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Volumn 21, Issue 13, 2013, Pages 3873-3881
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Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment
a
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Author keywords
1H Imidazol 2 amine derivative; Guanidine bioisostere; Inhibitor; Macular edema; Vascular adhesion protein 1
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Indexed keywords
1H BENZIMIDAZOL 2 AMINE;
4 (2 PHENYLETHYL) 1H IMIDAZOL 2 AMINE;
4 PHENYL 1H IMIDAZOL 2 AMINE;
AGENTS ACTING ON THE EYE;
N [4 [2 [4 (2 AMINO 1H IMIDAZOL 4 YL)PHENYL]ETHYL]THIAZOL 2 YL]ACETAMIDE;
N [4 [2 [4 [(2 AMINO 1H IMIDAZOL 4 YL)ETHYL]PHENYL]ETHYL]THIAZOL 2 YL]ACETAMIDE;
N [4 [2 [4 [(2 AMINO 1H IMIDAZOL 4 YL)METHYL]PHENYL]ETHYL]THIAZOL 2 YL]ACETAMIDE;
PHENYLGUANIDINE;
PROTEIN INHIBITOR;
UNCLASSIFIED DRUG;
VASCULAR ADHESION PROTEIN 1;
AMINE;
AMINE OXIDASE (COPPER CONTAINING);
AOC3 PROTEIN, HUMAN;
CELL ADHESION MOLECULE;
THIAZOLE DERIVATIVE;
VASCULAR ADHESION PROTEIN-1, RAT;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
CONTROLLED STUDY;
DIABETIC MACULAR EDEMA;
DRUG BINDING;
DRUG EFFECT;
DRUG EFFICACY;
DRUG PENETRATION;
DRUG POTENCY;
DRUG SCREENING;
MALE;
MOLECULAR DOCKING;
NONHUMAN;
PROTEIN BLOOD LEVEL;
RAT;
STREPTOZOCIN DIABETES;
STRUCTURE ACTIVITY RELATION;
TREATMENT DURATION;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
CHEMICAL STRUCTURE;
CHEMISTRY;
COMPLICATION;
DIABETIC RETINOPATHY;
EXPERIMENTAL DIABETES MELLITUS;
HUMAN;
MACULAR EDEMA;
METABOLISM;
SPRAGUE DAWLEY RAT;
RATTUS;
AMINE OXIDASE (COPPER-CONTAINING);
AMINES;
ANIMALS;
CELL ADHESION MOLECULES;
DIABETES MELLITUS, EXPERIMENTAL;
DIABETIC RETINOPATHY;
HUMANS;
MACULAR EDEMA;
MALE;
MODELS, MOLECULAR;
MOLECULAR DOCKING SIMULATION;
RATS;
RATS, SPRAGUE-DAWLEY;
THIAZOLES;
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EID: 84878590884
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2013.04.011 Document Type: Article |
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Times cited : (29)
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References (21)
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