986) British Journal of Haematology , vol.64 , pp. 479-486
    • Heit, W.1    Bunjes, D.2    Wiesneth, M.3
  • 61
    • 0024566393 scopus 로고
    • Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • 2713487 1:STN:280:DyaL1M3ivFeltA%3D%3D
    • Dyer MJ, Hale G, Hayhoe FG, et al. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype. Blood. 1989;73:1431-9.
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1    Hale, G.2    Hayhoe, F.G.3
  • 62
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells
    • 9824507 10.1046/j.1365-2567.1998.00615.x 1:CAS:528:DyaK1cXnsVyhtrw%3D
    • Rowan W, Tite J, Topley P, et al. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells. Immunology. 1998;95:427-36.
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3
  • 64
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • 11986207 10.1182/blood.V99.10.3554 1:CAS:528:DC%2BD38XjvVGns7o%3D
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 2002;99:3554-61.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 65
    • 33745190097 scopus 로고    scopus 로고
    • Activity of alemtuzumab in patients with CD52-positive acute leukemia
    • 16688777 10.1002/cncr.21901 1:CAS:528:DC%2BD28Xms1Sit78%3D
    • Tibes R, Keating MJ, Ferrajoli A, et al. Activity of alemtuzumab in patients with CD52-positive acute leukemia. Cancer. 2006;106:2645-51.
    • (2006) Cancer , vol.106 , pp. 2645-2651
    • Tibes, R.1    Keating, M.J.2    Ferrajoli, A.3
  • 66
    • 71049160105 scopus 로고    scopus 로고
    • A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: A Children's Oncology Group report
    • 19637330 10.1002/pbc.22209
    • Angiolillo AL, Yu AL, Reaman G, et al. A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report. Pediatr Blood Cancer. 2009;53:978-83.
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 978-983
    • Angiolillo, A.L.1    Yu, A.L.2    Reaman, G.3
  • 67
    • 79951816232 scopus 로고    scopus 로고
    • Alemtuzumab can be incorporated into front-line therapy of adult acute lymphoblastic leukemia (ALL): Final phase i results of a Cancer and Leukemia Group B study (CALGB 10102)
    • Stock W, Sanford B, Lozanski G, et al. Alemtuzumab can be incorporated into front-line therapy of adult acute lymphoblastic leukemia (ALL): Final phase I results of a Cancer and Leukemia Group B study (CALGB 10102). Blood. 2009;114:345-5.
    • (2009) Blood , vol.114 , pp. 345-355
    • Stock, W.1    Sanford, B.2    Lozanski, G.3
  • 68
    • 37149045571 scopus 로고    scopus 로고
    • CD52 over-expression affects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: Preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma
    • 18067019 10.1080/10428190701647879 1:CAS:528:DC%2BD2sXhsVShtLrP
    • Cruz RI, Hernandez-Ilizaliturri FJ, Olejniczak S, et al. CD52 over-expression affects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma. Leuk Lymphoma. 2007;48:2424-36.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2424-2436
    • Cruz, R.I.1    Hernandez-Ilizaliturri, F.J.2    Olejniczak, S.3
  • 69
    • 80054113954 scopus 로고    scopus 로고
    • Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
    • 22003069 10.1158/1078-0432.CCR-11-0486 1:CAS:528:DC%2BC3MXhtlSksrzF
    • Ricart AD. Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res. 2011;17:6417-27.
    • (2011) Clin Cancer Res , vol.17 , pp. 6417-6427
    • Ricart, A.D.1
  • 70
    • 79955806282 scopus 로고    scopus 로고
    • Inotuzumab Ozogamicin (CMC-544) in patients with indolent B-cell NHL that is refractory to rituximab alone, rituximab and chemotherapy, or radioimmunotherapy: Preliminary safety and efficacy from a phase 2 trial
    • Goy A, Leach J, Ehmann C, et al. Inotuzumab Ozogamicin (CMC-544) in patients with indolent B-cell NHL that is refractory to rituximab alone, rituximab and chemotherapy, or radioimmunotherapy: preliminary safety and efficacy from a phase 2 trial. Blood. 2010;116:192-3.
    • (2010) Blood , vol.116 , pp. 192-193
    • Goy, A.1    Leach, J.2    Ehmann, C.3
  • 71
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a phase i study
    • 10.1200/JCO.2009.25.1900 1:CAS:528:DC%2BC3cXmtlSks78%3D
    • Advani A, Coiffier B, Czuczman MS, et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28:2085-93.
    • (2010) Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology , vol.28 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.S.3
  • 72
    • 67650873888 scopus 로고    scopus 로고
    • Safety and clinical activity of the anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) in combination with rituximab in follicular lymphoma or diffuse large B-Cell lymphoma: Preliminary report of a phase 1/2 study
    • Fayad L, Patel H, Verhoef G, et al. Safety and clinical activity of the anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) in combination with rituximab in follicular lymphoma or diffuse large B-Cell lymphoma: Preliminary report of a phase 1/2 study. Blood. 2008;112:105-5.
    • (2008) Blood , vol.112 , pp. 105-115
    • Fayad, L.1    Patel, H.2    Verhoef, G.3
  • 73
    • 84862786326 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: A phase 2 study
    • 22357140 10.1016/S1470-2045(11)70386-2 1:CAS:528:DC%2BC38XkvV2qsr4%3D Article highlighting the efficacy of novel anti-CD22 antibody Inotuzumab ozogamicin in patients with relapsed/refractory B-cell ALL
    • •• Kantarjian H, Thomas D, Jorgensen J, et al. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. Lancet Oncol. 2012;13:403-11. Article highlighting the efficacy of novel anti-CD22 antibody Inotuzumab ozogamicin in patients with relapsed/refractory B-cell ALL.
    • (2012) Lancet Oncol , vol.13 , pp. 403-411
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3
  • 74
    • 80054095609 scopus 로고    scopus 로고
    • SAR3419: An anti-CD19-Maytansinoid immunoconjugate for the treatment of B-cell malignancies
    • 22003072 10.1158/1078-0432.CCR-11-0485 1:CAS:528:DC%2BC3MXhtlSksr3O
    • Blanc V, Bousseau A, Caron A, et al. SAR3419: an anti-CD19-Maytansinoid immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res. 2011;17:6448-58.
    • (2011) Clin Cancer Res , vol.17 , pp. 6448-6458
    • Blanc, V.1    Bousseau, A.2    Caron, A.3
  • 75
    • 67449158986 scopus 로고    scopus 로고
    • Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma
    • 19509168 10.1158/1078-0432.CCR-08-2808 1:CAS:528:DC%2BD1MXntlOis7c%3D
    • Al-Katib AM, Aboukameel A, Mohammad R, et al. Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma. Clin Cancer Res. 2009;15:4038-45.
    • (2009) Clin Cancer Res , vol.15 , pp. 4038-4045
    • Al-Katib, A.M.1    Aboukameel, A.2    Mohammad, R.3
  • 76
    • 78650279693 scopus 로고    scopus 로고
    • Phase i multi-dose escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous (IV) Infusion every 3 weeks to patients with relapsed refractory B-Cell non-hodgkin's lymphoma (NHL)
    • Younes A, Gordon L, Kim S, et al. Phase I multi-dose escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous (IV) Infusion every 3 weeks to patients with relapsed refractory B-Cell non-hodgkin's lymphoma (NHL). Blood. 2009;114:243-3.
    • (2009) Blood , vol.114 , pp. 243-253
    • Younes, A.1    Gordon, L.2    Kim, S.3
  • 77
    • 78650286160 scopus 로고    scopus 로고
    • Investigational antibody-drug conjugates for hematological malignancies
    • 10.1517/13543784.2011.539557 1:CAS:528:DC%2BC3cXhsFOjsbrP
    • Polson AG, Ho WY, Ramakrishnan V. Investigational antibody-drug conjugates for hematological malignancies. Expert Opin Inv Drug. 2011;20:75-85.
    • (2011) Expert Opin Inv Drug , vol.20 , pp. 75-85
    • Polson, A.G.1    Ho, W.Y.2    Ramakrishnan, V.3
  • 78
    • 80054118081 scopus 로고    scopus 로고
    • Antibody fusion proteins: Anti-CD22 recombinant immunotoxin moxetumomab pasudotox
    • 22003067 10.1158/1078-0432.CCR-11-0487 1:CAS:528:DC%2BC3MXhtlSksrzL
    • Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clin Cancer Res. 2011;17:6398-405.
    • (2011) Clin Cancer Res , vol.17 , pp. 6398-6405
    • Kreitman, R.J.1    Pastan, I.2
  • 80
    • 0035954624 scopus 로고    scopus 로고
    • Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
    • 11474661 10.1056/NEJM200107263450402 1:CAS:528:DC%2BD3MXlvVKqs7k%3D
    • Kreitman RJ, Wilson WH, Bergeron K, et al. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med. 2001;345:241-7.
    • (2001) N Engl J Med , vol.345 , pp. 241-247
    • Kreitman, R.J.1    Wilson, W.H.2    Bergeron, K.3
  • 82
    • 77949679970 scopus 로고    scopus 로고
    • Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: Preclinical studies and phase i clinical trial
    • 20215554 10.1158/1078-0432.CCR-09-2980 1:CAS:528:DC%2BC3cXjtFyhuro%3D
    • Wayne AS, Kreitman RJ, Findley HW, et al. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. Clin Cancer Res. 2010;16:1894-903.
    • (2010) Clin Cancer Res , vol.16 , pp. 1894-1903
    • Wayne, A.S.1    Kreitman, R.J.2    Findley, H.W.3
  • 83
    • 0036554968 scopus 로고    scopus 로고
    • Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display
    • 11948105 1:CAS:528:DC%2BD38XjsF2lsbo%3D
    • Salvatore G, Beers R, Margulies I, et al. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Clin Cancer Res. 2002;8:995-1002.
    • (2002) Clin Cancer Res , vol.8 , pp. 995-1002
    • Salvatore, G.1    Beers, R.2    Margulies, I.3
  • 84
    • 80051743261 scopus 로고    scopus 로고
    • A phase 1 study of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in relapsed/refractory hairy cell leukemia (HCL): Updated results
    • Kreitman RJ, Tallman MS, Coutre S, et al. A phase 1 study of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in relapsed/refractory hairy cell leukemia (HCL): Updated results. Blood. 2010;116:1042-3.
    • (2010) Blood , vol.116 , pp. 1042-1043
    • Kreitman, R.J.1    Tallman, M.S.2    Coutre, S.3
  • 85
    • 84859156821 scopus 로고    scopus 로고
    • A novel anti-CD22 immunotoxin, moxetumomab pasudotox: Phase i study in pediatric acute lymphoblastic leukemia (ALL)
    • One of the first phase II studies to evaluate the efficacy and tolerability of conjugated immunotoxons in B-cell ALL
    • • Wayne AS, Bhojwani D, Silverman LB, et al. A novel anti-CD22 immunotoxin, moxetumomab pasudotox: Phase I study in pediatric acute lymphoblastic leukemia (ALL). Blood. 2011;118:113-3. One of the first phase II studies to evaluate the efficacy and tolerability of conjugated immunotoxons in B-cell ALL.
    • (2011) Blood , vol.118 , pp. 113-123
    • Wayne, A.S.1    Bhojwani, D.2    Silverman, L.B.3
  • 86
    • 65549146468 scopus 로고    scopus 로고
    • A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
    • 18988862 10.1182/blood-2008-08-173195 1:CAS:528:DC%2BD1MXlt1yjsb8%3D
    • Weldon JE, Xiang L, Chertov O, et al. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 2009;113:3792-800.
    • (2009) Blood , vol.113 , pp. 3792-3800
    • Weldon, J.E.1    Xiang, L.2    Chertov, O.3
  • 87
    • 79955007493 scopus 로고    scopus 로고
    • Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes
    • 21436054 10.1073/pnas.1102746108 1:CAS:528:DC%2BC3MXkvVChtr4%3D
    • Onda M, Beers R, Xiang LM, et al. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:5742-7.
    • (2011) Proceedings of the National Academy of Sciences of the United States of America , vol.108 , pp. 5742-5747
    • Onda, M.1    Beers, R.2    Xiang, L.M.3
  • 88
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • 18703743 10.1126/science.1158545 1:CAS:528:DC%2BD1cXpslWru70%3D
    • Bargou R, Leo E, Zugmaier G, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321:974-7.
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3
  • 89
    • 78651295592 scopus 로고    scopus 로고
    • Blinatumomab (anti-Cd19 Bite?) for targeted therapy of minimal residual disease (Mrd) in Patients with B precursor acute lymphoblastic leukemia (All): Update of an ongoing Phase II study
    • 10.3324/haematol.13422
    • Topp MS, Goekbuget N, Kufer P, et al. Blinatumomab (anti-Cd19 Bite?) for targeted therapy of minimal residual disease (Mrd) in Patients with B precursor acute lymphoblastic leukemia (All): Update of an ongoing Phase II study. Haematol-Hematol J. 2009;94:195-5.
    • (2009) Haematol-Hematol J , vol.94 , pp. 195-205
    • Topp, M.S.1    Goekbuget, N.2    Kufer, P.3
  • 90
    • 84878749293 scopus 로고    scopus 로고
    • Long-term follow-up of hematological relapse-free survival in a phase 2 study of blinatumomab in patients with minimal residual disease (MRD) of B-precursor acute lymphoblastic leukemia (ALL)
    • ;Epub 2012/10/02: ISSN 1528-0020 (Electronic)
    • Topp MS, Gokbuget N, Zugmaier G, et al.: Long-term follow-up of hematological relapse-free survival in a phase 2 study of blinatumomab in patients with minimal residual disease (MRD) of B-precursor acute lymphoblastic leukemia (ALL). Blood. 2012;Epub 2012/10/02: ISSN 1528-0020 (Electronic)
    • (2012) Blood
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3
  • 91
    • 78651290248 scopus 로고    scopus 로고
    • Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
    • 10.1038/leu.2010.239 1:STN:280:DC%2BC3M7gsVKisw%3D%3D
    • Handgretinger R, Zugmaier G, Henze G, et al. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK. 2011;25:181-4.
    • (2011) Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK , vol.25 , pp. 181-184
    • Handgretinger, R.1    Zugmaier, G.2    Henze, G.3
  • 92
    • 84856994479 scopus 로고    scopus 로고
    • Anti-CD19 BITE Blinatumomab induces high complete remission rate in adult patients with relapsed B-precursor ALL: Updated results of an ongoing phase II trial
    • Topp MS, Goekbuget N, Zugmaier G, et al. Anti-CD19 BITE Blinatumomab induces high complete remission rate In adult patients with relapsed B-precursor ALL: Updated results of an ongoing phase II trial. Blood. 2011;118:115-5.
    • (2011) Blood , vol.118 , pp. 115-125
    • Topp, M.S.1    Goekbuget, N.2    Zugmaier, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.