IBS Subjects with Methane on Lactulose Breath Test Have Lower Postprandial Serotonin Levels Than Subjects with Hydrogen

Digestive Diseases and Sciences

Volumn 49, Issue 1, 2004, Pages 84-87

  Pimentel, Mark ^a   Kong, Yuthana ^a   Park, Sandy ^a  

^a NONE

Author keywords

Irritable bowel syndrome; Lactulose breath test; Methane; Serotonin

Indexed keywords

GLUCOSE; HYDROGEN; LACTULOSE; METHANE; SEROTONIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; BREATH ANALYSIS; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIET RESTRICTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IRRITABLE COLON; MALE; MEAL; METABOLISM; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; QUESTIONNAIRE;

ADOLESCENT; ADULT; AGED; BREATH TESTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONSTIPATION; DIARRHEA; FEMALE; HUMANS; HYDROGEN; IRRITABLE BOWEL SYNDROME; LACTULOSE; MALE; METHANE; MIDDLE AGED; POSTPRANDIAL PERIOD; QUESTIONNAIRES; SEROTONIN;

EID: 0842269966     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DDAS.0000011607.24171.c0     Document Type: Article

References (36)

1. Thompson WG, Longstreth GF, Drossman DA, et al.: Functional bowel disorders and functional abdominal pain. Gut 45:II43-II47, 1999
2. Bertaccini G: Tissue 5-hydroxytryptamine and urinary 5- hydroxyindoleacetic acid after partial or total removal of the gastrointestinal tract in the rat. J Physiol (Lond) 153:239-249, 1960
3. Espramer V, Testini A: Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. J Pharm Pharmacol 11:618-623, 1959
4. Kim D-Y, Camilleri M. Serotonin: A mediator of the brain-gut connection. Am J Gastroenterol 95:2698-2709, 2000
5. Inokuchi H, Kawai K, Takeuchi Y, Sano Y: Immunohistochemical demonstration of EC cells in rat gastrointestinal tract. Histochemistry 74:453-456, 1982
6. Bülbring E, Lin RCY: The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J Physiol 140:381-407, 1958
7. Bülbring E, Crema A: Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol 13:444-457, 1958
8. Bülbring E, Crema A: The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea pigs. J Physiol 146:29-53, 1959
9. Costa M, Furness JB: The peristaltic reflex: An analysis of the nerve pathways and their pharmacology. Naunyn-Schmeidelberg Arch Pharmacol 294:47-60, 1976
10. Bearcroft CP, Perrett D, Farthing MJG: Postprandial plasma 5-hyroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 1998;42:42-46, 1998
11. Müller-Lissner SA, Fumagalli I, Bardhan KD, et al.: Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Alim Pharmacol Ther 15:1655-1666, 2001
12. Camilleri M, Chey WY, Mayer EA, et al.: A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 161:1733-1740, 2001
13. Camilleri M, Northcutt AR, Kong S, et al.: Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 355:1035-1040, 2000
14. Pimentel M, Chow EJ, Lin HC: Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95:3503-3506, 2000
15. Pimentel M, Chow EJ, Lin HC: Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: A double-blind, randomized placebo controlled study. Am J Gastroenterol 98:412-419, 2003
16. Pimentel M, Mayer AG, Park S, et al.: Methane production during lactulose breath test is associated with gastrointestinal disease presentation. Dig Dis Sci 48:86-92, 2003
17. Lin HC, Pimentel M, Chen JH: Intestinal transit is slowed by luminal methane. Neurogastroenterol Motil 4:437, 2002
18. Hede AR, Andersson L, Post C: Effect of homologous series of halogenated methanes on pulmonary uptake of 5-hydroxtryptamine in isolated perfused rat lung. Acta Pharmacol Toxicol 57:291-296, 1985
19. Drossman DA, Richter JE, et al. (eds): Functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment: a multinational consensus. Boston, Little, Brown, 1994
20. O'Hara R, Fox RO, Cole JW: Serotonin release mediated by intra-luminal sucrose solutions. Surg Forum 10:215, 1959
21. Drapana T, McDonald JC, Stewart JD: Serotonin release following instillation of hypertonic glucose into the proximal intestine. Ann Surg 156:528-536, 1962
22. Levitt MD: Production and excretion of hydrogen gas in man. N Engl J Med 281:122-127, 1969
23. Levitt MD, French P, Donaldson RM Jr: Use of hydrogen and methane excretion in the study of the intestinal flora. J Lab Clin Med 72:988, 1968 (abstr)
24. Bond JH Jr, Engel RR, Levitt MD: Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. J Exp Med 133:572-588, 1971
25. Levitt MD, Ingelfinger FJ: Hydrogen and methane production in man. Ann NY Acad Sci 150:75-81, 1968
26. Levitt MD, Bond JH Jr: Volume, composition and source of intestinal gas. Gastroenterology 59:921-929, 1970
27. Calloway DH, Murphy EL: The use of expired air to measure intestinal gas formation. Ann NY Acad Sci 150:82-95, 1968
28. Bond JH Jr, Engel RR, Levitt MD: Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. J Exp Med 133:572-588, 1971
29. Pitt P, DeBruijn KM, Beeching MF, et al.: Studies on breath methane: the effect of ethnic origins and lactulose. Gut 21:951-959, 1980
30. Bjorneklett A, Jenssen E: Relationship between hydrogen (H2) and methane (CH4) production in man. Scand J Gastroenterol 17:985-992, 1982
31. Stadtman TC: Methane fermentation. Annu Rev Microbiol 21:121-142, 1967
32. Fiedorek SC, Pumphrey CL, Casteel HB: Breath methane production in children with constipation and encoparesis. J Pediatr Gastroenterol 10:473-477, 1990
33. Weaver GA, Krause JA, Miller TL, Wollin MJ: Incidence of methanogenic bacteria in a sigmoidoscopy population: an association of methanogenic bacteria and diverticulosis. Gut 27:698-704, 1986
34. Bertaccini G: Tissue 5-hydroxytryptamine and urinary 5- hydroxyindoleacetic acid after partial or total removal of the gastrointestinal tract in the rat. J Physiol (Lond) 153:239-249, 1960
35. Espramer V, Testini A: Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. J Pharm Pharmacol 11:618-623, 1959
36. Kim D-Y, Camilleri M. Serotonin: A mediator of the brain-gut connection. Am J Gastroenterol 95:2698-2709, 2000