Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 304, Issue 10, 2013, Pages

  Zhang, Shizhong ^a   Grabauskas, Gintautas ^a   Wu, Xiaoyin ^a   Joo, Moon Kyung ^a   Heldsinger, Andrea ^a   Song, Il ^a   Owyang, Chung ^a   Yu, Shaoyong ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

C fiber; Esophagus; Mast cell; PGD2; Vagal afferent

Indexed keywords

1,1' DIOCTADECYL 3,3,3',3' TETRAMETHYLINDOCARBOCYANINE; MESSENGER RNA; PROSTAGLANDIN D2; 3,3' DIOCTADECYLINDOCARBOCYANINE; 3,3'-DIOCTADECYLINDOCARBOCYANINE; CARBOCYANINE; IMMUNOGLOBULIN RECEPTOR; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ESOPHAGUS; EVOKED RESPONSE; EX VIVO STUDY; GUINEA PIG; IMMUNOFLUORESCENCE; INHIBITION KINETICS; MALE; MAST CELL; NERVE ENDING; NODOSE GANGLION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE; SPINAL GANGLION; WESTERN BLOTTING; ANIMAL; C FIBER; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; FLUORESCENT ANTIBODY TECHNIQUE; INNERVATION; METABOLISM; NERVE FIBER; NONMYELINATED NERVE; PGD2; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; STATISTICAL ANALYSIS; STIMULATION; VAGAL AFFERENT; VAGUS NERVE;

C FIBER; ESOPHAGUS; MAST CELL; PGD2; VAGAL AFFERENT;

ACTION POTENTIALS; ANIMALS; BLOTTING, WESTERN; CARBOCYANINES; DATA INTERPRETATION, STATISTICAL; ESOPHAGUS; FLUORESCENT ANTIBODY TECHNIQUE; GUINEA PIGS; MALE; MAST CELLS; NERVE FIBERS; NERVE FIBERS, UNMYELINATED; NEURONS, AFFERENT; NODOSE GANGLION; PATCH-CLAMP TECHNIQUES; PHYSICAL STIMULATION; PROSTAGLANDIN D2; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; VAGUS NERVE;

MLCS; MLOWN;

EID: 84878660890     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00448.2012     Document Type: Article

References (34)

1. Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 126: 140-149, 2010.
2. Aharinejad S, Franz P, Sinzinger H, Firbas W. Esophageal prostaglandins in guinea pigs and rats. Acta Anat (Basel) 139: 66-69, 1990.
3. Barbara G, Stanghellini V, De Giorgio R, Corinaldesi R. Functional gastrointestinal disorders and mast cells: implications for therapy. Neurogastroenterol Motil 18: 6-17, 2006.
4. Buhner S, Schemann M. Mast cell-nerve axis with a focus on the human gut. Biochim Biophys Acta 1822: 85-92, 2012.
5. Cordoba-Rodriguez R, Moore KA, Kao JP, Weinreich D. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. Proc Natl Acad Sci USA 96: 7650-7657, 1999.
6. Cruz-Orengo L, Dhaka A, Heuermann RJ, Young TJ, Montana MC, Cavanaugh EJ, Kim D, Story GM. Cutaneous nociception evoked by 15d-PGJ2 via activation of ion channel TRPA1. Mol Pain 4: 30, 2008.
7. + currents in DRG neurons of adult rat. Pain 152: 1114-1126, 2011.
8. Eguchi N, Minami T, Shirafuji N, Kanaoka Y, Tanaka T, Nagata A, Yoshida N, Urade Y, Ito S, Hayaishi O. Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc Natl Acad Sci USA 96: 726-730, 1999.
9. 2+ influx in visceral afferent neurons. Brain Res 345: 345-349, 1985.
10. 2 on submucosal neurons and secretion in guinea pig colon. Am J Physiol Gastrointest Liver Physiol 266: G132-G139, 1994.
11. Gonsalves N, Yang GY, Doerfler B, Ritz S, Ditto AM, Hirano I. Elimination diet effectively treats eosinophilic esophagitis in adults: food reintroduction identifies causative factors. Gastroenterology 142: 1451-1459, 2012.
12. Grabauskas G, Song I, Zhou S, Owyang C. Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia. J Physiol 588: 617-632, 2010.
13. Grill M, Heinemann A, Hoefler G, Peskar BA, Schuligoi R. Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. J Neurochem 104: 1345-1357, 2008.
14. 2α to conscious mice. Eur J Pharmacol 122: 173-179, 1986.
15. Kajekar R, Undem BJ, Myers AC. Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. Am J Physiol Lung Cell Mol Physiol 284: L581-L587, 2003.
16. Kapel RC, Miller JK, Torres C, Aksoy S, Lash R, Katzka DA. Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. Gastroenterology 134: 1316-1321, 2008.
17. 2 mediates neuronal protection via the DP1 receptor. J Neurochem 92: 477-486, 2005.
18. Materazzi S, Nassini R, Andrè E, Campi B, Amadesi S, Trevisani M, Bunnett NW, Patacchini R, Geppetti P. COX-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 105: 12045-12050, 2008.
19. Page AJ, Blackshaw LA. Roles of gastro-oesophageal afferents in the mechanisms and symptoms of reflux disease. Hand Exp Pharmacol 194: 227-257, 2009.
20. Qin C, Farber JP, Foreman RD. Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats. Am J Physiol Gastrointest Liver Physiol 294: G708-G716, 2008.
21. Rueff A, Dray A. Sensitization of peripheral afferent fibres in the in vitro neonatal rat spinal cord-tail by bradykinin and prostaglandins. Neuroscience 54: 527-535, 1993.
22. Schuligoi R, Schmidt R, Geisslinger G, Kollroser M, Peskar BA, Heinemann A. PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. Biochem Pharmacol 74: 107-117, 2007.
23. Schuligoi R, Sturm E, Luschnig P, Konya V, Philipose S, Sedej M, Waldhoer M, Peskar BA, Heinemann A. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. Pharmacology 85: 372-382, 2010.
24. Shahbazian A, Heinemann A, Peskar BA, Holzer P. Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. Br J Pharmacol 137: 1047-1054, 2002.
25. Smith JA, Amagasu SM, Eglen RM, Hunter JC, Bley KR. Characterization of prostanoid receptor-evoked responses in rat sensory neurones. Br J Pharmacol 124: 513-523, 1998.
26. Taylor-Clark TE, Undem BJ, Macglashan DW Jr, Ghatta S, Carr MJ, McAlexander MA. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 73: 274-281, 2008.
27. 2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation. Neuroscience 156: 184-192, 2008.
28. 2α to conscious mice. Brain Res 510: 26-32, 1990.
29. Willingale HL, Gardiner NJ, McLymont N, Giblett S, Grubb BD. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br J Pharmacol 122: 1593-1604, 1997.
30. Yu LC, Perdue MH. Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress. Immunol Rev 179: 61-73, 2001.
31. Yu S, Gao G, Peterson BZ, Ouyang A. TRPA1 in mast cell activationinduced long-lasting mechanical hypersensitivity of vagal afferent C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol 297: G34-G42, 2009.
32. Yu S, Kollarik M, Ouyang A, Myers AC, Undem BJ. Mast cellmediated long-lasting increases in excitability of vagal C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol 293: G850-G856, 2007.
33. Yu S, Undem BJ, Kollarik M. Vagal afferent nerves with nociceptive properties in guinea-pig oesophagus. J Physiol 563: 831-842, 2005.
34. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther 322: 806-812, 2007.