Cellular assays of oncogene transformation

Cell Biology, Four-Volume Set

Volumn 1, Issue , 2006, Pages 345-352

  Booden, Michelle A ^b   Ulku, Aylin S ^a   Der, Channing J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84878644682     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012164730-8/50042-3     Document Type: Chapter

References (19)

1. Albini A., Iwamoto Y., Kleinman H.K., Martin G.R., Aaronson S.A., Kozlowski J.M., McEwan R.N. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 1987, 47:3239-3245.
2. Booden M.A., Campbell S.L., Der C.J. Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. Mol. Cell. Biol. 2002, 22:2487-2497.
3. Booden M.A., Eckert L.B., Der C.J., Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carconoma cell invasion. Mol. Cell. Biol. 2004, 24:1990-1999.
4. Clark E.A., Golub T.R., Lander E.S., Hynes R.O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000, 406:532-535.
5. Clark G.J., Cox A.D., Graham S.M., Der C.J. Biological assays for Ras transformation. Methods Enzymol. 1995, 255:395-412.
6. Eckert L.B., Repasky G.A., Ülkü A.S., McFall A., Zhou H., Sartor C.I., Der C.J. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res. 2004, 64:4585-4592.
7. Fabian J.R., Daar I.O., Morrison D.K. Critical tyrosine residues regulated the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 1993, 13:7170-7179.
8. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
9. Keely P.J., Westwick J.K., Whitehead I.P., Der C.J., Parise L.V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 1997, 390:632-636.
10. Khosravi-Far R., Solski P.A., Kinch M.S., Burridge K., Der C.J. Activation of Rac and Rho, and mitogen activated protein kinases, are required for Ras transformation. Mol. Cell. Biol. 1995, 15:6443-6453.
11. Martin C.B., Mahon G.M., Klinger M.B., Kay R.J., Symons M., Der C.J., Whitehead I.P. The thrombin receptor, PAR-1 causes transformation by activation of Rho-mediated signaling pathways. Oncogene 2001, 20:1953-1963.
12. Petersen O.W., Ronnov-Jessen L., Howlett A.R., Bissell M.J. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. USA 1992, 89:9064-9068.
13. Qiu R.-G., Chen J., Kirn D., McCormick F., Symons M. An essential role for Rac in Ras transformation. Nature 1995, 374:457-459.
14. Sahai E., Marshall C.J. RHO-GTPases and cancer. Nature Rev. Cancer 2002, 2:133-142.
15. Schmidt A., Hall A. Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch. Genes Dev. 2002, 16:1587-1609.
16. Solski P.A., Der C.J. Analyses of transforming activity of Rho family activators. Methods Enzymol. 2000, 325:425-441.
17. Whitehead I.P., Zohn I.E., Der C.J. Rho GTPase-dependent transformation by G protein-coupled receptors. Oncogene 2001, 20:1547-1555.
18. Yu Q., Stamenkovic I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev. 1999, 13:35-48.
19. Yu Q., Toole B.P., Stamenkovic I. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J. Exp. Med. 1997, 186:1985-1996.