Octreotide-mediated tumor cell uptake and intracellular pH-responsive drug delivery of the self-assembly supramolecular nanocarrier

Journal of Drug Targeting

Volumn 21, Issue 5, 2013, Pages 415-426

  Niu, Jiangxiu ^a,b   Huang, Aiwen ^a,c   Xiao, Yanyu ^a   Su, Zhigui ^a   Li, Hongying ^a   Ping, Qineng ^a   Bao, Xiao ^a   Li, Sai ^a   Chen, Yinan ^a   Sun, Mingjie ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HUANGSHAN UNIVERSITY   (China)

^c FUZHOU GENERAL HOSPITAL   (China)

Author keywords

Animal experiments; Cellular uptake; Octreotide; PH triggered release; SSTR mediated endocytosis; Supramolecular nanocarrier

Indexed keywords

CHITOSAN DERIVATIVE; DOXORUBICIN; MACROGOL STEARATE; NANOCARRIER; OCTREOTIDE; SOMATOSTATIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CELL NUCLEUS; CELL PH; CIRCULATION TIME; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA; SURVIVAL TIME; TUMOR CELL; TUMOR GROWTH; WEIGHT CHANGE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER NEOPLASMS; MICE; NANOPARTICLES; OCTREOTIDE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; TISSUE DISTRIBUTION;

EID: 84878547697     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2012.757771     Document Type: Article

References (42)

1. Karathanasis E, Chan L, Balusu SR, et al. Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. Biomaterials 2008;29: 4815-22.
2. Gao Y, Gu W, Chen L, et al. A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection. J Control Release 2007;118:381-8.
3. Wan F, You J, Sun Y, et al. Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro. Int J Pharm 2008;359:104-10.
4. Guo M, Que C, Wang C, et al. Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery. Biomaterials 2011;32: 185-94.
5. Hong M, Zhu S, Jiang Y, et al. Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin- PEG-nanoparticles. J Control Release 2010;141:22-9.
6. Bae Y, Kataoka K. Significant enhancement of antitumor activity and bioavailability of intracellular pH-sensitive polymeric micelles by folate conjugation. J Control Release 2006;116:e49-50.
7. Gao ZG, Lee DH, Kim DI, Bae YH. Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice. J Drug Target 2005;13:391-7.
8. Lehn JM. Toward self-organization and complex matter. Science 2002;295:2400-03.
9. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001;47:113-31.
10. Satoh T, Higuchi Y, Kawakami S, et al. Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control. J Control Release 2009;136:187-95.
11. Bae Y, Fukushima S, Harada A, Kataoka K. Design of environment- sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Engl 2003;42:4640-3.
12. Bae Y, Nishiyama N, Fukushima S, et al. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 2005b;16:122-30.
13. Capurso G, Panzuto F, Delle Fave G. Clinical relevance of the expression of somatostatin receptors in digestive endocrine tumours. Dig Liver Dis 2010;42:173-4.
14. Hillel PG, van Beek EJ, Taylor C, et al. The clinical impact of a combined gamma camera/CT imaging system on somatostatin receptor imaging of neuroendocrine tumours. Clin Radiol 2006;61:579-87.
15. Watt HL, Kharmate G, Kumar U. Biology of somatostatin in breast cancer. Mol Cell Endocrinol 2008;286:251-61.
16. Na DH, Murty SB, Lee KC, et al. Preparation and stability of poly (ethylene glycol) (PEG)ylated octreotide for application to microsphere delivery. AAPS Pharm Sci Tech 2003;4:E72.
17. Olson BJ, Markwell J. Assays for determination of protein concentration. Curr Protoc Protein Sci 2007;Chapter 3:Unit 3.4.
18. Wang CH, Hsiue GH. Polymeric micelles with a pH-responsive structure as intracellular drug carriers. J Control Release 2005;108:140-9.
19. Speelmans G, Staffhorst RW, de Kruijff B, de Wolf FA. Transport studies of doxorubicin in model membranes indicate a difference in passive diffusion across and binding at the outer and inner leaflets of the plasma membrane. Biochemistry 1994;33:13761-8.
20. Yoo HS, Park TG. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Release 2001;70:63-70.
21. Hovorka O, St'astny M, Etrych T, et al. Differences in the intracellular fate of free and polymer-bound doxorubicin. J Control Release 2002;80:101-17.
22. Awasthi VD, Garcia D, Goins BA, Phillips WT. Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits. Int J Pharm 2003;253:121-32.
23. Sheng Y, Liu C, Yuan Y, et al. Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and watersoluble chitosan. Biomaterials 2009;30:2340-8.
24. Kajiwara E, Kawano K, Hattori Y, et al. Long-circulating liposomeencapsulated ganciclovir enhances the efficacy of HSV-TK suicide gene therapy. J Control Release 2007;120:104-10.
25. Shao K, Huang R, Li J, et al. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J Control Release 2010;147:118-26.
26. Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim Biophys Acta 2009;1788:2259-66.
27. Kulaksiz H, Eissele R, Rossler D, et al. Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies. Gut 2002;50:52-60.
28. Singh V, Brendel MD, Zacharias S, et al. Characterization of somatostatin receptor subtype-specific regulation of insulin and glucagon secretion: an in vitro study on isolated human pancreatic islets. J Clin Endocrinol Metab 2007;92:673-80.
29. Wu JX, Yuan YZ, Xu JY, et al. Changes in somatostatin receptor expression of the pancreas and effectiveness of octreotide in rats with acute necrotizing pancreatitis. Chin J Dig Dis 2004;5:35-9.
30. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001;41:189-207.
31. Caliceti P, Veronese FM. Pharmacokinetic and biodistribution properties of poly (ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 2003;55:1261-77.
32. Rossi J, Giasson S, Khalid MN, et al. Long-circulating poly (ethylene glycol)-coated emulsions to target solid tumors. Eur J Pharm Biopharm 2007;67:329-38.
33. Fang J, Sawa T, Maeda H. Factors and mechanism of ''EPR'' effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv Exp Med Biol 2003;519:29-49.
34. Han HD, Lee A, Song CK, et al. In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes. Int J Pharm 2006;313:181-8.
35. MacEwan SR, Callahan DJ, Chilkoti A. Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. Nanomedicine (Lond) 2010;5:793-806.
36. Yoo HS, Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 2004;96:273-83.
37. Lee ES, Na K, Bae YH. Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. J Control Release 2005;103:405-18.
38. Bae Y, Jang WD, Nishiyama N, et al. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pHtriggered drug releasing properties for active intracellular drug delivery. Mol Biosyst 2005;1:242-50.
39. Ko J, Park K, Kim YS, et al. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly (beta-amino ester) block copolymer micelles for cancer therapy. J Control Release 2007;123:109-15.
40. Park S, Yoo HS. In vivo and in vitro anti-cancer activities and enhanced cellular uptakes of EGF fragment decorated doxorubicin nano-aggregates. Int J Pharm 2010;383:178-85.
41. Di Donato A, Ghiggeri GM, Di Duca M, et al. Lysyl oxidase expression and collagen cross-linking during chronic adriamycin nephropathy. Nephron 1997;76:192-200.
42. Zeidan Q, Strauss M, Porras N, Anselmi G. Differential longterm subcellular responses in heart and liver to adriamycin stress. Exogenous L-carnitine cardiac and hepatic protection. J Submicrosc Cytol Pathol 2002;34:315-21.