Loss of tolerance to one or two major targets in Crohn's disease or just cross-reactivity?

Journal of Crohn's and Colitis

Volumn 7, Issue 7, 2013, Pages

  Roggenbuck, Dirk ^a,b   Bogdanos, Dimitrios ^c   Conrad, Karsten ^d  

^a Lausitz University of Applied Sciences   (Germany)

^b GA GENERIC ASSAYS GMBH   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CUZD1 PROTEIN; GLYCOPROTEIN 2; IMMUNOGLOBULIN A; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; CELL SURFACE; CROHN DISEASE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOASSAY; INNATE IMMUNITY; LETTER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; TRANSLATION REGULATION; ULCERATIVE COLITIS; ZONA PELLUCIDA;

AUTOANTIBODIES; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GPI-LINKED PROTEINS; HUMANS; IMMUNE TOLERANCE; MEMBRANE PROTEINS;

EID: 84878658500     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2012.12.013     Document Type: Letter

References (5)

1. Komorowski L, Teegen B, Probst C, Aulinger-Stocker K, Sina C, Fellermann K, et al. Autoantibodies against exocrine pancreas in Crohn's disease are directed against two antigens: the glycoproteins CUZD1 and GP2. J Crohns Colitis in press. http://dx.doi.org/10.1016/j.crohns.2012.10.011.
2. Roggenbuck D., Hausdorf G., Martinez-Gamboa L., Reinhold D., Buttner T., Jungblut P.R., et al. Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease. Gut 2009, 58:1620-1628.
3. Bogdanos D.P., Rigopoulou E.I., Smyk D.S., Roggenbuck D., Reinhold D., Forbes A., et al. Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies. Autoimmun Rev 2011, 11:143-148.
4. Roggenbuck D, Humbel RL, Reinhold D, Bogdanos DP, Conrad K, Laass MW. Glycoprotein 2 antibodies in inflammatory bowel disease - no association with disease phenotype? J Pediatr Gastroenterol Nutr in press.
5. Werner L., Paclik D., Fritz C., Reinhold D., Roggenbuck D., Sturm A. Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses. J Immunol 2012, 189:2774-2783.