Fabrication and characterization of genistein encapsulated poly (D, L) lactic acid nanoparticles for pharmaceutical application

Current Nanoscience

Volumn 9, Issue 2, 2013, Pages 293-302

  Ravikumara, N R ^a,b   Tiyaboonchai, Waree ^c   Madhusudhan, Basavaraj ^b  

^a KUVEMPU UNIVERSITY   (India)

^b DAVANGERE UNIVERSITY   (India)

^c NARESUAN UNIVERSITY   (Thailand)

Author keywords

Crystallization; Fickian diffusion; Hemolysis; Phytoestrogen; Sonication

Indexed keywords

ENCAPSULATION EFFICIENCY; FABRICATION AND CHARACTERIZATIONS; FICKIAN DIFFUSION; HEMOLYSIS; PHARMACEUTICAL APPLICATIONS; PHYTOESTROGENES; PREPARATION OF NANOPARTICLES; RELEASE CHARACTERISTICS;

BIOCHEMISTRY; BLOOD; CRYSTALLIZATION; DISEASES; DRUG DELIVERY; EMULSIFICATION; FLAVONOIDS; LACTIC ACID; NANOPARTICLES; SONICATION;

ENCAPSULATION;

GENISTEIN; NANOPARTICLE; POLYLACTIC ACID; POLYMER; SOLVENT; SURFACTANT;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DISPERSION; DRUG RELEASE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOLECULAR INTERACTION; NANOEMULSION; NANOENCAPSULATION; NANOFABRICATION; PARTICLE SIZE; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLVENT EFFECT; TEMPERATURE; TIME; TOXICITY TESTING; ULTRASOUND; ZETA POTENTIAL;

GLYCINE MAX;

EID: 84878654432     PISSN: 15734137     EISSN: 18756786     Source Type: Journal    
DOI: 10.2174/1573413711309020021     Document Type: Article

References (58)

1. Wu, Y.; Wuli, Y.; Wang, C.; Hu, J.; Fu, S. Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int. J. Pharm., 2005, 295, 235-245.
2. Desai, M.P.; Labhasetwar, V.; Amidon, G.L.; Levy, R.J. Gastrointestinal uptake of biodegradable microparticles effect of particle size. Pharm. Res., 1996, 13 (12), 1838-1845.
3. Gref, R.; Minamitake, Y.; Perracchia, M.T.; Trubeskoy, V.; Torchilin, V.; Langer, R. Biodegradable long-circulating polymeric nanospheres. Science, 1994, 263, 1600-1603.
4. Florence, A.T.; Hillery, A.M.; Hussain, N.; Jani, P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Release, 1995, 36, 39-46.
5. Ignatius, A.A.; Claes, L.E. In vitro biocompatibility of bioresorbable polymers: poly (L, DL-lactide) and poly (L-lactide-co-glycolide). Biomaterials, 1996, 17(8), 831-839.
6. Park, T.G.; Cohen, S.; Langer, R. Poly (L-lactic acid)/ pluronic blends: characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrices. Macromolecules, 1992, 25, 116-122.
7. Vert, M.; Li, S. M.; Spenlehauer, G.; Guerin, P. Bioresorbability and biocompatibility of aliphatic polyesters. J. Mater. Sci-Mater. Med., 1992, 3, 432-446.
8. Zhang, L.; Xiong, C.; Deng, X. Biodegradable polyesters blends for biomedical application. J. Appl. Poly. Sci., 1995, 56, 103-112.
9. Kulkarni, R.K.; Pani, K.C.; Neuman, C.; Leonard, F. Biodegradable poly (lactic acid) polymers. J. Biomed. Mater. Res., 1966, 5, 839-843.
10. Bazile, D.V.; Ropert, C.; Huve, P.; Verrecchia, T.; Marland, M.; Frydman, A.; Veillard, M.; Spenlehauer, G. Body distribution of fully biodegradable 14C-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats. Biomaterials, 1992, 13, 1093-1102.
11. Makino, K.; Arakawa, M.; Kondo, T. Preparation and in vitro degradation properties of polylactide microcapsules. Chem. Pharm. Bull., 1985, 33, 1195-1201.
12. Rodrigues, J.M. Jr.; Croft, S.L.; Fessi, H.; Bories, C.; Devissaguet, J. Ph. The activity and ultrastructural localization of primaquine-loaded poly (D,Llactide) nanoparticles in Leishmania donoani infected mice. Trop. Med. Parasitol., 1994, 45, 223-228.
13. Rodrigues, J.M. Jr.; Fessi, H.; Bories, C.; Puisieux, F.; Devissaguet, J.Ph. Primaquine-loaded poly(lactide) nanoparticles: physicochemical study and acute tolerance in mice. Int. J. Pharm., 1995, 126, 253-260.
14. Leroueil-Le Verger, M.; Fluckiger, L.; Kim, Y.-I.; Hoffman, M.; Maincent, P. Preparation and characterization of nanoparticles containing an antihypertensive agent. Eur. J. Pharm. Biopharm., 1998, 46, 137-143.
15. Chorny, M.; Fishbein, I.; Danenberg, H.D.; Golomb, G. Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J. Control. Release, 2002, 83, 389-400.
16. Wehrle, P.; Magenheim, B.; Benita, S. The influence of process parameters on the PLA nanoparticle size distribution, evaluated by means of factorial design. Eur. J. Pharm. Biopharm., 1995, 4, 19-26.
17. Guterres, S.S.; Fessi, H.; Barratt, G.; Devissaguet, J.P.; Puisieux, F. Poly (D,L-lactide) nanocapsules containing diclofenac: I. Formulation and stability study. Int. J. Pharm., 1995, 113, 57-63.
18. Cauchetier, E.; Deniau, M.; Fessi, H.; Astier, A.; Paul, M. Atovaquoneloaded nanocapsules: influence of the nature of the polymer on their in vitro characteristics. Int. J. Pharm., 2003, 250, 273-281.
19. Giannavola, C.; Bucolo, C.; Maltese, A.; Paolino, D.; Vandelli, M.A.; Puglisi, G.; Lee, V.H.L.; Fresta, M. Influence of preparation conditions on acyclovir-loaded poly-D,L-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability. Pharm. Res., 2003, 20, 584-590.
20. Santos-Magalhães, N.S.; Fessi, H.; Puisieux, F.; Benita, S.; Seiller, M. An in vitro release kinetic examination and comparative evaluation between submicron emulsion and polylactic acid nanocapsules of clofibride. J. Microencapsul., 1995, 12, 195-205.
21. Rodrigues Jr, J.M.; Fessi, H.; Bories, C.; Puisieux, F.; Devissaguet, J.P. Primaquine loaded poly (lactide) nanoparticles: physicochemical study and acute tolerance in mice. Int. J. Pharm., 1995, 126, 253-260.
22. Musumeci, T.; Ventura, C.A.; Giannone, I.; Ruozi, B.; Montenegro, L.; Pignatello, R.; Puglisi, G. PLA/PLGA nanoparticles for sustained release of docetaxel. Int. J. Pharm., 2006, 325, 172-179.
23. Layre, A.-M.; Gref, R.; Richard, J.; Requier, D.; Chacun, H.; Appel, M.; Domb, A.J.; Couvreur, P. Nanoencapsulation of a crystalline drug. Int. J. Pharm., 2005, 298, 323-327.
24. Bilati, U.; Allemann, E.; Doelker, E. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur. J. Pharm. Sci., 2005, 24, 67-75.
25. Mosqueira, V.C.F.; Legrand, P.; Pinto-Alphandary, H.; Puisieux, F.; Barratt, G. Poly (D, L-lactide) nanocapsules prepared by a solvent displacement process: influence of the composition on physicochemical and structural properties. J. Pharm. Sci., 2000, 89, 614-626.
26. Lemoine, D.; Francois, C.; Kedzierewicz, F.; Preat, V.; Hoffman, M.; Maincent, P. Stability study of nanoparticles of poly(ε-caprolactone), poly(D,Llactide) and poly(D,L-lactide-co-glycolide). Biomaterials, 1996, 17, 2191-2197.
27. Barnes, S. Effect of genistein on in vitro and in vivo models of cancer. J. Nutr. 1995, 125, 777-783S.
28. Adlercruetz, C.H.; Goldin, B.R.; Gorbach, S.L.; Hockerstedt, K.A.V.; Watanabe, S.; Hamalainen, E.; Markkanen, M.H.; Makela, T.H.; Wahala, K.T.; Hase, T.A.; Fotsis, T. Soybean phytoestrogen intake and cancer risk. J. Nutr., 1996, 125, 757S-770S.
29. Brownson, D.M.; Azios, N.G.; Fuqua, B.K.; Dharmawardhane, S.F.; Mabry, T.J. Flavonoid effects relevant to cancer. J. Nutr., 2002, 132, 3482S-3489S.
30. Kuiper, G. G. J. M.; Carlsson, B.; Grandien, K.; Enmark, E.; Haggblad, J.; Nilsson, S.; Gustafsson, J. A. Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β. Endocrinology, 1997, 138, 863-870.
31. Pike, A. C. W.; Brzozowski, A. M.; Hubbard, R. E.; Bonn, T.; Thorsell, A. G. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J., 1999, 18, 4608-4618.
32. Witkowska, H. E.; Carlquist, M.; Engstrom, O.; Carlsson, B.; Bonn, T.; Gustasson, J.A; Shackleton, C. H. L. Characterization of bacterially expressed rat estrogen receptor α ligand binding domain by mass spectrometry: structural comparison with estrogen receptor α. Steroids, 1997, 62, 621-631.
33. Knight D.C; Eden J. A review of the clinical effects of phytoestrogens. Maturitas, 1995, 22, 167-175.
34. Lamartiniere, C. A.; Moore, J.; Holland, M.; Barnes, S. Neonatal genistein chemo prevents mammary cancer. Proc. Soc. Exp. Biol. Med., 1995, 208, 120-123.
35. Constantinou, A. I.; Krygier, A. E.; Mehta, R. R. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am. J. Clin. Nutr., 1998, 68, 1426S-1430S.
36. Stancanelli, R., Mazzaglia, A., Tommasini, S., Calabrò, M. L., Villari, V., Guardo, M., Ficarra, P., and Ficarra, R. The enhancement of isoflavones water solubility by complexation with modified cyclodextrins: A spectroscopic investigation with implications in the pharmaceutical analysis. J. Pharm. Biomed. Anal., 2007, 44, 980-984.
37. Fritz, W.A.; Coward, L.; Wang, J.; Lamartiniere, C.A. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis, 1998, 19, 2151-2158.
38. Knight, D.C.; Eden, J.A. A review of the clinical effects of phytoestrogens, Obstet. Gynecol., 1996, 87, 897-904.
39. Kwon, S.H.; Kim, S.Y.; Ha, K.W.; Kang, M.J.; Huh, J.S.; Im, T.J.; Kim, Y.M.; Park, Y.M.; Kang, K.H.; Lee, S.; Chang, J.Y.; Lee, J.; Choi, Y.W. Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery. Arch. Pharm. Res., 2007, 30(9), 1138-1143.
40. Motlekar, N.; Khan, M.A.; Youan, B.B.C. Preparation and Characterization of Genistein Containing Poly(ethylene glycol) Microparticles, J. Appl. Polym. Sci., 2006, 101, 2070-2078.
41. Mahapatro, A.; Dinesh, K. Singh. Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines. J. Nanobiotechnol., 2011, 9, 55.
42. Zhu, S; Hong, M; Liu, C; Pei, Y. Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation. Pharm. Dev. Technol., 2009, 14, 642-649.
43. Si, H.Y.; Li, D.P.; Wang, T.M. Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system. J. Nanosci. Nanotechnol., 2010, 10, 2325-2331.
44. Liu, M.X.; Dong, J.; Yang, Y.J.; Yang, X.L.; Xu, H.B. Research on system of triptolide-loaded poly (d,l-lactic acid) nanoparticles. J. China. Pharm. University. 2004, 35, 117-121.
45. Ravikumara, N.R.; Nagaraj, T.S.; Hiremat, S. R.; Raina, G.; Madhusudhan, B. Preparation and evaluation of nimesulide-loaded ethylcellulose and methylcellulose nanoparticles and microparticles for oral delivery. J. Biomater. Appl., 2009, 24(1), 47-64.
46. Duane, T.; Birnbaum.; Jacqueline D.; Kosmala.; Peppas, L.B. Optimization of preparation techniques for poly (lactic acid-co-glycolic acid) nanoparticles. J. Nanopart. Res., 2000, 2, 173-181.
47. Mainardes, R.M.; Evangelista, R.C. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int. J. Pharm., 2005, 290, 137-144.
48. Yen, F.L.; Wu, T.H.; Lin, L.T.; Cham, T.M.; Lin, C.C. Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl4-induced acute liver failure. Pharm, Res., 2008, 26, 893-902.
49. Shah, P.P.; Mashru, R.C.; Rane, Y.M.; Thakkar, A. Design and optimization of mefloquine hydrochloride microparticles for bitter taste masking. AAPS. Pharm. Sci Tech., 2008, 9, 377-389.
50. Layre, A.M.; Gref, R.; Richard, J.; Requier, D.; Chacun, H.; Appel, M.; Dombc, A. J.; Couvreur, P. Nanoencapsulation of a crystalline drug. Int. J. Pharma., 2005, 298, 323-327.
51. Motlekar, N. Preparation and characterization of microparticulate systems for oral delivery of genistein, A Thesis in pharmaceutical sciences, Texas Tech University Health Sciences Center, 2003.
52. Silverstein, R. M.; Webster, F. X. Characteristic group frequencies of organic molecules; in Spectrometric Identification of Organic Compounds, John Wiley and Sons, New York, USA, 1997, pp. 95-180.
53. Cohn, D.; Younes, H. Biodegradable PEO/PLA block copolymers. J. Biomed. Mater. Res., 1988, 22 (11), 993-1009.
54. Xu, K.; Ahmet, K.; Emir, B. D.; Erhan, P. Poly (D, L-Lactic acid) Homopolymers: Synthesis and Characterization. Tr. J. Chem., 1996, 20, 43-53.
55. Sojitra, P.; Raval, A.; Kothwala, D.; Kotadia, H.; Adeshara, S. Covalently Conjugation of Genistein with Biodegradable Poly L-Lactide. Trends Biomater. Artif. Organs., 2010, 23(3), 144-148.
56. Vippagunta, S.R.; Maul, K.A.; Tallavajhala, S.; Grant, D.J.W. Solid-state characterization of nifedipine solid dispersions. Int. J. Pharm., 2002, 236, 111-123.
57. Hancock, B.C.; Carlson, G.T.; Ladipo, D.D.; Langdon, B.A.; Mullarney, M.P. Comparison of the mechanical properties of the crystalline and amorphous forms of a drug substance. Int. J. Pharm., 2002, 241, 73-85.
58. Corrigan, D.O.; Healy, A.M.; Corrigan, O.I. The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials. Int. J. Pharm., 2003, 262, 125-137.