A swine model of neonatal asphyxia

Journal of Visualized Experiments

Volumn , Issue 56, 2011, Pages

  Cheung, Po Yin ^a   Gill, Richdeep S ^a   Bigam, David L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Asphyxia; Developmental biology; Hypoxia; Issue 56; Medicine; Newborn; Pigs; Reoxygenation

Indexed keywords

EID: 80054931770     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3166     Document Type: Article

References (16)

1. Borke, W.B., et al. Increased myocardial matrix metalloproteinases in hypoxic newborn pigs during resuscitation: effects of oxygen and carbon dioxide. Eur. J. Clin. Invest. 34, 459-466 (2004).
2. Munkeby, B.H, et al. Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8. Pediatr. Res. 58, 542-548 (2005).
3. Haaland, K., et al. Posthypoxic hypothermia in newborn piglets. Pediatr. Res. 41, 505-512 (1997).
4. Haase, E., et al. Resuscitation with 100% oxygen causes intestinal glutathione oxidation and reoxygenation injury in asphyxiated newborn piglets. Ann. Surg. 240, 364-373 (2004).
5. Stevens, J., et al. Resuscitation with 21% or 100% oxygen is equally effective in restoring perfusion and oxygen metabolism in hypoxic newborn piglet liver. Shock. 27, 657-662 (2007).
6. Johnson, S.T., et al. N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen. Shock. 28, 484-490 (2007).
7. Chapados, I., et al. Plasma cortisol response to ACTH challenge in hypoxic newborn piglets resuscitated with 21% and 100% oxygen. Shock. 33, 519-525 (2010).
8. Cheung, P.Y., et al. Platelet dysfunction in asphyxiated newborn piglets resuscitated with 21% and 100% oxygen. Pediatr. Res. 59, 636-640 (2006).
9. Martin-Ancel, A., et al. Multiple organ involvement in perinatal asphyxia. J. Pediatr. 127, 786-793 (1995)
10. Swindle, M.M. & Smith, A.C. Comparative anatomy and physiology of the pig. Scan. J. Lab. Anim. Sci. Suppl. 25 (Supp 1), 11-22 (1998).
11. Chapados, I. & Cheung, P.Y. Not all models are created equal: Animal models to study hypoxic-ischemic encephalopathy of the newborn. Neonatology. 94, 300-303 (2008).
12. Liu, J.Q., et al. Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxia-injured newborn pigs. PLoS ONE. 5, e15322 (2010).
13. Cheung, P.Y., et al. Cardio-renal recovery of hypoxic newborn pigs after 18%, 21% and 100% reoxygenation. Intensive Care Med. 34, 1114-1121 (2008).
14. Temesvari, P., et al. Modulation of the blood-brain barrier permeability in neonatal cytotoxic brain edema: laboratory and morphological findings obtained on newborn piglets with experimental pneumothorax. Biol. Neonate. 46, 198-208 (1984).
15. Domoki, F., et al. Reventilation with room air or 100% oxygen after asphyxia differentially affects cerebral neuropathology in newborn pigs. Acta. Paediatr. 95, 1109-1115 (2006).
16. Part 15: Neonatal resuscitation: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 122, S909-919 (2010).