Hyperbranched polyglycerol is an efficacious and biocompatible novel osmotic agent in a rodent model of peritoneal dialysis

Peritoneal Dialysis International

Volumn 33, Issue 1, 2013, Pages 15-27

  Mendelson, Asher A ^a   Guan, Qiunong ^a   Chafeeva, Irina ^a   da Roza, Gerald A ^a   Kizhakkedathu, Jayachandran N ^a   Du, Caigan ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER COASTAL HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Biocompatibility; Hyperbranched polyglycerol; Peritoneal dialysis solution; Preclinical study

Indexed keywords

CASPASE 3; CELL SURFACE PROTEIN; DIANEAL; GLUCOSE; HUMAN BONE MARROW ENDOTHELIAL PROTEIN 1; HYPERBRANCHED POLYGLYCEROL; OSMOTIC AGENT; PERITONEAL DIALYSIS FLUID; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CELL SURVIVAL; CELL VACUOLE; CELL VIABILITY; CHEMICAL STRUCTURE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYTOTOXICITY; DIALYSATE; EXPERIMENTAL MODEL; FLOW CYTOMETRY; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CLEARANCE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OSMOLARITY; PERITONEAL BIOPSY; PERITONEAL DIALYSIS; PERITONEAL DISEASE; PH; PLASMA; PRIORITY JOURNAL; RAT; ULTRAFILTRATION;

ANIMALS; ASCITIC FLUID; BIOCOMPATIBLE MATERIALS; CELLS, CULTURED; DIALYSIS SOLUTIONS; DISEASE MODELS, ANIMAL; EPITHELIUM; FLOW CYTOMETRY; GLYCEROL; HUMANS; MALE; MATERIALS TESTING; OSMOSIS; PERITONEAL CAVITY; PERITONEAL DIALYSIS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84878553471     PISSN: 08968608     EISSN: 17184304     Source Type: Journal    
DOI: 10.3747/pdi.2012.00148     Document Type: Article

References (55)

1. Vonesh EF, Snyder JJ, Foley RN, Collins AJ. Mortality studies comparing peritoneal dialysis and hemodialysis: what do they tell us? Kidney Int Suppl 2006; (103):S3-11.
2. Moist LM, Port FK, Orzol SM, Young EW, Ostbye T, Wolfe RA, et al. Predictors of loss of residual renal function among new dialysis patients. J Am Soc Nephrol 2000; 11:556-64.
3. Goldfarb-Rumyantzev AS, Hurdle JF, Scandling JD, Baird BC, Cheung AK. The role of pretransplantation renal replacement therapy modality in kidney allograft and recipient survival. Am J Kidney Dis 2005; 46:537-49.
4. Merkus MP, Jager KJ, Dekker FW, Boeschoten EW, Stevens P, Krediet RT. Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The NECOSAD Study Group. Am J Kidney Dis 1997; 29:584-92.
5. Grassmann A, Gioberge S, Moeller S, Brown G. ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends. Nephrol Dial Transplant 2005; 20:2587-93.
6. Fortes PC, de Moraes TP, Mendes JG, Stinghen AE, Ribeiro SC, Pecoits-Filho R. Insulin resistance and glucose homeostasis in peritoneal dialysis. Perit Dial Int 2009; 29(Suppl 2):S145-8.
7. Perl J, Nessim SJ, Bargman JM. The biocompatibility of neutral pH, low-GDP peritoneal dialysis solutions: benefit at bench, bedside, or both? Kidney Int 2011; 79:814-24.
8. Saxena R. Pathogenesis and treatment of peritoneal membrane failure. Pediatr Nephrol 2008; 23:695-703.
9. Davies SJ, Mushahar L, Yu Z, Lambie M. Determinants of peritoneal membrane function over time. Semin Nephrol 2011; 31:172-82.
10. Sunder A, Hanselmann R, Frey H, Mülhaupt R. Controlled synthesis of hyperbranched polyglycerols by ring-opening multibranching polymerization. Macromolecules 1999; 32:4240-6.
11. Wilms D, Stiriba SE, Frey H. Hyperbranched polyglycerols: from the controlled synthesis of biocompatible polyether polyols to multipurpose applications. Acc Chem Res 2010; 43:129-41.
12. Calderón M, Quadir MA, Sharma SK, Haag R. Dendritic polyglycerols for biomedical applications. Adv Mater 2010; 22:190-218.
13. Kainthan RK, Muliawan EB, Hatzikiriakos SG, Brooks DE. Synthesis, characterization, and viscoelastic properties of high molecular weight hyperbranched polyglycerols. Macromolecules 2006; 39:7708-17.
14. Kainthan RK, Janzen J, Kizhakkedathu JN, Devine DV, Brooks DE. Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute. Biomaterials 2008; 29:1693-704.
15. Kainthan RK, Gnanamani M, Ganguli M, Ghosh T, Brooks DE, Maiti S, et al. Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA. Biomaterials 2006; 27:5377-90.
16. Chapanian R, Constantinescu I, Brooks DE, Scott MD, Kizhakkedathu JN. In vivo circulation, clearance, and biodistribution of polyglycerol grafted functional red blood cells. Biomaterials 2012; 33:3047-57.
17. Rossi NA, Constantinescu I, Kainthan RK, Brooks DE, Scott MD, Kizhakkedathu JN. Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols. Biomaterials 2010; 31:4167-78.
18. Kainthan RK, Brooks DE. In vivo biological evaluation of high molecular weight hyperbranched polyglycerols. Biomaterials 2007; 28:4779-87.
19. Du C, Guan Q, Diao H, Yin Z, Jevnikar AM. Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8. Am JPhysiol Renal Physiol 2006; 290:F1044-54.
20. Slater ND, Cope GH, Raftery AT. Peritoneal ultrafiltration after chronic exposure to dialysis fluid. Perit Dial Int 1992; 12:48-50.
21. Wang T, Heimbürger O, Cheng H, Waniewski J, Bergström J, Lindholm B. Effect of increased dialysate fill volume on peritoneal fluid and solute transport. Kidney Int 1997; 52:1068-76.
22. Li W, Chung SC. Flow cytometric evaluation of leukocyte function in rat whole blood. In Vitro Cell Dev Biol Anim 2003; 39:413-19.
23. Yung S, Chan TM. Mesothelial cells. Perit Dial Int 2007; 27(Suppl 2):S110-15.
24. Boehm M, Bergmeister H, Kratochwill K, Vargha R, Lederhuber H, Aufricht C. Cellular stress-response modulators in the acute rat model of peritoneal dialysis. Pediatr Nephrol 2010; 25:169-72.
25. Endemann M, Bergmeister H, Bidmon B, Boehm M, Csaicsich D, Malaga-Dieguez L, et al. Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis. Am JPhysiol Renal Physiol 2007; 292:F47-56.
26. Krediet RT, Lindholm B, Rippe B. Pathophysiology of peritoneal membrane failure. Perit Dial Int 2000; 20(Suppl 4):S22-42.
27. Fetsch PA, Simsir A, Abati A. Comparison of antibodies to HBME-1 and calretinin for the detection of mesothelial cells in effusion cytology. Diagn Cytopathol 2001; 25:158-61.
28. Miettinen M, Kovatich AJ. HBME-1: a monoclonal-antibody useful in the differential-diagnosis of mesothelioma, adenocarcinoma, and soft-tissue and bone tumors. Appl Immunohistochem 1995; 3:115-22.
29. Bender TO, Böhm M, Kratochwill K, Lederhuber H, Endemann M, Bidmon B, et al. HSP-Mediated cytoprotection of mesothelial cells in experimental acute peritoneal dialysis. Perit Dial Int 2010; 30:294-9.
30. Barron WM, Dürr JA, Schrier RW, Lindheimer MD. Role of hemodynamic factors in osmoregulatory alterations of rat pregnancy. Am JPhysiol 1989; 257:R909-16.
31. Krediet RT. Peritoneal physiology-impact on solute and fluid clearance. Adv Ren Replace Ther 2000; 7:271-9.
32. Krediet RT, Zuyderhoudt FM, Boeschoten EW, Arisz L. Alterations in the peritoneal transport of water and solutes during peritonitis in continuous ambulatory peritoneal dialysis patients. Eur JClin Invest 1987; 17:43-52.
33. Combet S, Van Landschoot M, Moulin P, Piech A, Verbavatz JM, Goffin E, et al. Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis. JAm Soc Nephrol 1999; 10:2185-96.
34. Rippe B. How to assess transport in animals? Perit Dial Int 2009; 29(Suppl 2):S32-5.
35. Ha H, Yu MR, Choi HN, Cha MK, Kang HS, Kim MH, et al. Effects of conventional and new peritoneal dialysis solutions on human peritoneal mesothelial cell viability and proliferation. Perit Dial Int 2000; 20(Suppl 5):S10-18.
36. Tzamaloukas AH. Peritoneal toxicities of hypertonic dextrose dialysate. Adv Perit Dial 1999; 15:217-21.
37. Manuprasert W, Kanchanabuch S, Eiam-Ong S, Kanjanabuch T. The in vitro toxicity of peritoneal dialysis fluid. JMed Assoc Thai 2011; 94(Suppl 4):S140-7.
38. Boulanger E, Wautier MP, Gane P, Mariette C, Devuyst O, Wautier JL. The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products. Nephrol Dial Transplant 2004; 19:2208-16.
39. Gastaldello K, Husson C, Dondeyne JP, Vanherweghem JL, Tielemans C. Cytotoxicity of mononuclear cells as induced by peritoneal dialysis fluids: insight into mechanisms that regulate osmotic stress-related apoptosis. Perit Dial Int 2008; 28:655-66.
40. Ogata S, Naito T, Yorioka N, Kiribayashi K, Kuratsune M, Kohno N. Effect of lactate and bicarbonate on human peritoneal mesothelial cells, fibroblasts and vascular endothelial cells, and the role of basic fibroblast growth factor. Nephrol Dial Transplant 2004; 19:2831-7.
41. Gotloib L, Wajsbrot V, Cuperman Y, Shostak A. Acute oxidative stress induces peritoneal hyperpermeability, mesothelial loss, and fibrosis. JLab Clin Med 2004; 143:31-40.
42. Breborowicz A, Rodela H, Oreopoulos DG. Toxicity of osmotic solutes on human mesothelial cells in vitro. Kidney Int 1992; 41:1280-5.
43. Witowski J, Korybalska K, Ksiazek K, Wisniewska-Elnur J, Jörres A, Lage C, et al. Peritoneal dialysis with solutions low in glucose degradation products is associated with improved biocompatibility profile towards peritoneal mesothelial cells. Nephrol Dial Transplant 2004; 19:917-24.
44. Lee DH, Choi SY, Ryu HM, Kim CD, Park SH, Chung HY, et al. 3,4-Dideoxyglucosone-3-ene induces apoptosis in human peritoneal mesothelial cells. Perit Dial Int 2009; 29:44-51. [Erratum in: Perit Dial Int 2009; 29:132]
45. Morgan LW, Wieslander A, Davies M, Horiuchi T, Ohta Y, Beavis MJ, et al. Glucose degradation products (GDP) retard remesothelialization independently of d-glucose concentration. Kidney Int 2003; 64:1854-66.
46. Henics T, Wheatley DN. Cytoplasmic vacuolation, adaptation and cell death: a view on new perspectives and features. Biol Cell 1999; 91:485-98.
47. Gotloib L. Mechanisms of cell death during peritoneal dialysis. A role for osmotic and oxidative stress. Contrib Nephrol 2009; 163:35-44.
48. Ferguson TA, Choi J, Green DR. Armed response: how dying cells influence T-cell functions. Immunol Rev 2011; 241:77-88.
49. Krysko DV, D'Herde K, Vandenabeele P. Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 2006; 11:1709-26.
50. Nakao A, Nakao K, Takatori Y, Kojo S, Inoue J, Akagi S, et al. Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy. Nephrol Dial Transplant 2010; 25:1479-88.
51. Selgas R, Bajo A, Jiménez-Heffernan JA, Sánchez-Tomero JA, Del Peso G, Aguilera A, et al. Epithelial-to-mesenchymal transition of the mesothelial cell-its role in the response of the peritoneum to dialysis. Nephrol Dial Transplant 2006; 21(Suppl 2):ii2-7.
52. Vrtovsnik F, Coester AM, Lopes-Barreto D, de Waart DR, Van der Wal AC, Struijk DG, et al. Induction of chronic kidney failure in a long-term peritoneal exposure model in the rat: effects on functional and structural peritoneal alterations. Perit Dial Int 2010; 30:558-69.
53. Bender TO, Witowski J, Ksiazek K, Jörres A. Comparison of icodextrin- and glucose-based peritoneal dialysis fluids in their acute and chronic effects on human peritoneal mesothelial cells. Int JArtif Organs 2007; 30:1075-82.
54. Witowski J, Wisniewska J, Korybalska K, Bender TO, Breborowicz A, Gahl GM, et al. Prolonged exposure to glucose degradation products impairs viability and function of human peritoneal mesothelial cells. JAm Soc Nephrol 2001; 12:2434-41.
55. Zareie M, Keuning ED, ter Wee PM, Schalkwijk CG, Beelen RH, van den Born J. Improved biocompatibility of bicarbonate/lactate-buffered PDF is not related to pH. Nephrol Dial Transplant 2006; 21:208-16.