New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3512-3517

  Yousaf, Muhammad ^a   Hammond, Nicholas L ^a   Peng, Jiangnan ^a   Wahyuono, Subagus ^b   McIntosh, Kylie A ^c   Charman, William N ^c   Mayer, Alejandro M S ^d   Hamann, Mark T ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b GADJAH MADA UNIVERSITY   (Indonesia)

^c MONASH UNIVERSITY   (Australia)

^d MIDWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12,28 OXA 8 HYDROXYMANZAMINE A; 12,28 OXAMANZAMINE A; 31 KETO 12,34 OXA 32,33 DIHYDROIRCINAL A; ALKALOID DERIVATIVE; CARBON; MANZAMINE A; MANZAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLAMMATORY DISEASE; MALE; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPPORTUNISTIC INFECTION; RAT; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-HIV AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIFUNGAL AGENTS; BIOLOGICAL AVAILABILITY; CARBAZOLES; CARBOLINES; FOURIER ANALYSIS; HIV-1; INDOLES; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PORIFERA; PYRROLES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042643058     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030475b     Document Type: Article

References (13)

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