Differential long-term subcellular responses in heart and liver to adriamycin stress. Exogenous L-carnitine cardiac and hepatic protection

Journal of Submicroscopic Cytology and Pathology

Volumn 34, Issue 3, 2002, Pages 315-321

  Zeidan Q ^a   Strauss, M ^a   Porras, N ^a   Anselmi, G ^a  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Adriamycin toxic stress; Heart; L carnitine; Liver; Subcellular damage

Indexed keywords

CARNITINE; DOXORUBICIN; LIPID; ANTINEOPLASTIC AGENT; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY WEIGHT; CELL ACTIVITY; CELL DAMAGE; CELL DISRUPTION; CELL ULTRASTRUCTURE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLOGY; CYTOPLASM VESICLE; FEMALE; GENETIC POLYMORPHISM; HEART PROTECTION; INJECTION; INTERMETHOD COMPARISON; LIVER; LIVER PROTECTION; MITOCHONDRION SWELLING; MUSCLE FIBRIL; NONHUMAN; RANDOMIZATION; RAT; STRESS; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CARDIOMYOPATHY; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; DRUG EFFECT; HEART; HEART MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; LIPID METABOLISM; LIVER DISEASE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALIA;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOMYOPATHIES; CARNITINE; DOXORUBICIN; DRUG THERAPY, COMBINATION; FEMALE; HEART; INJECTIONS, INTRAVENOUS; LIPID METABOLISM; LIVER; LIVER DISEASES; MITOCHONDRIAL SWELLING; MYOCARDIUM; MYOFIBRILS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; VACUOLES;

EID: 0036652156     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. AVILES A., HERRERA J., RAMOS E., AMBRIZ R., AGUIRRE J. and PIZZUTO J., 1984. Hepatic injury during doxorubicin therapy. Arch. Pathol. Lab. Med., 108, 912-913.
2. BATTELLI D., BELLEI M., ARRIGONI-MARTELLI E., MUSCATELLO U. and BOBYLEVA V., 1992. Interaction of carnitine with mitochondrial cardiolipin. Biochim. Biophys. Acta, 1117, 33-36.
3. BEANLANDS R.S.B., SHAIKH N.A., WEN W.H., DAWOOD F., UGNAT A.M., MCLAUGHLIN P.R., CARERE R. and LIU P.P., 1994. Alterations in fatty acid metabolism in adriamycin cardiomyopathy. J. Mol. Cell. Cardiol., 26, 109-119.
4. BECK S.C, PAIDAS C.N., TAN H., YANG J. and DE MAIO A., 1995. Depressed expression of the inducible form of hsp-70 (hsp-72) in brain and heart following in-vivo heat shock. Am. J. Physiol., 269, R608-R613.
5. BIEBER L.L., 1988. Carnitine. Ann. Rev. Biochem., 57, 261-283.
6. CHANDA S. and MEHENDALE H.M., 1996. Role of nutrition in the survival after hepatotoxic injury. Toxicology, 111, 163-178.
7. CLOUET P., SEMPORÉ G., TSOKO M., GRESTI J., DEMARQUOY J., NIOT I., BÉZARD J. and MARTIN-PRIVAT P., 1996. Effect of short- and long-term treatments by a low level of dietary L-carnitine on parameters related to fatty acid oxidation in Wistar rat. Biochim. Biophys. Acta, 1299, 191-197.
8. DOROSHOW J.H., LOCKER G.Y. and MYERS C.E., 1980. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J. Clin. Invest., 65, 128-135.
9. FOULIS P.R., HYLAND S.B. and GOTTFRIED M., 1988. Drug induced morphologic changes in the liver. Ann. Clin. Lab. Sci., 18, 215-228.
10. FU L.X., WAAGSTEIN F. and HJALMARSON A., 1990. A new insight into adriamycin-induced cardiotoxicity. Intern. J. Cardiol., 29, 15-20.
11. MARTUCCI D.C.A., LÓPEZ P.R. and DORDOVEZ G., 1992. Efecto hepatoprotector de la L-carnitina en ratas ayunadas (Effect of L-carnitine on rat hepatocytes by partial starvation). 1er Congreso Atlántico de Microscopía Electrónica. V Jornadas Venezolanas de Microscopía Electrónica.
12. NEELY J. and MORGAN H., 1974. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu. Rev. Physiol., 36, 413-459.
13. NERI B., CINI-NERI G., BARTALUCCI S. and BANDINELLI M., 1986. Protective effect of L-carnitine on cardiac metabolic damage induced by doxorubicin in vitro. Anticancer Res., 6, 659-662.
14. ODOM A.L., HATWIG C.A., STANLEY J.S. and BENSON A.M., 1992. Biochemical determinants of adriamycin toxicity in mouse liver, heart and intestine. Biochem. Pharmacol., 43, 831-836.
15. PALMEIRA C.M., SERRANO J., KUEHL D.W. and WALLACE K.B., 1997. Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin. Biochim. Biophys. Acta, 1321, 101-106.
16. PAULSON D.J., 1998. Carnitine deficiency-induced cardiomyopathy. Mol. Cell. Biochem., 180, 33-41.
17. REGITZ V., SHUG A. and FLECK E., 1990. Defective myocardial carnitine metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary, hypertensive and valvular heart diseases. Am. J. Cardiol., 65, 755-760.
18. SHAN K., LINCOFF A.M. and YOUNG J.B., 1996. Anthracycline-induced cardiotoxicity. Ann. Intern. Med., 125, 47-58.
19. SINGAL P.K., LI T., KUMAR D., DANELISEN I. and ILISKOVIC N., 2000. Adriamycin-induced heart failure: mechanism and modulation. Mol Cell. Biochem., 207, 77-85.
20. STRAUSS M., ANSELMI G., HERMOSO T. and TEJERO F., 1998. Carnitine promotes heat shock protein synthesis in adriamycin-induced cardiomyopathy in a neonatal rat experimental model. J. Mol. Cell. Cardiol., 30, 2319-2325.