Identifying Hypoxia in a Newborn Piglet Model Using Urinary NMR Metabolomic Profiling

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Skappak, Christopher ^a   Regush, Shana ^a   Cheung, Po Yin ^a   Adamko, Darryl J ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLNICOTINAMIDE; 2 OXOGLUTARIC ACID; ACETURIC ACID; ALANINE; AMINO ACID DERIVATIVE; ASPARAGINE; BETAINE; CITRIC ACID; CREATINE; FUMARIC ACID; HIPPURIC ACID; LACTIC ACID; N CARBAMOYL BETA ALANINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; MALE; METABOLITE; METABOLOMICS; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PIGLET; PREDICTION; URINALYSIS;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; MALE; METABOLOME; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SWINE;

ANIMALIA;

EID: 84878567237     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065035     Document Type: Article

References (35)

1. Cheung PY, Robertson CM, (2000) Predicting the outcome of term neonates with intrapartum asphyxia. Acta paediatrica 89 (3): 262-264.
2. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, et al. (2005) Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353 (15): 1574-1584 doi:10.1056/NEJMcps050929.
3. Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, et al. (2012) Childhood outcomes after hypothermia for neonatal encephalopathy. The New England journal of medicine 366 (22): 2085-2092 doi:10.1056/NEJMoa1112066.
4. Fanos V, Barberini L, Antonucci R, Atzori L, (2011) Metabolomics in neonatology and pediatrics. Clin Biochem 44 (7): 452-454 doi:10.1016/j.clinbiochem.2011.03.006.
5. Solberg R, Enot D, Deigner HP, Koal T, Scholl-Burgi S, et al. (2010) Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. PloS one 5 (3): e9606 doi:10.1371/journal.pone.0009606.
6. Atzori L, Xanthos T, Barberini L, Antonucci R, Murgia F, et al. (2010) A metabolomic approach in an experimental model of hypoxia-reoxygenation in newborn piglets: urine predicts outcome. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 23Suppl 3: 134-137 doi:10.3109/14767058.2010.517033.
7. Douglas-Escobar M, Yang C, Bennett J, Shuster J, Theriaque D, et al. (2010) A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy. Pediatr Res 68 (6): 531-536 doi:10.1203/PDR.0b013e3181f85a03.
8. Liu JQ, Lee TF, Bigam DL, Cheung PY, (2010) Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets. PloS one 5 (12): e15322 doi:10.1371/journal.pone.0015322.
9. Cheung PY, Gill RS, Bigam DL (2011) A swine model of neonatal asphyxia. Journal of visualized experiments: JoVE (56). doi:10.3791/3166.
10. Saude EJ, Sykes BD, (2007) Urine stability for metabolomic studies: effects of preparation and storage. Metabolomics 3: 19-27.
11. Casey BM, McIntire DD, Leveno KJ, (2001) The continuing value of the Apgar score for the assessment of newborn infants. The New England journal of medicine 344 (7): 467-471 doi:10.1056/NEJM200102153440701.
12. Gilstrap LC 3rd, Hauth JC, Hankins GD, Beck AW (1987) Second-stage fetal heart rate abnormalities and type of neonatal acidemia. Obstetrics and gynecology 70 (2): 191-195.
13. da Silva S, Hennebert N, Denis R, Wayenberg JL, (2000) Clinical value of a single postnatal lactate measurement after intrapartum asphyxia. Acta paediatrica 89 (3): 320-323.
14. Shah S, Tracy M, Smyth J, (2004) Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia. Journal of perinatology: official journal of the California Perinatal Association 24 (1): 16-20 doi:10.1038/sj.jp.7211023.
15. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, et al. (2005) Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365 (9460): 663-670 doi:-10.1016/S0140-6736(05)17946-X.
16. White CR, Doherty DA, Henderson JJ, Kohan R, Newnham JP, et al. (2012) Accurate prediction of hypoxic-ischaemic encephalopathy at delivery: a cohort study. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. doi:10.3109/14767058.2011.653421.
17. Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, et al. (2011) Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics 128 (1): e112-120 doi:-10.1542/peds.2010-2036.
18. McArdle CB, Richardson CJ, Hayden CK, Nicholas DA, Amparo EG, (1987) Abnormalities of the neonatal brain: MR imaging. Part II. Hypoxic-ischemic brain injury. Radiology 163 (2): 395-403.
19. Rutherford M, Malamateniou C, McGuinness A, Allsop J, Biarge MM, et al. (2010) Magnetic resonance imaging in hypoxic-ischaemic encephalopathy. Early human development 86 (6): 351-360 doi:10.1016/j.earlhumdev.2010.05.014.
20. Haiju Z, Suyuan H, Xiufang F, Lu Y, Sun R, (2008) The combined detection of umbilical cord nucleated red blood cells and lactate: early prediction of neonatal hypoxic ischemic encephalopathy. J Perinat Med 36 (3): 240-247 doi:10.1515/JPM.2008.035.
21. Van Cappellen, Van Walsum AM, Jongsma HW, Wevers RA, Nijhuis JG, et al. (2002) 1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery. Pediatr Res 52 (1): 56-63 doi:--10.1203/00006450-200207000-00012.
22. Rafalowska U, (1979) Transport of malate and citrate into rat brain mitochondria under hypoxia and anesthesia. Neurochem Res 4 (3): 355-364.
23. Fitch CD, Sinton DW, (1964) A Study of Creatine Metabolism in Diseases Causing Muscle Wasting. J Clin Invest 43: 444-452 doi:10.1172/JCI104929.
24. Sartini S, Sestili P, Colombo E, Martinelli C, Bartolini F, et al. (2012) Creatine affects in vitro electrophysiological maturation of neuroblasts and protects them from oxidative stress. J Neurosci Res 90 (2): 435-446 doi:10.1002/jnr.22762.
25. Nelson DL, Lehninger AL, Cox MM (2008) Lehninger principles of biochemistry. 5th edn. W.H. Freeman, New York.
26. Van Coster RN, Gerlo EA, Giardina TG, Engelke UF, Smet JE, et al. (2005) Aminoacylase I deficiency: a novel inborn error of metabolism. Biochem Biophys Res Commun 338 (3): 1322-1326 doi:10.1016/j.bbrc.2005.10.126.
27. Griffin JL, Rae C, Dixon RM, Radda GK, Matthews PM, (1998) Excitatory amino acid synthesis in hypoxic brain slices: does alanine act as a substrate for glutamate production in hypoxia? J Neurochem 71 (6): 2477-2486.
28. Lever M, Slow S, (2010) The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 43 (9): 732-744 doi:10.1016/j.clinbiochem.2010.03.009.
29. Olli K, Lahtinen S, Rautonen N, Tiihonen K (2012) Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes. Br J Nutr: 1-7. doi:10.1017/S0007114512000888.
30. Jung JY, Lee HS, Kang DG, Kim NS, Cha MH, et al. (2011) 1H-NMR-based metabolomics study of cerebral infarction. Stroke 42 (5): 1282-1288 doi:10.1161/STROKEAHA.110.598789.
31. Homocysteine and risk of ischemic heart disease, stroke: a meta-analysis, (2002) Jama 288. (16): 2015-2022.
32. Vairetti M, Carini R, De Cesaris MG, Splendore R, Richelmi P, et al. (2002) Beta-alanine protection against hypoxic liver injury in the rat. Biochim Biophys Acta 1587 (1): 83-91.
33. Gebicki J, Sysa-Jedrzejowska A, Adamus J, Wozniacka A, Rybak M, et al. (2003) 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin. Pol J Pharmacol 55 (1): 109-112.
34. Dragun P, Makarewicz D, Wojcik L, Ziemka-Nalecz M, Slomka M, et al. (2008) Matrix metaloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA). J Physiol Pharmacol 59 (3): 441-455.
35. Drewes LR, Conway WP, Gilboe DD, (1977) Blood-brain amino acid transport and content during anoxia and reoxygenation. Am J Physiol 233 (4): E326-330.