The novel crohn's disease marker anti-GP2 antibody is associated with ileocolonic location of disease

Gastroenterology Research and Practice

Volumn 2013, Issue , 2013, Pages

  Somma, Valentina ^a   Ababneh, Hani ^b   Ababneh, Ahmad ^c   Gatti, Simona ^d   Romagnoli, Vittorio ^d   Bendia, Emanuele ^e   Conrad, Karsten ^f   Bogdanos, Dimitrios P ^g   Roggenbuck, Dirk ^a,h   Ciarrocchi, Gino ^e  

^a Medipan GmbH   (Germany)

^b KING HUSSEIN MEDICAL CENTER   (Jordan)

^c UNIVERSITY OF JORDAN   (Jordan)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e OSPEDALI RIUNITI   (Italy)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g KING S COLLEGE HOSPITAL   (United Kingdom)

^h Lausitz University of Applied Sciences   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BIOLOGICAL MARKER; ENZYME PRECURSOR; GLYCOPROTEIN; GLYCOPROTEIN 2; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

AUTOIMMUNITY; CROHN DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFLAMMATION; PANCREAS; PROTEIN EXPRESSION; REVIEW;

EID: 84878729263     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2013/683824     Document Type: Review

References (52)

1. Logan I., Bowlus C. L., The geoepidemiology of autoimmune intestinal diseases. Autoimmunity Reviews 2010 9 5 A372 A378 2-s2.0-77649233106 10.1016/j.autrev.2009.11.008
2. Shivananda S., Lennard-Jones J., Logan R., Fear N., Price A., Carpenter L., Van Blankenstein M., Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European collaborative study on inflammatory bowel disease (EC-IBD). Gut 1996 39 5 690 697 2-s2.0-0030451868 (Pubitemid 26426470)
3. Loftus E. V. Jr., Schoenfeld P., Sandborn W. J., The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review. Alimentary Pharmacology and Therapeutics 2002 16 1 51 60 2-s2.0-0036161786 10.1046/j.1365-2036.2002.01140.x (Pubitemid 34123864)
4. Bernstein C. N., Wajda A., Svenson L. W., MacKenzie A., Koehoorn M., Jackson M., Fedorak R., Israel D., Blanchard J. F., The epidemiology of inflammatory bowel disease in Canada: a population-based study. American Journal of Gastroenterology 2006 101 7 1559 1568 2-s2.0-33745541232 10.1111/j.1572-0241.2006.00603.x (Pubitemid 43980630)
5. Baumgart D. C., Sandborn W. J., Inflammatory bowel disease: clinical aspects and established and evolving therapies. The Lancet 2007 369 9573 1641 1657 2-s2.0-34248136340 10.1016/S0140-6736(07)60751-X (Pubitemid 46722637)
6. Cosnes J., Bourrier A., Nion-Larmurier I., Sokol H., Beaugerie L., Seksik P., Factors affecting outcomes in Crohn's disease over 15 years. Gut 2012 61 8 1140 1145 10.1136/gutjnl-2011-301971
7. Lennard-Jones J. E., Classification of inflammatory bowel disease. Scandinavian Journal of Gastroenterology, Supplement 1989 24 170 2 6 2-s2.0-0024810567 (Pubitemid 20015811)
8. Ogura Y., Bonen D. K., Inohara N., Nicolae D. L., Chen F. F., Ramos R., Britton H., Moran T., Karaliuskas R., Duerr R. H., Achkar J. P., Brant S. R., Bayless T. M., Kirschner B. S., Hanauer S. B., Nũez G., Cho J. H., A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 411 6837 603 606 2-s2.0-0035978533 10.1038/35079114 (Pubitemid 32531409)
9. Cuthbert A. P., Fisher S. A., Mirza M. M., King K., Hampe J., Croucher P. J. P., Mascheretti S., Sanderson J., Forbes A., Mansfield J., Schreiber S., Lewis C. M., Mathew C. G., The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 2002 122 4 867 874 2-s2.0-0036202885 (Pubitemid 34267268)
10. Clevers H., Inflammatory bowel disease, stress, and the endoplasmic reticulum. The New England Journal of Medicine 2009 360 7 726 727 2-s2.0-60549084729 10.1056/NEJMcibr0809591
11. Baumgart D. C., Carding S. R., Inflammatory bowel disease: cause and immunobiology. The Lancet 2007 369 9573 1627 1640 2-s2.0-34248136828 10.1016/S0140-6736(07)60750-8 (Pubitemid 46722636)
12. Jostins L., Ripke S., Weersma R. K., Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012 491 7422 119 124
13. Roggenbuck D., Reinhold D., Werner L., Schierack P., Bogdanos D. P., Conrad K., Glycoprotein 2 antibodies in Crohn's disease. Advances in Clinical Chemistry 2013 60 187 208 10.1016/B978-0-12-407681-5.00006-4
14. Saxon A., Shanahan F., Landers C., Ganz T., Targan S., A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. Journal of Allergy and Clinical Immunology 1990 86 2 202 210 2-s2.0-0025145696 10.1016/S0091-6749(05)80067-3 (Pubitemid 20288725)
15. Stöcker W., Otte M., Ulrich S., Normann D., Stöcker K., Jantschek G., Autoantiköper gegen exokrines Pankreas und gegen intestinale Becherzellen in der Diagnostik des Morbus Crohn und der Colitis ulcerosa. Deutsche Medizinische Wochenschrift 1984 109 1963 1969
16. Barthet M., Hastier P., Bernard J. P., Bordes G., Frederick J., Allio S., Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? American Journal of Gastroenterology 1999 94 8 2141 2148 2-s2.0-0033179771 10.1111/j.1572-0241.1999.01287.x (Pubitemid 29374545)
17. Conrad K., Schmechta H., Klafki A., Lobeck G., Uhlig H. H., Gerdi S., Henker J., Serological differentiation of inflammatory bowel diseases. European Journal of Gastroenterology and Hepatology 2002 14 2 129 135 2-s2.0-0036173674 10.1097/00042737-200202000-00006 (Pubitemid 34163991)
18. Roggenbuck D., Hausdorf G., Martinez-Gamboa L., Reinhold D., Büttner T., Jungblut P. R., Porstmann T., Laass M. W., Henker J., Büning C., Feist E., Conrad K., Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease. Gut 2009 58 12 1620 1628 2-s2.0-72549109556 10.1136/gut.2008.162495
19. Hoops T. C., Ivanov I., Cui Z., Colomer-Gould V., Rindler M. J., Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells. Journal of Biological Chemistry 1993 268 34 25694 25705 2-s2.0-0027377051 (Pubitemid 23358182)
20. Ronzio R. A., Kronquist K. E., Lewis D. S., Glycoprotein synthesis in the adult rat pancreas. IV. Subcellular distribution of membrane glycoproteins. Biochimica et Biophysica Acta 1978 508 1 65 84 2-s2.0-0017833853 (Pubitemid 8284636)
21. Gmez-Lzaro M., Rinn C., Aroso M., Amado F., Schrader M., Proteomic analysis of zymogen granules. Expert Review of Proteomics 2010 7 5 735 747 2-s2.0-77958539996 10.1586/epr.10.31
22. Rindler M. J., Hoops T. C., The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate. European Journal of Cell Biology 1990 53 1 154 163 2-s2.0-0025116390 (Pubitemid 20368195)
23. Hase K., Kawano K., Nochi T., Pontes G. S., Fukuda S., Ebisawa M., Kadokura K., Tobe T., Fujimura Y., Kawano S., Yabashi A., Waguri S., Nakato G., Kimura S., Murakami T., Iimura M., Hamura K., Fukuoka S. I., Lowe A. W., Itoh K., Kiyono H., Ohno H., Uptake through glycoprotein 2 of FimH + bacteria by M cells initiates mucosal immune response. Nature 2009 462 7270 226 230 2-s2.0-70449653428 10.1038/nature08529
24. Nguyen H. T. T., Amine A. B., Lafitte D., Waheed A. A., Nicoletti C., Villard C., Létisse M., Deyris V., Rozière M., Tchiakpe L., Danielle C. D., Comeau L., Hiol A., Proteomic characterization of lipid rafts markers from the rat intestinal brush border. Biochemical and Biophysical Research Communications 2006 342 1 236 244 2-s2.0-32644465438 10.1016/j.bbrc.2006.01.141 (Pubitemid 43247382)
25. Werner L., Paclik D., Fritz C., Reinhold D., Roggenbuck D., Sturm A., Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses. The Journal of Immunology 2012 189 6 2774 2783 10.4049/jimmunol.1103190
26. Säemann M. D., Weichhart T., Zeyda M., Staffler G., Schunn M., Stuhlmeier K. M., Sobanov Y., Stulnig T. M., Akira S., Von Gabain A., Von Ahsen U., Hörl W. H., Zlabinger G. J., Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. Journal of Clinical Investigation 2005 115 2 468 475 2-s2.0-20144373629 10.1172/JCI200522720 (Pubitemid 40385489)
27. Fukuoka S., Freedman S. D., Yu H., Sukhatme V. P., Scheele G. A., GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Proceedings of the National Academy of Sciences of the United States of America 1992 89 4 1189 1193 10.1073/pnas.89.4.1189
28. Komorowski L., Teegen B., Probst C., Autoantibodies against exocrine pancreas in Crohn's disease are directed against two antigens: the glycoproteins CUZD1 and GP2. Journal of Crohn's & Colitis 2012 10.1016/j.crohns.2012.10. 011
29. Roggenbuck D., Humbel R. L., Reinhold D., Bogdanos D. P., Conrad K., Laass M. W., Glycoprotein 2 antibodies in inflammatory bowel disease: no association with disease phenotype? Journal of Pediatric Gastroenterology and Nutrition 2012 56 1 e5 10.1097/MPG.0b013e318275fa77
30. Roggenbuck D., Bogdanos D., Conrad K., Loss of tolerance to one or two major targets in Crohn's disease or just cross-reactivity? Journal of Crohn's & Colitis 2013 10.1016/j.crohns.2012.12.013
31. Colomer V., Lal K., Hoops T. C., Rindler M. J., Exocrine granule specific packaging signals are present in the polypeptide moiety of the pancreatic granule membrane protein GP2 and in amylase: implications for protein targeting to secretory granules. The EMBO Journal 1994 13 16 3711 3719 2-s2.0-0028093660
32. Yu S., Michie S. A., Lowe A. W., Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion. Journal of Biological Chemistry 2004 279 48 50274 50279 2-s2.0-9644300973 10.1074/jbc.M410599200 (Pubitemid 39577842)
33. Kobayashi K., Yanagihara K., Ishiguro K., Fukuoka S., GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome. Biochemical and Biophysical Research Communications 2004 322 2 659 664 2-s2.0-6044233421 10.1016/j.bbrc.2004.07.197 (Pubitemid 39490353)
34. Pak J., Pu Y., Zhang Z. T., Hasty D. L., Wu X. R., Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. Journal of Biological Chemistry 2001 276 13 9924 9930 2-s2.0-0035971077 10.1074/jbc.M008610200
35. Dou W., Thompson-Jaeger S., Laulederkind S. J. F., Becker J. W., Montgomery J., Ruiz-Bustos E., Hasty D. L., Ballou L. R., Eastman P. S., Srichai B., Breyer M. D., Raghow R., Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections. American Journal of Physiology 2005 289 1 F49 F60 2-s2.0-20844457162 10.1152/ajprenal.00134.2004 (Pubitemid 40863572)
36. Yu S., Lowe A. W., The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli type 1 Fimbriae. BMC Gastroenterology 2009 9, article 58 2-s2.0-68949206485 10.1186/1471-230X-9-58
37. Hölzl M. A., Hofer J., Kovarik J. J., Roggenbuck D., Reinhold D., Goihl A., Gärtner M., Steinberger P., Zlabinger G. J., The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I). Cellular Immunology 2011 267 2 88 93 2-s2.0-79751525404 10.1016/j.cellimm.2010.12.001
38. Gullberg E., Söderholm J. D., Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease. Annals of the New York Academy of Sciences 2006 1072 218 232 2-s2.0-33749035296 10.1196/annals.1326.028 (Pubitemid 44448455)
39. Lakatos P. L., Papp M., Rieder F., Serologic antiglycan antibodies in inflammatory bowel disease. American Journal of Gastroenterology 2011 106 3 406 412 2-s2.0-79952361823 10.1038/ajg.2010.505
40. Dotan I., New serologic markers for inflammatory bowel disease diagnosis. Digestive Diseases 2010 28 3 418 423 2-s2.0-77957860638 10.1159/000320396
41. Bogdanos D. P., Rigopoulou E. I., Smyk D. S., Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies. Autoimmunity Reviews 2011 11 2 143 148 10.1016/j.autrev.2011.09.004
42. Roggenbuck D., Reinhold D., Wex T., Goihl A., von Arnim U., Malfertheiner P., Büttner T., Porstmann T., Porstmann S., Liedvogel B., Bogdanos D. P., Laass M. W., Conrad K., Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease. Clinica Chimica Acta 2011 412 9-10 718 724 2-s2.0-79951720546 10.1016/j.cca.2010.12.029
43. Pavlidis P., Mytilinaiou M. G., Roggenbuck D., Conrad K., Forbes A., Bogdanos D. P., Pancreatic GP2-specific autoantibodies are markers of Crohn's disease. Gut 2011 60 A212 A213 10.1136/gut.2011.239301.448
44. Op de Beeck K., Vermeire S., Rutgeerts P., Bossuyt X., Antibodies to GP2, the major zymogen granule membrane glycoprotein, in inflammatory bowel diseases. Gut 2010 61 1 162 164
45. Kovacs M., Lakatos P. L., Papp M., Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD). Journal of Pediatric Gastroenterology and Nutrition 2012 55 4 429 435
46. Bogdanos D. P., Roggenbuck D., Reinhold D., Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease. BMC Gastroenterology 2012 12 102 10.1186/1471-230X-12-102
47. Pavlidis P., Romanidou O., Roggenbuck D., Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease. Clinical and Developmental Immunology 2012 2012 8 640835 10.1155/2012/640835
48. Van Kruiningen H. J., West A. B., Freda B. J., Holmes K. A., Distribution of Peyer's patches in the distal ileum. Inflammatory Bowel Diseases 2002 8 3 180 185 2-s2.0-0036098915 (Pubitemid 34546044)
49. Darfeuille-Michaud A., Boudeau J., Bulois P., Neut C., Glasser A. L., Barnich N., Bringer M. A., Swidsinski A., Beaugerie L., Colombel J. F., High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004 127 2 412 421 2-s2.0-4143069158 10.1053/j.gastro.2004.04.061 (Pubitemid 39091889)
50. Rodríguez L. A. G., Ruigómez A., Panés J., Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease. Gastroenterology 2006 130 6 1588 1594 2-s2.0-33646381327 10.1053/j.gastro.2006. 02.004 (Pubitemid 43668828)
51. Rigopoulou E. I., Roggenbuck D., Smyk D. S., Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found. Autoimmunity Reviews 2012 12 2 260 269 10.1016/j.autrev.2012.04.005
52. Roggenbuck D., Mytilinaiou M. G., Lapin S. V., Reinhold D., Conrad K., Asialoglycoprotein Receptor (ASGPR): APeculiar Target of Liver-Specific Autoimmunity. Autoimmunity Highlights 2012 3 3 119 125 10.1007/s13317-012-0041-4