Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 13, 2013, Pages 3831-3838

  Eguchi, Keisuke ^a   Fujiwara, Yukio ^b   Hayashida, Akinori ^a   Horlad, Hasita ^b   Kato, Hikaru ^a   Rotinsulu, Henki ^c   Losung, Fitje ^d   Mangindaan, Remy E P ^d   De Voogd, Nicole J ^e   Takeya, Motohiro ^b   Tsukamoto, Sachiko ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c Faculty of Agriculture   (Indonesia)

^d SAM RATULANGI UNIVERSITY   (Indonesia)

^e NATURALIS BIODIVERSITY CENTER   (Netherlands)

Author keywords

Alkaloid; Atherosclerosis; Hyperlipidemia; Manzamine

Indexed keywords

ACYL COA CHOLESTEROL ACYLTRANSFERASE 1; ACYL COA CHOLESTEROL ACYLTRANSFERASE 2; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANZAMINE A; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ACETYL-LDL; ALKALOID; CARBAZOLE DERIVATIVE; LOW DENSITY LIPOPROTEIN; STEROL O-ACYLTRANSFERASE 1; STEROL O-ACYLTRANSFERASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SINUS; ARTICLE; ATHEROSCLEROSIS; CHO CELL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FOAM CELL; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IC 50; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HAMSTER; HYPERLIPIDEMIAS; ISOLATION AND PURIFICATION; METABOLISM; SPONGE (PORIFERA);

ACANTHOSTRONGYLOPHORA INGENS; CRICETULUS GRISEUS; MUS;

ALKALOIDS; ANIMALS; ATHEROSCLEROSIS; CARBAZOLES; CELLS, CULTURED; CHO CELLS; CHOLESTEROL; CHOLESTEROL ESTERS; CRICETINAE; CRICETULUS; FOAM CELLS; HUMANS; HYPERLIPIDEMIAS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, INBRED C57BL; PORIFERA; STEROL O-ACYLTRANSFERASE;

EID: 84878561608     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.025     Document Type: Article

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