Title efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 9, 2013, Pages

  Hosokawa, Sachiko ^a   Koseki, Hiroaki ^a   Nagashima, Michio ^a   Maeyama, Yoshihiro ^a   Yomogida, Kentaro ^a   Mehr, Chelsea ^a   Rutledge, Madeleine ^a   Greenfeld, Hannah ^a   Kaneki, Masao ^a   Tompkins, Ronald G ^a   Jeevendra Martyn, J A ^a   Yasuhara, Shingo E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Atg8 LC3; Autophagosome turnover and maturation; Autophagy; Burn injury; In vivo microscopy; Inhibitor; Muscle wasting; Phosphodiesterase; Sildenafil; Skeletal muscle; Tadalafil; Vardenafil

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; TADALAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BURN; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EXPERIMENTAL MODEL; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; MALE; MICROANGIOPATHY; MICROCIRCULATION; MOUSE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SKELETAL MUSCLE; SURVIVAL RATE; TURNOVER TIME;

ATG8/LC3; AUTOPHAGOSOME TURNOVER AND MATURATION; AUTOPHAGY; BURN INJURY; IN VIVO MICROSCOPY; MUSCLE WASTING; PHOSPHODIESTERASE 5 INHIBITOR; SILDENAFIL; SKELETAL MUSCLE; TADALAFIL; VARDENAFIL;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; BURNS; CARBOLINES; DNA; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION; MICROSCOPY, CONFOCAL; MUSCLE, SKELETAL; PHOSPHODIESTERASE 5 INHIBITORS; REGIONAL BLOOD FLOW; SURVIVAL; WOUND HEALING;

EID: 84878593389     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00078.2013     Document Type: Article

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