Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 1, 2000, Pages 53-61

  Zhang, Jing ^a   Graham, Doyle G ^a   Montine, Thomas J ^a,b   Ho, Ye Shih ^c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

Author keywords

Glutathione peroxidase; Knockout mice; MPTP; Oxidative stress; Parkinson disease; Superoxide dismutase

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; TYROSINE 3 MONOOXYGENASE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NEUROCHEMISTRY; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0033969953     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.1.53     Document Type: Article

References (37)

1. Lowe J, Graham DI, Leigh PN. Disorders of movement and system degeneration. In: Graham DI, Lantos PL, eds. Greenfield's neuropathology. London: Arnold, 1997;281-366
2. Desai VG, Feuers RJ, Hart RW, Ali, SF. MPP(+)-induced neurotoxicity in mouse is age-dependent: Evidenced by the selective inhibition of complexes of electron transport. Brain Res 1996; 715:1-8
3. Gerlach M, Riederer P. Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man. J Neural Trans 1996;103:987-1041
4. Fahn S, Cohen G. The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it. Annals Neurol 1992;32:804-12
5. Magyar K, Szende B, Lengyel J, Tekes K. The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research. J Neural Trans 1996;48(Suppl):29-43
6. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nature Genetics 1997;17:206-10
7. Sriram K, Pai KS, Boyd MR, Ravindranath V. Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice. Brain Res 1997;749:44-52
8. Jenner P. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 1998;13:24-34
9. Smith TS, Bennett JP, Jr. Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions. Brain Res 1997;765: 183-88
10. Klivenyi P, St. Clair D, Wermer M, et al. Manganese superoxide dismutase overexpression attenuates MPTP toxicity. Neurobiol Dis 1998;5:253-58
11. Przedborski S, Kostic V, Jackson-Lewis V, et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 1992;12:1658-67
12. Lan J, Jiang DH. Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J Neural Trans 1997;104:469-81
13. Yurek DM, Deutch AY, Roth RH, Sladek JR, Jr. Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res 1989;497:250-59
14. Hantraye P, Brouillet E, Ferrante R, et al. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature Medicine 1996;2:1017-21
15. Halliwell B, Gutteridge JMC, Protection against oxidants in biological systems: The superoxide theory of oxygen toxicity. In: Halliwell B, Gutteridge JMC, eds. Free radicals in biology and medicine, 2nd Ed. Oxford, UK: Clarendon, 1989:186-87
16. Dexter DT, Wells FR, Lees AJ, et al. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 1989;52:1830-36
17. Hockenbery DM, Oltvai ZN, Yin XM, Milliman C, Land, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993;75:241-51
18. Ho YS, Gargano M, Cao J, Bronson RT, Heimler I, Hutz RJ. Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J Biol Chem 1998;273:7765-69
19. Ho YS, Magnenat JL, Bronson RT, et al. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 1997;272:16644-51
20. Zhang J, Su YF, Oury TD, Piantadosi, CA. Cerebral amino acids, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. Brain Res 1993;606:56-62
21. Sidman RL, Angevine JBJ, Pierce ET, Atlas of the mouse brain and spinal cord. Cambridge. Boston: Harvard University Press, 1971
22. Gerlach M, Russ H, Winker J, et al. Effects of nimodipine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced depletions in the biogenic amine levels in mice. Arzneimittel-Forschung 1993;43:413-15
23. Tatton NA, Kish SJ. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 1997;77: 1037-48
24. Schulz JB, Matthews RT, Muqit MM, Browne SE, Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 1995;64:936-39
25. Good PF, Hsu A, Werner P, Perl DP, Olanow CW. Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol 1998;57:338-42
26. Beckman JS, Beckman TW, Chen J. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87: 1620-24
27. Alam ZI, Jenner A, Daniel SE, et al. Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 1997;69:1196-1203
28. Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci USA 1996;93:2696-2701
29. Zhang, J, Perry, G, Smith, MA, et al. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 1999;154:1423-29
30. Di Monte DA, Royland JE, Anderson A, Castagnoli K, Castagnoli N, Jr, Langston JW. Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity. J Neurochem 1997;69:1771-73
31. Castagnoli K, Palmer S, Anderson A, Bueters T, Castagnoli N, Jr. The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Chem Res Toxicology 1997;10:364-68
32. Mackenzie GM, Jackson MJ, Jenner P, Marsden CD. Nitric oxide synthase inhibition and MPTP-induced toxicity in the common marmoset. Synapse 1997;26 301-16
33. Di Monte DA. Mitochondrial DNA and Parkinson's disease. Neurology 1991;41:38-42
34. Miyako K, Kai Y, Irie T, Takeshige K, Kang D. The content of intracellular mitochondrial DNA is decreased by 1-methyl-4-phenylpyridinium ion (MPP+). J Biol Chem 1997;272:9605-8
35. Schapira AH, Hartley A, Cleeter MW, Cooper JM. Free radicals and mitochondrial dysfunction in Parkinson's disease. Biochem Society Trans 1993;21:367-70
36. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973;134:707-16
37. Przedborski S, Jackson-Lewis V. Mechanisms of MPTP toxicity. Mov Disord 1998;13:35-38