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Volumn 123, Issue 6, 2013, Pages 2616-2628

Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; BORTEZOMIB; CASPASE 3; CASPASE 8; HISTONE H2AX; NUTLIN 3; PROPIDIUM IODIDE; PROTEIN MDM2; PROTEIN P53; VORINOSTAT;

EID: 84878572250     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI64503     Document Type: Article
Times cited : (61)

References (51)
  • 1
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995;332(18):1186-1191.
    • (1995) N Engl J Med , vol.332 , Issue.18 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3    Said, J.W.4    Knowles, D.M.5
  • 2
    • 0028588064 scopus 로고
    • Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    • Chang Y, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266(5192):1865-1869.
    • (1994) Science , vol.266 , Issue.5192 , pp. 1865-1869
    • Chang, Y.1
  • 3
    • 33744992899 scopus 로고    scopus 로고
    • Pathogenesis of viral lymphomas
    • Cesarman E, Mesri EA. Pathogenesis of viral lymphomas. Cancer Treat Res. 2006;131:49-88.
    • (2006) Cancer Treat Res , vol.131 , pp. 49-88
    • Cesarman, E.1    Mesri, E.A.2
  • 4
    • 0032514422 scopus 로고    scopus 로고
    • Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient
    • Jones D, et al. Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998;339(7):444-449.
    • (1998) N Engl J Med , vol.339 , Issue.7 , pp. 444-449
    • Jones, D.1
  • 5
  • 6
    • 22344455413 scopus 로고    scopus 로고
    • Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS
    • Boulanger E, et al. Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J Clin Oncol. 2005;23(19):4372-4380.
    • (2005) J Clin Oncol , vol.23 , Issue.19 , pp. 4372-4380
    • Boulanger, E.1
  • 7
    • 77957121811 scopus 로고    scopus 로고
    • Kaposi's sarcoma and its associated herpesvirus
    • Mesri EA, Cesarman E, Boshoff C. Kaposi's sarcoma and its associated herpesvirus. Nat Rev Cancer. 2010;10(10):707-719.
    • (2010) Nat Rev Cancer , vol.10 , Issue.10 , pp. 707-719
    • Mesri, E.A.1    Cesarman, E.2    Boshoff, C.3
  • 8
    • 1542571327 scopus 로고    scopus 로고
    • Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis
    • Grundhoff A, Ganem D. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest. 2004;113(1):124-136.
    • (2004) J Clin Invest , vol.113 , Issue.1 , pp. 124-136
    • Grundhoff, A.1    Ganem, D.2
  • 9
    • 0035136167 scopus 로고    scopus 로고
    • CREBbinding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50
    • Gwack Y, Byun H, Hwang S, Lim C, Choe J. CREBbinding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol. 2001;75(4):1909-1917.
    • (2001) J Virol , vol.75 , Issue.4 , pp. 1909-1917
    • Gwack, Y.1    Byun, H.2    Hwang, S.3    Lim, C.4    Choe, J.5
  • 10
    • 0032167919 scopus 로고    scopus 로고
    • A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
    • Sun R, Lin SF, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1998;95(18):10866-10871.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.18 , pp. 10866-10871
    • Sun, R.1    Lin, S.F.2    Gradoville, L.3    Yuan, Y.4    Zhu, F.5    Miller, G.6
  • 11
    • 34249930267 scopus 로고    scopus 로고
    • Addition of histone deacetylase inhibitors in combination therapy
    • Carraway HE, Gore SD. Addition of histone deacetylase inhibitors in combination therapy. J Clin Oncol. 2007;25(15):1955-1956.
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1955-1956
    • Carraway, H.E.1    Gore, S.D.2
  • 12
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007;26(37):5541-5552.
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 13
    • 65449148344 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    • Contreras X, et al. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem. 2009;284(11):6782-6789.
    • (2009) J Biol Chem , vol.284 , Issue.11 , pp. 6782-6789
    • Contreras, X.1
  • 14
    • 77955590822 scopus 로고    scopus 로고
    • Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
    • Sarosiek KA, et al. Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma. Proc Natl Acad Sci U S A. 2010;107(29):13069-13074.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.29 , pp. 13069-13074
    • Sarosiek, K.A.1
  • 15
    • 33144469102 scopus 로고    scopus 로고
    • The proteasome and proteasome inhibitors in cancer therapy
    • Voorhees PM, Orlowski RZ. The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol. 2006;46:189-213.
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 189-213
    • Voorhees, P.M.1    Orlowski, R.Z.2
  • 16
    • 58149359269 scopus 로고    scopus 로고
    • A case of HIV-negative primary effusion lymphoma treated with bortezomib, pegylated liposomal doxorubicin, and rituximab
    • Siddiqi T, Joyce RM. A case of HIV-negative primary effusion lymphoma treated with bortezomib, pegylated liposomal doxorubicin, and rituximab. Clin Lymphoma Myeloma. 2008;8(5):300-304.
    • (2008) Clin Lymphoma Myeloma , vol.8 , Issue.5 , pp. 300-304
    • Siddiqi, T.1    Joyce, R.M.2
  • 17
    • 33744539521 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
    • Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood. 2006;107(12):4907-4916.
    • (2006) Blood , vol.107 , Issue.12 , pp. 4907-4916
    • Obeng, E.A.1    Carlson, L.M.2    Gutman, D.M.3    Harrington Jr., W.J.4    Lee, K.P.5    Boise, L.H.6
  • 18
    • 24644517593 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells
    • Matta H, Chaudhary PM. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther. 2005;4(1):77-82.
    • (2005) Cancer Biol Ther , vol.4 , Issue.1 , pp. 77-82
    • Matta, H.1    Chaudhary, P.M.2
  • 19
    • 0034287445 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells
    • Keller SA, Schattner EJ, Cesarman E. Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood. 2000;96(7):2537-2542.
    • (2000) Blood , vol.96 , Issue.7 , pp. 2537-2542
    • Keller, S.A.1    Schattner, E.J.2    Cesarman, E.3
  • 20
    • 33645748053 scopus 로고    scopus 로고
    • NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo
    • Keller SA, et al. NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood. 2006;107(8):3295-3302.
    • (2006) Blood , vol.107 , Issue.8 , pp. 3295-3302
    • Keller, S.A.1
  • 21
    • 34547425829 scopus 로고    scopus 로고
    • Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen
    • Bubman D, Guasparri I, Cesarman E. Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene. 2007;26(34):4979-4986.
    • (2007) Oncogene , vol.26 , Issue.34 , pp. 4979-4986
    • Bubman, D.1    Guasparri, I.2    Cesarman, E.3
  • 22
    • 34247613416 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation
    • Liu J, Martin H, Shamay M, Woodard C, Tang QQ, Hayward SD. Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation. J Virol. 2007;81(9):4722-4731.
    • (2007) J Virol , vol.81 , Issue.9 , pp. 4722-4731
    • Liu, J.1    Martin, H.2    Shamay, M.3    Woodard, C.4    Tang, Q.Q.5    Hayward, S.D.6
  • 23
    • 0033599006 scopus 로고    scopus 로고
    • P53 inhibition by the LANA protein of KSHV protects against cell death
    • Friborg J Jr, Kong W, Hottiger MO, Nabel GJ. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature. 1999;402(6764):889-894.
    • (1999) Nature , vol.402 , Issue.6764 , pp. 889-894
    • Friborg Jr., J.1    Kong, W.2    Hottiger, M.O.3    Nabel, G.J.4
  • 25
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A. 1999;96(24):13777-13782.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.24 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 26
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307-310.
    • (2000) Nature , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 27
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry WS, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75(4):817-825.
    • (1993) Cell , vol.75 , Issue.4 , pp. 817-825
    • El-Deiry, W.S.1
  • 28
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia AJ, Kastan MB. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 1998;12(19):2973-2983.
    • (1998) Genes Dev , vol.12 , Issue.19 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 29
    • 0032539890 scopus 로고    scopus 로고
    • A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
    • Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998; 95(6):3003-3007.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.6 , pp. 3003-3007
    • Richon, V.M.1
  • 30
    • 66149121016 scopus 로고    scopus 로고
    • Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: A mechanism for synergy in leukemia cells
    • Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood. 2009;113(18):4289- 4299.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4289-4299
    • Miller, C.P.1    Rudra, S.2    Keating, M.J.3    Wierda, W.G.4    Palladino, M.5    Chandra, J.6
  • 31
    • 84859455667 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically
    • Sato A, Asano T, Ito K, Sumitomo M, Asano T. Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically. BJU Int. 2012;109(8):1258-1268.
    • (2012) BJU Int , vol.109 , Issue.8 , pp. 1258-1268
    • Sato, A.1    Asano, T.2    Ito, K.3    Sumitomo, M.4    Asano, T.5
  • 32
    • 77955871803 scopus 로고    scopus 로고
    • Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma
    • Kikuchi J, et al. Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma. Blood. 2010;116(3):406-417.
    • (2010) Blood , vol.116 , Issue.3 , pp. 406-417
    • Kikuchi, J.1
  • 33
    • 0037112901 scopus 로고    scopus 로고
    • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
    • Ito A, et al. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J. 2002;21(22):6236-6245.
    • (2002) EMBO J , vol.21 , Issue.22 , pp. 6236-6245
    • Ito, A.1
  • 34
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 1997;420(1):25-27.
    • (1997) FEBS Lett , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 35
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation is indispensable for p53 activation
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gu W. Acetylation is indispensable for p53 activation. Cell. 2008; 133(4):612-626.
    • (2008) Cell , vol.133 , Issue.4 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gu, W.5
  • 36
    • 34147158893 scopus 로고    scopus 로고
    • Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas
    • Sarek G, et al. Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas. J Clin Invest. 2007;117(4):1019-1028.
    • (2007) J Clin Invest , vol.117 , Issue.4 , pp. 1019-1028
    • Sarek, G.1
  • 37
    • 0036677565 scopus 로고    scopus 로고
    • Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha
    • Wu FY, et al. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc Natl Acad Sci U S A. 2002;99(16):10683-10688.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.16 , pp. 10683-10688
    • Wu, F.Y.1
  • 38
    • 0032892691 scopus 로고    scopus 로고
    • Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells
    • Yu Y, Black JB, Goldsmith CS, Browning PJ, Bhalla K, Offermann MK. Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J Gen Virol. 1999;80(pt 1):83-90.
    • (1999) J Gen Virol , vol.80 , Issue.PART 1 , pp. 83-90
    • Yu, Y.1    Black, J.B.2    Goldsmith, C.S.3    Browning, P.J.4    Bhalla, K.5    Offermann, M.K.6
  • 39
    • 25444459935 scopus 로고    scopus 로고
    • Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus
    • Brown HJ, McBride WH, Zack JA, Sun R. Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. Antivir Ther. 2005;10(6):745-751.
    • (2005) Antivir Ther , vol.10 , Issue.6 , pp. 745-751
    • Brown, H.J.1    McBride, W.H.2    Zack, J.A.3    Sun, R.4
  • 40
    • 65449183853 scopus 로고    scopus 로고
    • Viral avoidance and exploitation of the ubiquitin system
    • Randow F, Lehner PJ. Viral avoidance and exploitation of the ubiquitin system. Nat Cell Biol. 2009;11(5):527-534.
    • (2009) Nat Cell Biol , vol.11 , Issue.5 , pp. 527-534
    • Randow, F.1    Lehner, P.J.2
  • 41
    • 18544373405 scopus 로고    scopus 로고
    • The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production
    • Klass CM, Krug LT, Pozharskaya VP, Offermann MK. The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production. Blood. 2005;105(10):4028-4034.
    • (2005) Blood , vol.105 , Issue.10 , pp. 4028-4034
    • Klass, C.M.1    Krug, L.T.2    Pozharskaya, V.P.3    Offermann, M.K.4
  • 42
    • 66149155481 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines
    • Lefort S, Flamand L. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines. J Virol. 2009;83(11):5869-5880.
    • (2009) J Virol , vol.83 , Issue.11 , pp. 5869-5880
    • Lefort, S.1    Flamand, L.2
  • 44
    • 33947419410 scopus 로고    scopus 로고
    • Virus-associated tumor imaging by induction of viral gene expression
    • Fu DX, et al. Virus-associated tumor imaging by induction of viral gene expression. Clin Cancer Res. 2007;13(5):1453-1458.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1453-1458
    • Fu, D.X.1
  • 45
    • 34249736408 scopus 로고    scopus 로고
    • P53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors
    • Yu D, Carroll M, Thomas-Tikhonenko A. p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors. Blood. 2007; 109(11):4936-4943.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4936-4943
    • Yu, D.1    Carroll, M.2    Thomas-Tikhonenko, A.3
  • 46
    • 33947255054 scopus 로고    scopus 로고
    • Apoptosis induced by proteasome inhibition in cancer cells: Predominant role of the p53/PUMA pathway
    • Concannon CG, et al. Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway. Oncogene. 2007; 26(12):1681-1692.
    • (2007) Oncogene , vol.26 , Issue.12 , pp. 1681-1692
    • Concannon, C.G.1
  • 47
    • 79251473091 scopus 로고    scopus 로고
    • Proteasome inhibitors induce p53-independent apoptosis in human cancer cells
    • Pandit B, Gartel AL. Proteasome inhibitors induce p53-independent apoptosis in human cancer cells. Am J Pathol. 2011;178(1):355-360.
    • (2011) Am J Pathol , vol.178 , Issue.1 , pp. 355-360
    • Pandit, B.1    Gartel, A.L.2
  • 48
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood. 2006; 107(1):257-264.
    • (2006) Blood , vol.107 , Issue.1 , pp. 257-264
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 49
    • 0029121668 scopus 로고
    • In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences
    • Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood. 1995;86(7):2708-2714.
    • (1995) Blood , vol.86 , Issue.7 , pp. 2708-2714
    • Cesarman, E.1    Moore, P.S.2    Rao, P.H.3    Inghirami, G.4    Knowles, D.M.5    Chang, Y.6
  • 50
    • 0029796383 scopus 로고    scopus 로고
    • Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus
    • Arvanitakis L, et al. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood. 1996; 88(7):2648-2654.
    • (1996) Blood , vol.88 , Issue.7 , pp. 2648-2654
    • Arvanitakis, L.1
  • 51
    • 33847619373 scopus 로고    scopus 로고
    • In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: A cell and animal model of virally induced Kaposi's sarcoma
    • Mutlu AD, et al. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007;11(3):245-258.
    • (2007) Cancer Cell , vol.11 , Issue.3 , pp. 245-258
    • Mutlu, A.D.1


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