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Volumn 21, Issue 5, 2013, Pages 1219-1233
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Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema
a
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Author keywords
Guanidine; Inhibitor; Macular edema; Thiazole; VAP 1
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Indexed keywords
(2 AMINO 1,3 THIAZOL 4 YL)METHYL ACETATE;
1 [4 [2 (2 AMINO 1,3 THIAZOL 4 YL)ETHYL]PHENYL]GUANIDINE;
2 BROMOMALONALDEHYDE;
4 [2 (1,3 DIOXO 1,3, DIHYDRO 2H ISOINDOL 2 YL)ETHYL]BENZALDEHYDE;
[2 (ACETYLAMINO) 1,3 THIAZOL 4 YL]METHYL ACETATE;
[[2 (ACETYLAMINO) 1,3 THIAZOL 4 YL]METHYL](TRIPHENYL)PHOSPHONIUM CHLORIDE;
BENZYL 4 (HYDROXYMETHYL) 1,3 THIAZOL 2 YLCARBAMIC ACID;
ETHYL 2 (ISO BUTYRYLAMINO) 1,3 THIAZOLE 4 CARBOXYLIC ACID;
ETHYL 2 [[(BENZYLOXY)CARBONYL]AMINO] 1,3 THIAZOLE 4 CARBOXYLIC ACID;
ETHYL 2 AMINO 1,3 THIAZOLE 4 CARBOXYLATE HYDROBROMIDE;
METHYL N [4 [2 (2 ACETAMIDO 1,3 THIAZOL 4 YL)ETHYL]PHENYL]CARBAMIMIDOTHIOATE HYDROIODIDE;
N (4 (2 (4 (4,5 DIHYDRO 1,3 THIAZOL 2 YLAMINO)PHENYL)ETHYL) 1,3 THIAZOL 2 YL)ACETAMIDE;
N (4 (2 (4 AMINPHENYL)ETHYL) 1,3 THIAZOL 2 YL)ACETAMIDE;
N (4 FORMYL 1,3 THIAZOL 2 YL) 2 METHYLPROPANAMIDE;
N (4 FORMYL 1,3 THIAZOL 2 YL)ACETAMIDE;
N (5 FORMYL 1,3 THIAZOL 2 YL)ACETAMIDE;
N [3 [2 (4 AMINOPHENYL)ETHYL]PHENYL]ACETAMIDE;
N [3 [2 (4 CARBAMIMIDAMIDOPHENYL)ETHYL]PHENYL]ACETAMIDE;
N [4 (HYDROXYMETHYL) 1,3 THIAZOL 2 YL] 2 METHYLPROPANAMIDE;
N [4 (HYDROXYMETHYL) 1,3 THIAZOL 2 YL]ACETAMIDE;
N [4 [2 (4 AMINOPHENYL)ETHYL]PHENYL]ACETAMIDE;
N [4 [2 (4 CARBAMIMIDAMIDOPHENYL)ETHYL]PHENYL]ACETAMIDE;
N [4 [2 (4 NITROPHENYL)ETHENYL] 1,3 THIAZOL 2 YL]ACETAMIE;
N [4 [2 (4 NITROPHENYL)VINYL]PHENYL];
N [4 [2 [4 [[AMINO(IMINO)METHYL]AMINO]PHENYL]ETHYL] 1,3 THIAZOL 2 YL]ACETAMIDE;
N [5 [2 (4 AMINOPHENYL)ETHENYL] 1,3 THIAZOL 2 YL]ACETAMIDE;
N [5 [2 (4 NITROPHENYL)ETHENYL] 1,3 THIAZOL 2 YL]ACETAMIDE;
THIAZOLE DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
VASCULAR ADHESION PROTEIN 1 INHIBITOR;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
BLOOD VESSEL PERMEABILITY;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DIABETIC MACULAR EDEMA;
DRUG BLOOD LEVEL;
DRUG DOSE COMPARISON;
DRUG POTENCY;
DRUG SYNTHESIS;
HIGH THROUGHPUT SCREENING;
HUMAN;
IC 50;
IN VIVO STUDY;
MALE;
MOLECULAR DOCKING;
NONHUMAN;
OCULAR BLOOD VESSEL;
PHARMACOPHORE;
RAT;
REPEATED DRUG DOSE;
STREPTOZOCIN DIABETES;
STRUCTURE ACTIVITY RELATION;
AMINE OXIDASE (COPPER-CONTAINING);
ANIMALS;
BINDING SITES;
CELL ADHESION MOLECULES;
DIABETES COMPLICATIONS;
DIABETES MELLITUS, EXPERIMENTAL;
ENZYME INHIBITORS;
GUANIDINES;
HALF-LIFE;
HUMANS;
MACULAR EDEMA;
MALE;
MOLECULAR DOCKING SIMULATION;
PERMEABILITY;
PROTEIN STRUCTURE, TERTIARY;
RATS;
RATS, SPRAGUE-DAWLEY;
STRUCTURE-ACTIVITY RELATIONSHIP;
THIAZOLES;
RATTUS;
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EID: 84873743582
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.12.025 Document Type: Article |
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Times cited : (14)
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References (28)
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