1H-NMR spectroscopy of cerebrospinal fluid of fetal sheep during hypoxia-induced acidemia and recovery

Pediatric Research

Volumn 52, Issue 1, 2002, Pages 56-63

  Van Cappellen Van Walsum, Anne Marie ^a,c   Jongsma, Henk W ^a   Wevers, Ron A ^a   Nijhuis, Jan G ^a,b   Crevels, Jane ^a   Engelke, Udo F H ^a   De Abreu, Ronny A ^a   Moolenaar, Sytske H ^a   Oeseburg, Berend ^a   Nijland, Roel ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE; CHOLINE; CITRIC ACID; CREATININE; EXCITATORY AMINO ACID; GLUCOSE; HYPOXANTHINE; INOSITOL; LACTIC ACID; PYRUVIC ACID; SUCCINIC ACID; VALINE; PROTON;

ACIDEMIA; AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PH; ARTICLE; CELL MEMBRANE; CELL METABOLISM; CELL SWELLING; CEREBROSPINAL FLUID; CONTROLLED STUDY; EQUIPMENT; FEMALE; FETUS; FETUS HYPOXIA; METABOLITE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OSMOLALITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SHEEP; UTERUS BLOOD FLOW; ACIDOSIS; ANIMAL; ANOXIA; ENERGY METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREGNANCY;

3-HYDROXYBUTYRIC ACID; ACIDOSIS; ANIMALS; ANOXIA; CHOLINE; CITRIC ACID; CREATININE; ENERGY METABOLISM; FEMALE; GLUCOSE; HYPOXANTHINE; INOSITOL; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; PREGNANCY; PROTONS; PYRUVIC ACID; SHEEP; SUCCINIC ACID; VALINE;

EID: 0035998781     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200207000-00012     Document Type: Article

References (27)

1. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity
2. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: Evidence for apoptosis during selective neuronal loss
3. Hypoxanthine, xanthine and uridine in body fluids, indicators of ATP depletion
4. CSF lactate levels in high risk neonates with and without asphyxia
5. Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: Relationship to hypoxic-ischemic encephalopathy
6. Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and adenosine: High concentrations of the ATP metabolite, hypoxanthine, after hypoxia
7. Standardized method for high-resolution I H-NMR of cerebrospinal fluid
8. Cerebral oxidative metabolism in fetal sheep with prolonged and graded hypoxemia
9. Contribution of heart muscle, liver, skeletal muscle and placenta to the asphyxial hypoxanthine elevation in the acutely exteriorised fetal lamb
10. Neuronal uridine metabolism
11. The relationship of asphyxia in the mature fetus to long-term neurologic function
12. Effects of asphyxia on the fetal lamb brain
13. Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep
14. 1H-NMR spectroscopy of cerebrospinal fluid
15. Glycerol 3-phosphate and lactate as indicators of the cerebral cytoplasmic redox state in severe and mild hypoxia respectively: A 13C- and 31P-n.m.r. study
16. Calcium-related damage in ischemia
17. Induction of Na+/myo-inositol cotransporter mRNA after focal cerebral ischemia: Evidence for extensive osmotic stress in remote areas
18. Focal ischemia enhances choline output and decreases acetylcholine output from rat cerebral cortex
19. Cerebral arteriovenous difference for hypoxanthine and lactate during graded asphyxia in the fetal lamb
20. Effects of surgery and asphyxia on levels of nucleosides, purine bases, and lactate in cerebrospinal fluid of fetal lambs
21. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants
22. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
23. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years
24. Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain damage in the rat
25. Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep
26. Cerebral alanine transport and alanine aminotransferase reaction: Alanine as a source of neuronal glutamate
27. Excitatory amino acid synthesis in hypoxic brain slices: Does alanine act as a substrate for glutamate production in hypoxia?