메뉴 건너뛰기




Volumn 18, Issue 7, 2013, Pages 836-850

Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents

Author keywords

Akt; Apoptosis; Cyclooxygenase 2; Erythroleukemia; PTEN

Indexed keywords

ANTINEOPLASTIC AGENT; CASEIN KINASE II; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

EID: 84878743076     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0825-7     Document Type: Article
Times cited : (10)

References (56)
  • 1
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases: Structural, cellular, and molecular biology
    • 10966456 10.1146/annurev.biochem.69.1.145 1:CAS:528:DC%2BD3cXnt1ajtLg%3D
    • Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145-182
    • (2000) Annu Rev Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    Dewitt, D.L.2    Garavito, R.M.3
  • 2
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • 20168319 10.1038/nrc2809 1:CAS:528:DC%2BC3cXitFemsbs%3D
    • Wang D, Dubois RN (2010) Eicosanoids and cancer. Nat Rev Cancer 10:181-193
    • (2010) Nat Rev Cancer , vol.10 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 3
    • 0036157485 scopus 로고    scopus 로고
    • Many actions of cyclooxygenase-2 in cellular dynamics and in cancer
    • 11857443 10.1002/jcp.10068 1:CAS:528:DC%2BD38XhtV2hu7g%3D
    • Cao Y, Prescott SM (2002) Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 190:279-286
    • (2002) J Cell Physiol , vol.190 , pp. 279-286
    • Cao, Y.1    Prescott, S.M.2
  • 4
    • 4544327894 scopus 로고    scopus 로고
    • Cyclooxygenases in cancer: Progress and perspective
    • 15374627 10.1016/j.canlet.2004.06.014 1:CAS:528:DC%2BD2cXnslGhsr0%3D
    • Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM (2004) Cyclooxygenases in cancer: progress and perspective. Cancer Lett 215:1-20
    • (2004) Cancer Lett , vol.215 , pp. 1-20
    • Zha, S.1    Yegnasubramanian, V.2    Nelson, W.G.3    Isaacs, W.B.4    De Marzo, A.M.5
  • 5
    • 0037307483 scopus 로고    scopus 로고
    • Cyclooxygenase 2: A molecular target for cancer prevention and treatment
    • 12559775 10.1016/S0165-6147(02)00043-3 1:CAS:528:DC%2BD3sXmt1aktA%3D%3D
    • Subbaramaiah K, Dannenberg AJ (2003) Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 24:96-102
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 96-102
    • Subbaramaiah, K.1    Dannenberg, A.J.2
  • 6
    • 52949102543 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in hematological malignancies: Rationale and promise
    • 18691115 10.2174/138161208785294654 1:CAS:528:DC%2BD1cXhtFans77N
    • Bernard MP, Bancos S, Sime PJ, Phipps RP (2008) Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des 14:2051-2060
    • (2008) Curr Pharm des , vol.14 , pp. 2051-2060
    • Bernard, M.P.1    Bancos, S.2    Sime, P.J.3    Phipps, R.P.4
  • 7
    • 73949133917 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway
    • 19825968 10.1093/carcin/bgp244 1:CAS:528:DC%2BD1MXhsFGhurrN
    • Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML (2009) Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis 30:2005-2013
    • (2009) Carcinogenesis , vol.30 , pp. 2005-2013
    • Chien, M.H.1    Ku, C.C.2    Johansson, G.3    Chen, M.W.4    Hsiao, M.5    Su, J.L.6    Inoue, H.7    Hua, K.T.8    Wei, L.H.9    Kuo, M.L.10
  • 8
    • 81255176271 scopus 로고    scopus 로고
    • Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population
    • 21848701 10.1111/j.1600-0609.2011.01691.x 1:CAS:528: DC%2BC38XmsFyjuw%3D%3D
    • Zheng J, Chen S, Jiang L, You Y, Wu D, Zhou Y (2011) Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Eur J Haematol 87:486-493
    • (2011) Eur J Haematol , vol.87 , pp. 486-493
    • Zheng, J.1    Chen, S.2    Jiang, L.3    You, Y.4    Wu, D.5    Zhou, Y.6
  • 9
    • 78649515416 scopus 로고    scopus 로고
    • Acute erythroleukemia: Diagnosis and management
    • 21091147 10.1586/ehm.10.62
    • Santos FP, Bueso-Ramos CE, Ravandi F (2010) Acute erythroleukemia: diagnosis and management. Expert Rev Hematol 3:705-718
    • (2010) Expert Rev Hematol , vol.3 , pp. 705-718
    • Santos, F.P.1    Bueso-Ramos, C.E.2    Ravandi, F.3
  • 10
    • 0034891563 scopus 로고    scopus 로고
    • Inhibitors of cyclooxygenase-2 (COX-2) suppressed the proliferation and differentiation of human leukaemia cell lines
    • 11506967 10.1016/S0959-8049(01)00160-5 1:CAS:528:DC%2BD3MXlvFWitbo%3D
    • Nakanishi Y, Kamijo R, Takizawa K, Hatori M, Nagumo M (2001) Inhibitors of cyclooxygenase-2 (COX-2) suppressed the proliferation and differentiation of human leukaemia cell lines. Eur J Cancer 37:1570-1578
    • (2001) Eur J Cancer , vol.37 , pp. 1570-1578
    • Nakanishi, Y.1    Kamijo, R.2    Takizawa, K.3    Hatori, M.4    Nagumo, M.5
  • 11
    • 19344375948 scopus 로고    scopus 로고
    • Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro
    • 15911099 10.1016/j.canlet.2004.11.002 1:CAS:528:DC%2BD2MXks1aktrY%3D
    • Subhashini J, Mahipal SV, Reddanna P (2005) Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. Cancer Lett 224:31-43
    • (2005) Cancer Lett , vol.224 , pp. 31-43
    • Subhashini, J.1    Mahipal, S.V.2    Reddanna, P.3
  • 12
    • 12244265088 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 reduces overt toxicity toward low-dose vinblastine and extends survival of juvenile mice with Friend disease
    • 15701860 1:CAS:528:DC%2BD2MXislWgur4%3D
    • Cervi D, Klement G, Stempak D, Baruchel S, Koki A, Ben-David Y (2005) Targeting cyclooxygenase-2 reduces overt toxicity toward low-dose vinblastine and extends survival of juvenile mice with Friend disease. Clin Cancer Res 11:712-719
    • (2005) Clin Cancer Res , vol.11 , pp. 712-719
    • Cervi, D.1    Klement, G.2    Stempak, D.3    Baruchel, S.4    Koki, A.5    Ben-David, Y.6
  • 13
    • 0035850836 scopus 로고    scopus 로고
    • A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells
    • 11602250 10.1016/S0014-5793(01)02924-6 1:CAS:528:DC%2BD3MXnsF2gu74%3D
    • Moalic S, Liagre B, Corbière C, Bianchi A, Dauça M, Bordji K, Beneytout JL (2001) A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett 506:225-230
    • (2001) FEBS Lett , vol.506 , pp. 225-230
    • Moalic, S.1    Liagre, B.2    Corbière, C.3    Bianchi, A.4    Dauça, M.5    Bordji, K.6    Beneytout, J.L.7
  • 14
    • 12844273499 scopus 로고    scopus 로고
    • Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression
    • 10.1186/ar1199
    • Liagre B, Vergne-Salle P, Corbiere C, Charissoux JL, Beneytout JL (2004) Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression. Arthritis Res Ther 6:373-383
    • (2004) Arthritis Res Ther , vol.6 , pp. 373-383
    • Liagre, B.1    Vergne-Salle, P.2    Corbiere, C.3    Charissoux, J.L.4    Beneytout, J.L.5
  • 15
    • 8844280276 scopus 로고    scopus 로고
    • Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells
    • 15225412 10.1038/sj.cr.7290219 1:CAS:528:DC%2BD2cXmt1CgsLs%3D
    • Corbiere C, Liagre B, Terro F, Beneytout JL (2004) Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Res 14:188-196
    • (2004) Cell Res , vol.14 , pp. 188-196
    • Corbiere, C.1    Liagre, B.2    Terro, F.3    Beneytout, J.L.4
  • 16
    • 8844274306 scopus 로고    scopus 로고
    • Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression
    • 15289856 1:CAS:528:DC%2BD2cXnt1Ohurc%3D
    • Leger DY, Liagre B, Corbiere C, Cook-Moreau J, Beneytout JL (2004) Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression. Int J Oncol 25:555-562
    • (2004) Int J Oncol , vol.25 , pp. 555-562
    • Leger, D.Y.1    Liagre, B.2    Corbiere, C.3    Cook-Moreau, J.4    Beneytout, J.L.5
  • 17
    • 33644878740 scopus 로고    scopus 로고
    • Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding
    • 16273292 1:CAS:528:DC%2BD2MXhtlWrt7zJ
    • Liagre B, Bertrand J, Leger DY, Beneytout JL (2005) Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding. Int J Mol Med 16:1095-1101
    • (2005) Int J Mol Med , vol.16 , pp. 1095-1101
    • Liagre, B.1    Bertrand, J.2    Leger, D.Y.3    Beneytout, J.L.4
  • 18
    • 46849084316 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells
    • 18549804 10.1016/j.ab.2008.05.026 1:CAS:528:DC%2BD1cXosVymsrg%3D
    • Cailleteau C, Liagre B, Battu S, Jayat-Vignoles C, Beneytout JL (2008) Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells. Anal Biochem 380:26-34
    • (2008) Anal Biochem , vol.380 , pp. 26-34
    • Cailleteau, C.1    Liagre, B.2    Battu, S.3    Jayat-Vignoles, C.4    Beneytout, J.L.5
  • 19
    • 67650067290 scopus 로고    scopus 로고
    • Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells
    • 19384950 10.1002/ijc.24419 1:CAS:528:DC%2BD1MXnsFeltbs%3D
    • Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C (2009) Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer 125:961-967
    • (2009) Int J Cancer , vol.125 , pp. 961-967
    • Srinivasan, S.1    Koduru, S.2    Kumar, R.3    Venguswamy, G.4    Kyprianou, N.5    Damodaran, C.6
  • 20
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • 10866658 10.1128/MCB.20.14.5010-5018.2000 1:CAS:528:DC%2BD3cXks1Ojsr8%3D
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20:5010-5018
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 21
    • 78650984175 scopus 로고    scopus 로고
    • Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity
    • 20854947 10.1016/j.bone.2010.09.020 1:CAS:528:DC%2BC3MXmvF2lsA%3D%3D
    • Li CJ, Chang JK, Wang GJ, Ho ML (2011) Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity. Bone 48:286-297
    • (2011) Bone , vol.48 , pp. 286-297
    • Li, C.J.1    Chang, J.K.2    Wang, G.J.3    Ho, M.L.4
  • 22
    • 79955952869 scopus 로고    scopus 로고
    • Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival
    • 21592330 10.1186/1471-2490-11-8 1:CAS:528:DC%2BC3MXmvVKkurs%3D
    • Shimada K, Anai S, Marco DA, Fujimoto K, Konishi N (2011) Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival. BMC Urol 11:8
    • (2011) BMC Urol , vol.11 , pp. 8
    • Shimada, K.1    Anai, S.2    Marco, D.A.3    Fujimoto, K.4    Konishi, N.5
  • 23
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • 8521479 10.1016/0092-8674(95)90127-2 1:CAS:528:DyaK2MXpt1Olt7w%3D
    • Tsujii M, DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    Dubois, R.N.2
  • 25
    • 33749612562 scopus 로고    scopus 로고
    • What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    • 16921484 10.1002/ijc.22153
    • Fürstenberger G, Krieg P, Müller-Decker K, Habenicht AJ (2006) What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? Int J Cancer 119:2247-2254
    • (2006) Int J Cancer , vol.119 , pp. 2247-2254
    • Fürstenberger, G.1    Krieg, P.2    Müller-Decker, K.3    Habenicht, A.J.4
  • 26
    • 33745181682 scopus 로고    scopus 로고
    • Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells
    • 16473553 10.1016/j.clim.2005.12.012 1:CAS:528:DC%2BD28XlvF2lurk%3D
    • Ryan EP, Pollock SJ, Kaur K, Felgar RE, Bernstein SH, Chiorazzi N, Phipps RP (2006) Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. Clin Immunol 120:76-90
    • (2006) Clin Immunol , vol.120 , pp. 76-90
    • Ryan, E.P.1    Pollock, S.J.2    Kaur, K.3    Felgar, R.E.4    Bernstein, S.H.5    Chiorazzi, N.6    Phipps, R.P.7
  • 27
    • 4043124898 scopus 로고    scopus 로고
    • Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells
    • 15298963 1:CAS:528:DC%2BD2cXmtleks7w%3D
    • Raju J, Patlolla JM, Swamy MV, Rao CV (2004) Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev 13:1392-1398
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1392-1398
    • Raju, J.1    Patlolla, J.M.2    Swamy, M.V.3    Rao, C.V.4
  • 28
    • 34547945104 scopus 로고    scopus 로고
    • Diosgenin, a naturally occurring steroid saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells
    • 17555873 10.1016/j.canlet.2007.04.011 1:CAS:528:DC%2BD2sXpsFKqurc%3D
    • Raju J, Bird RP (2007) Diosgenin, a naturally occurring steroid saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Lett 255:194-204
    • (2007) Cancer Lett , vol.255 , pp. 194-204
    • Raju, J.1    Bird, R.P.2
  • 29
    • 77951908366 scopus 로고    scopus 로고
    • Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
    • 20053498 10.1016/j.canlet.2009.12.003 1:CAS:528:DC%2BC3cXkvFemtrg%3D
    • Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G (2010) Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett 292:197-207
    • (2010) Cancer Lett , vol.292 , pp. 197-207
    • Li, F.1    Fernandez, P.P.2    Rajendran, P.3    Hui, K.M.4    Sethi, G.5
  • 30
    • 78651461704 scopus 로고    scopus 로고
    • Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells
    • 21195543 10.1016/j.canlet.2010.12.003 1:CAS:528:DC%2BC3MXmsVGhtg%3D%3D
    • Lepage C, Léger DY, Bertrand J, Martin F, Beneytout JL, Liagre B (2011) Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett 301:193-202
    • (2011) Cancer Lett , vol.301 , pp. 193-202
    • Lepage, C.1    Léger, D.Y.2    Bertrand, J.3    Martin, F.4    Beneytout, J.L.5    Liagre, B.6
  • 31
    • 33644840279 scopus 로고    scopus 로고
    • Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, i kappa B kinase activation and NF-kappa B-regulated gene expression
    • 16331273 10.1038/sj.onc.1209194 1:CAS:528:DC%2BD28XitFGht78%3D
    • Shishodia S, Aggarwal BB (2006) Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene 25:1463-1473
    • (2006) Oncogene , vol.25 , pp. 1463-1473
    • Shishodia, S.1    Aggarwal, B.B.2
  • 32
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • 10579998 10.1101/gad.13.22.2905 1:CAS:528:DyaK1MXnvVCltLo%3D
    • Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13:2905-2927
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 33
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • 15505410 10.1023/B:APPT.0000045801.15585.dd 1:CAS:528: DC%2BD2cXovVKqu70%3D
    • Osaki M, Oshimura M, Ito H (2004) PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9:667-676
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 34
    • 7044270928 scopus 로고    scopus 로고
    • Putting the rap on Akt
    • 15483033 10.1200/JCO.2004.01.103 1:CAS:528:DC%2BD2cXpslOrsLs%3D
    • Thompson JE, Thompson CB (2004) Putting the rap on Akt. J Clin Oncol 22:4217-4226
    • (2004) J Clin Oncol , vol.22 , pp. 4217-4226
    • Thompson, J.E.1    Thompson, C.B.2
  • 35
    • 34548642127 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: From bench to bedside
    • 17691943 10.2174/092986707781368423 1:CAS:528:DC%2BD2sXosFequ7w%3D
    • Martelli AM, Tazzari PL, Evangelisti C, Chiarini F, Blalock WL, Billi AM, Manzoli L, McCubrey JA, Cocco L (2007) Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside. Curr Med Chem 14:2009-2023
    • (2007) Curr Med Chem , vol.14 , pp. 2009-2023
    • Martelli, A.M.1    Tazzari, P.L.2    Evangelisti, C.3    Chiarini, F.4    Blalock, W.L.5    Billi, A.M.6    Manzoli, L.7    McCubrey, J.A.8    Cocco, L.9
  • 36
    • 44149095198 scopus 로고    scopus 로고
    • Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
    • 18454317 10.1007/s10495-008-0212-y 1:CAS:528:DC%2BD1cXlvFais70%3D
    • Johnson GE, Ivanov VN, Hei TK (2008) Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. Apoptosis 13:790-802
    • (2008) Apoptosis , vol.13 , pp. 790-802
    • Johnson, G.E.1    Ivanov, V.N.2    Hei, T.K.3
  • 37
    • 15944394073 scopus 로고    scopus 로고
    • Rapamycin and UCN-01 synergistically induced apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways
    • 15767555 1:CAS:528:DC%2BD2MXit1Knsrk%3D
    • Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S (2005) Rapamycin and UCN-01 synergistically induced apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Mol Cancer Ther 4:457-470
    • (2005) Mol Cancer Ther , vol.4 , pp. 457-470
    • Hahn, M.1    Li, W.2    Yu, C.3    Rahmani, M.4    Dent, P.5    Grant, S.6
  • 39
    • 16544385074 scopus 로고    scopus 로고
    • Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: Final induction results of Cancer and Leukemia Group B Study 9,621
    • 15514371 10.1200/JCO.2004.11.106 1:CAS:528:DC%2BD2cXhtVKju7fN
    • Kolitz JE, George SL, Dodge RK et al (2004) Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B Study 9,621. J Clin Oncol 22:4290-4301
    • (2004) J Clin Oncol , vol.22 , pp. 4290-4301
    • Kolitz, J.E.1    George, S.L.2    Dodge, R.K.3
  • 40
    • 69849092737 scopus 로고    scopus 로고
    • A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
    • 19470696 10.1182/blood-2009-01-198093 1:CAS:528:DC%2BD1MXhtVSgsbfN
    • Harousseau JL, Martinelli G, Jedrzejczak WW et al (2009) A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood 114:1166-1173
    • (2009) Blood , vol.114 , pp. 1166-1173
    • Harousseau, J.L.1    Martinelli, G.2    Jedrzejczak, W.W.3
  • 41
    • 80053025527 scopus 로고    scopus 로고
    • Development of 5-fluorouracil derivatives as anticancer agents
    • 21864282 10.2174/092986711797287584 1:CAS:528:DC%2BC3MXhtlOktLrF
    • Pan X, Wang C, Wang F, Li P, Hu Z, Shan Y, Zhang J (2011) Development of 5-fluorouracil derivatives as anticancer agents. Curr Med Chem 18:4538-4556
    • (2011) Curr Med Chem , vol.18 , pp. 4538-4556
    • Pan, X.1    Wang, C.2    Wang, F.3    Li, P.4    Hu, Z.5    Shan, Y.6    Zhang, J.7
  • 42
    • 33748547765 scopus 로고    scopus 로고
    • Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents
    • 16927021 10.1007/s10495-006-9439-7 1:CAS:528:DC%2BD28XptF2rurc%3D
    • Leger DY, Liagre B, Beneytout JL (2006) Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents. Apoptosis 11:1747-1760
    • (2006) Apoptosis , vol.11 , pp. 1747-1760
    • Leger, D.Y.1    Liagre, B.2    Beneytout, J.L.3
  • 43
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
    • 15703783 1:CAS:528:DC%2BD2MXjs1Olur4%3D
    • Grandage VL, Gale RE, Linch DC, Khwaja A (2005) PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 19:586-594
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 44
    • 70349826431 scopus 로고    scopus 로고
    • Understanding the causes of multidrug resistance in cancer: A comparison of doxorubicin and sunitinib
    • 19648052 10.1016/j.drup.2009.07.001 1:CAS:528:DC%2BD1MXht1OgtbvM
    • Broxterman HJ, Gotink KJ, Verheul HM (2009) Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Updat 12:114-126
    • (2009) Drug Resist Updat , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 45
    • 19344374597 scopus 로고    scopus 로고
    • Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
    • 15705789 10.1182/blood-2004-09-3706 1:CAS:528:DC%2BD2MXks12isb8%3D
    • Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB (2005) Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood 105:4477-4483
    • (2005) Blood , vol.105 , pp. 4477-4483
    • Hammerman, P.S.1    Fox, C.J.2    Birnbaum, M.J.3    Thompson, C.B.4
  • 47
    • 84856244294 scopus 로고    scopus 로고
    • The PI3K/PKB signaling module as key regulator of hematopoiesis: Implications for therapeutic strategies in leukemia
    • 22065598 10.1182/blood-2011-07-366203 1:CAS:528:DC%2BC38XitVKqt70%3D
    • Polak R, Buitenhuis M (2012) The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia. Blood 119:911-923
    • (2012) Blood , vol.119 , pp. 911-923
    • Polak, R.1    Buitenhuis, M.2
  • 48
    • 0035947586 scopus 로고    scopus 로고
    • Prostaglandin E2 increases growth and motility of colorectal carcinoma cells
    • 11278548 10.1074/jbc.M009689200 1:CAS:528:DC%2BD3MXktFWms7o%3D
    • Sheng H, Shao J, Washington MK, DuBois RN (2001) Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 276:18075-18081
    • (2001) J Biol Chem , vol.276 , pp. 18075-18081
    • Sheng, H.1    Shao, J.2    Washington, M.K.3    Dubois, R.N.4
  • 49
    • 85047690934 scopus 로고    scopus 로고
    • Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    • 15578100 1:CAS:528:DC%2BD2cXhtVKhurrM
    • Tessner TG, Muhale F, Riehl TE, Anant S, Stenson WF (2004) Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 114:1676-1685
    • (2004) J Clin Invest , vol.114 , pp. 1676-1685
    • Tessner, T.G.1    Muhale, F.2    Riehl, T.E.3    Anant, S.4    Stenson, W.F.5
  • 51
    • 34548159221 scopus 로고    scopus 로고
    • Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor
    • 17369849 10.1038/sj.onc.1210391 1:CAS:528:DC%2BD2sXpsVaqur0%3D
    • Covey TM, Edes K, Fitzpatrick FA (2007) Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. Oncogene 26:5784-5792
    • (2007) Oncogene , vol.26 , pp. 5784-5792
    • Covey, T.M.1    Edes, K.2    Fitzpatrick, F.A.3
  • 53
    • 39249084592 scopus 로고    scopus 로고
    • Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway
    • 18178094 10.1016/j.nbd.2007.11.010 1:CAS:528:DC%2BD1cXisVWnsL4%3D
    • Zhou P, Qian L, Chou T, Iadecola C (2008) Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway. Neurobiol Dis 29:543-551
    • (2008) Neurobiol Dis , vol.29 , pp. 543-551
    • Zhou, P.1    Qian, L.2    Chou, T.3    Iadecola, C.4
  • 54
    • 45549109399 scopus 로고    scopus 로고
    • Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells
    • 18319253 10.1074/jbc.M710038200 1:CAS:528:DC%2BD1cXkvVSgsL8%3D
    • Pan MR, Hou MF, Chang HC, Hung WC (2008) Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. J Biol Chem 283:11155-11163
    • (2008) J Biol Chem , vol.283 , pp. 11155-11163
    • Pan, M.R.1    Hou, M.F.2    Chang, H.C.3    Hung, W.C.4
  • 55
    • 67749099442 scopus 로고    scopus 로고
    • Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms
    • 19407222 10.1210/me.2009-0017 1:CAS:528:DC%2BD1MXpsFOnurk%3D
    • Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA (2009) Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. Mol Endocrinol 23:1291-1305
    • (2009) Mol Endocrinol , vol.23 , pp. 1291-1305
    • Banu, S.K.1    Lee, J.2    Speights, Jr.V.O.3    Starzinski-Powitz, A.4    Arosh, J.A.5
  • 56
    • 33846457039 scopus 로고    scopus 로고
    • EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway
    • 17259077 10.1016/j.prostaglandins.2006.10.005 1:CAS:528: DC%2BD2sXhtVejsr4%3D
    • George RJ, Sturmoski MA, Anant S, Houchen CW (2007) EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat 83:112-120
    • (2007) Prostaglandins Other Lipid Mediat , vol.83 , pp. 112-120
    • George, R.J.1    Sturmoski, M.A.2    Anant, S.3    Houchen, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.