-
1
-
-
57549112904
-
An experimental and computational study of effects of microtubule stabilization on T-cell polarity
-
Baratt A., Arkhipov S.N., Maly I.V. An experimental and computational study of effects of microtubule stabilization on T-cell polarity. PLoS One 2008, 3:e3861.
-
(2008)
PLoS One
, vol.3
-
-
Baratt, A.1
Arkhipov, S.N.2
Maly, I.V.3
-
2
-
-
22244473991
-
A microtubule-dependent zone of active RhoA during cleavage plane specification
-
Bement W.M., Benink H.A., von Dassow G. A microtubule-dependent zone of active RhoA during cleavage plane specification. J.Cell Biol. 2005, 170:91-101.
-
(2005)
J.Cell Biol.
, vol.170
, pp. 91-101
-
-
Bement, W.M.1
Benink, H.A.2
von Dassow, G.3
-
3
-
-
0014385564
-
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
-
Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest. Suppl. 1968, 97:77-89.
-
(1968)
Scand. J. Clin. Lab. Invest. Suppl.
, vol.97
, pp. 77-89
-
-
Böyum, A.1
-
4
-
-
70350336588
-
Architecture-dependent noise discriminates functionally analogous differentiation circuits
-
Caǧatay T., Turcotte M., Elowitz M.B., Garcia-Ojalvo J., Süel G.M. Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell 2009, 139:512-522.
-
(2009)
Cell
, vol.139
, pp. 512-522
-
-
Caǧatay, T.1
Turcotte, M.2
Elowitz, M.B.3
Garcia-Ojalvo, J.4
Süel, G.M.5
-
5
-
-
84867581908
-
Designing synthetic regulatory networks capable of self-organizing cell polarization
-
Chau A.H., Walter J.M., Gerardin J., Tang C., Lim W.A. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell 2012, 151:320-332.
-
(2012)
Cell
, vol.151
, pp. 320-332
-
-
Chau, A.H.1
Walter, J.M.2
Gerardin, J.3
Tang, C.4
Lim, W.A.5
-
6
-
-
79951847975
-
Theoretical modeling of aging effects in microtubule dynamics
-
Ebbinghaus M., Santen L. Theoretical modeling of aging effects in microtubule dynamics. Biophys. J. 2011, 100:832-838.
-
(2011)
Biophys. J.
, vol.100
, pp. 832-838
-
-
Ebbinghaus, M.1
Santen, L.2
-
7
-
-
0036915826
-
Microtubule asymmetry during neutrophil polarization and migration
-
Eddy R.J., Pierini L.M., Maxfield F.R. Microtubule asymmetry during neutrophil polarization and migration. Mol. Biol. Cell 2002, 13:4470-4483.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 4470-4483
-
-
Eddy, R.J.1
Pierini, L.M.2
Maxfield, F.R.3
-
8
-
-
0000395930
-
Stochastic dynamics of microtubules: a model for caps and catastrophes
-
Flyvbjerg H., Holy T.E., Leibler S. Stochastic dynamics of microtubules: a model for caps and catastrophes. Phys. Rev. Lett. 1994, 73:2372-2375.
-
(1994)
Phys. Rev. Lett.
, vol.73
, pp. 2372-2375
-
-
Flyvbjerg, H.1
Holy, T.E.2
Leibler, S.3
-
9
-
-
28044473385
-
Diffusion-limited phase separation in eukaryotic chemotaxis
-
Gamba A., de Candia A., Di Talia S., Coniglio A., Bussolino F., Serini G. Diffusion-limited phase separation in eukaryotic chemotaxis. Proc. Natl. Acad. Sci. USA 2005, 102:16927-16932.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 16927-16932
-
-
Gamba, A.1
de Candia, A.2
Di Talia, S.3
Coniglio, A.4
Bussolino, F.5
Serini, G.6
-
10
-
-
84860267047
-
A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation
-
Gay G., Courtheoux T., Reyes C., Tournier S., Gachet Y. A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation. J.Cell Biol. 2012, 196:757-774.
-
(2012)
J.Cell Biol.
, vol.196
, pp. 757-774
-
-
Gay, G.1
Courtheoux, T.2
Reyes, C.3
Tournier, S.4
Gachet, Y.5
-
11
-
-
33745451921
-
Oscillations and variability in the p53 system
-
2006.0033
-
Geva-Zatorsky N., Rosenfeld N., Itzkovitz S., Milo R., Sigal A., Dekel E., Yarnitzky T., Liron Y., Polak P., Lahav G., Alon U. Oscillations and variability in the p53 system. Mol. Syst. Biol. 2006, 2. 2006.0033.
-
(2006)
Mol. Syst. Biol.
, vol.2
-
-
Geva-Zatorsky, N.1
Rosenfeld, N.2
Itzkovitz, S.3
Milo, R.4
Sigal, A.5
Dekel, E.6
Yarnitzky, T.7
Liron, Y.8
Polak, P.9
Lahav, G.10
Alon, U.11
-
12
-
-
68049142313
-
Adaptive-control model for neutrophil orientation in the direction of chemical gradients
-
Irimia D., Balázsi G., Agrawal N., Toner M. Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys. J. 2009, 96:3897-3916.
-
(2009)
Biophys. J.
, vol.96
, pp. 3897-3916
-
-
Irimia, D.1
Balázsi, G.2
Agrawal, N.3
Toner, M.4
-
13
-
-
77951643590
-
Identifying single-cell molecular programs by stochastic profiling
-
Janes K.A., Wang C.C., Holmberg K.J., Cabral K., Brugge J.S. Identifying single-cell molecular programs by stochastic profiling. Nat. Methods 2010, 7:311-317.
-
(2010)
Nat. Methods
, vol.7
, pp. 311-317
-
-
Janes, K.A.1
Wang, C.C.2
Holmberg, K.J.3
Cabral, K.4
Brugge, J.S.5
-
14
-
-
34547699211
-
Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk
-
Jilkine A., Marée A.F., Edelstein-Keshet L. Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bull. Math. Biol. 2007, 69:1943-1978.
-
(2007)
Bull. Math. Biol.
, vol.69
, pp. 1943-1978
-
-
Jilkine, A.1
Marée, A.F.2
Edelstein-Keshet, L.3
-
15
-
-
44349186015
-
Mechanism of shape determination in motile cells
-
Keren K., Pincus Z., Allen G.M., Barnhart E.L., Marriott G., Mogilner A., Theriot J.A. Mechanism of shape determination in motile cells. Nature 2008, 453:475-480.
-
(2008)
Nature
, vol.453
, pp. 475-480
-
-
Keren, K.1
Pincus, Z.2
Allen, G.M.3
Barnhart, E.L.4
Marriott, G.5
Mogilner, A.6
Theriot, J.A.7
-
16
-
-
28544450485
-
Design principles of a bacterial signalling network
-
Kollmann M., Løvdok L., Bartholomé K., Timmer J., Sourjik V. Design principles of a bacterial signalling network. Nature 2005, 438:504-507.
-
(2005)
Nature
, vol.438
, pp. 504-507
-
-
Kollmann, M.1
Løvdok, L.2
Bartholomé, K.3
Timmer, J.4
Sourjik, V.5
-
17
-
-
77955223786
-
On identifying information from image-based spatial polarity phenotypes in neutrophils
-
Ku C.J., Wang Y., Pavie B., Altschuler S.J., Wu L.F. On identifying information from image-based spatial polarity phenotypes in neutrophils. Proc. IEEE Int. Symp. Biomed. Imaging 2010, 14-17:1029-1032.
-
(2010)
Proc. IEEE Int. Symp. Biomed. Imaging
, pp. 1029-1032
-
-
Ku, C.J.1
Wang, Y.2
Pavie, B.3
Altschuler, S.J.4
Wu, L.F.5
-
18
-
-
84861552972
-
Network crosstalk dynamically changes during neutrophil polarization
-
Ku C.J., Wang Y., Weiner O.D., Altschuler S.J., Wu L.F. Network crosstalk dynamically changes during neutrophil polarization. Cell 2012, 149:1073-1083.
-
(2012)
Cell
, vol.149
, pp. 1073-1083
-
-
Ku, C.J.1
Wang, Y.2
Weiner, O.D.3
Altschuler, S.J.4
Wu, L.F.5
-
19
-
-
83455164706
-
Temporal competition between differentiation programs determines cell fate choice
-
Kuchina A., Espinar L., Çaǧatay T., Balbin A.O., Zhang F., Alvarado A., Garcia-Ojalvo J., Süel G.M. Temporal competition between differentiation programs determines cell fate choice. Mol. Syst. Biol. 2011, 7:557.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 557
-
-
Kuchina, A.1
Espinar, L.2
Çaǧatay, T.3
Balbin, A.O.4
Zhang, F.5
Alvarado, A.6
Garcia-Ojalvo, J.7
Süel, G.M.8
-
20
-
-
84868535997
-
Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
-
Kumar S., Xu J., Perkins C., Guo F., Snapper S., Finkelman F.D., Zheng Y., Filippi M.D. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood 2012, 120:3563-3574.
-
(2012)
Blood
, vol.120
, pp. 3563-3574
-
-
Kumar, S.1
Xu, J.2
Perkins, C.3
Guo, F.4
Snapper, S.5
Finkelman, F.D.6
Zheng, Y.7
Filippi, M.D.8
-
21
-
-
27744493325
-
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis
-
Kwan K.M., Kirschner M.W. A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development 2005, 132:4599-4610.
-
(2005)
Development
, vol.132
, pp. 4599-4610
-
-
Kwan, K.M.1
Kirschner, M.W.2
-
22
-
-
0036219106
-
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils
-
Levchenko A., Iglesias P.A. Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys. J. 2002, 82:50-63.
-
(2002)
Biophys. J.
, vol.82
, pp. 50-63
-
-
Levchenko, A.1
Iglesias, P.A.2
-
23
-
-
78650739318
-
A computational model predicts Xenopus meiotic spindle organization
-
Loughlin R., Heald R., Nédélec F. A computational model predicts Xenopus meiotic spindle organization. J.Cell Biol. 2010, 191:1239-1249.
-
(2010)
J.Cell Biol.
, vol.191
, pp. 1239-1249
-
-
Loughlin, R.1
Heald, R.2
Nédélec, F.3
-
24
-
-
68749118345
-
Defining network topologies that can achieve biochemical adaptation
-
Ma W., Trusina A., El-Samad H., Lim W.A., Tang C. Defining network topologies that can achieve biochemical adaptation. Cell 2009, 138:760-773.
-
(2009)
Cell
, vol.138
, pp. 760-773
-
-
Ma, W.1
Trusina, A.2
El-Samad, H.3
Lim, W.A.4
Tang, C.5
-
25
-
-
0032823984
-
Orientation of chemotactic cells and growth cones: models and mechanisms
-
Meinhardt H. Orientation of chemotactic cells and growth cones: models and mechanisms. J.Cell Sci. 1999, 112:2867-2874.
-
(1999)
J.Cell Sci.
, vol.112
, pp. 2867-2874
-
-
Meinhardt, H.1
-
26
-
-
0035825193
-
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
-
Michaelson D., Silletti J., Murphy G., D'Eustachio P., Rush M., Philips M.R. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J.Cell Biol. 2001, 152:111-126.
-
(2001)
J.Cell Biol.
, vol.152
, pp. 111-126
-
-
Michaelson, D.1
Silletti, J.2
Murphy, G.3
D'Eustachio, P.4
Rush, M.5
Philips, M.R.6
-
27
-
-
28844495057
-
Dynamic instability of microtubules: effect of catastrophe-suppressing drugs
-
Mishra P.K., Kunwar A., Mukherji S., Chowdhury D. Dynamic instability of microtubules: effect of catastrophe-suppressing drugs. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 2005, 72:051914.
-
(2005)
Phys. Rev. E Stat. Nonlin. Soft Matter Phys.
, vol.72
, pp. 051914
-
-
Mishra, P.K.1
Kunwar, A.2
Mukherji, S.3
Chowdhury, D.4
-
28
-
-
33646764616
-
Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways
-
Narang A. Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways. J.Theor. Biol. 2006, 240:538-553.
-
(2006)
J.Theor. Biol.
, vol.240
, pp. 538-553
-
-
Narang, A.1
-
29
-
-
79958046951
-
Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour
-
Neilson M.P., Veltman D.M., van Haastert P.J., Webb S.D., Mackenzie J.A., Insall R.H. Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. PLoS Biol. 2011, 9:e1000618.
-
(2011)
PLoS Biol.
, vol.9
-
-
Neilson, M.P.1
Veltman, D.M.2
van Haastert, P.J.3
Webb, S.D.4
Mackenzie, J.A.5
Insall, R.H.6
-
30
-
-
56149100878
-
An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning
-
Odell G.M., Foe V.E. An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning. J.Cell Biol. 2008, 183:471-483.
-
(2008)
J.Cell Biol.
, vol.183
, pp. 471-483
-
-
Odell, G.M.1
Foe, V.E.2
-
31
-
-
34047218649
-
A mathematical model for neutrophil gradient sensing and polarization
-
Onsum M., Rao C.V. A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput. Biol. 2007, 3:e36.
-
(2007)
PLoS Comput. Biol.
, vol.3
-
-
Onsum, M.1
Rao, C.V.2
-
32
-
-
34347352254
-
A mass conserved reaction-diffusion system captures properties of cell polarity
-
Otsuji M., Ishihara S., Co C., Kaibuchi K., Mochizuki A., Kuroda S. A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput. Biol. 2007, 3:e108.
-
(2007)
PLoS Comput. Biol.
, vol.3
-
-
Otsuji, M.1
Ishihara, S.2
Co, C.3
Kaibuchi, K.4
Mochizuki, A.5
Kuroda, S.6
-
33
-
-
33750610850
-
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis
-
Pestonjamasp K.N., Forster C., Sun C., Gardiner E.M., Bohl B., Weiner O., Bokoch G.M., Glogauer M. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood 2006, 108:2814-2820.
-
(2006)
Blood
, vol.108
, pp. 2814-2820
-
-
Pestonjamasp, K.N.1
Forster, C.2
Sun, C.3
Gardiner, E.M.4
Bohl, B.5
Weiner, O.6
Bokoch, G.M.7
Glogauer, M.8
-
34
-
-
53549123008
-
Nature, nurture, or chance: stochastic gene expression and its consequences
-
Raj A., van Oudenaarden A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 2008, 135:216-226.
-
(2008)
Cell
, vol.135
, pp. 216-226
-
-
Raj, A.1
van Oudenaarden, A.2
-
35
-
-
84878542719
-
-
ImageJ, U. S. National stitutes of Health, Bethesda, Maryland, USA.
-
Rasband, W.S. (1997-2012). ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA, http://imagej.nih.gov/ij/.
-
(1997)
-
-
Rasband, W.S.1
-
36
-
-
77953287348
-
Mechanistic revisions of phenomenological modeling strategies in molecular evolution
-
Rodrigue N., Philippe H. Mechanistic revisions of phenomenological modeling strategies in molecular evolution. Trends Genet. 2010, 26:248-252.
-
(2010)
Trends Genet.
, vol.26
, pp. 248-252
-
-
Rodrigue, N.1
Philippe, H.2
-
37
-
-
6944252346
-
Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner
-
Rogers S.L., Wiedemann U., Häcker U., Turck C., Vale R.D. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1-dependent manner. Curr. Biol. 2004, 14:1827-1833.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1827-1833
-
-
Rogers, S.L.1
Wiedemann, U.2
Häcker, U.3
Turck, C.4
Vale, R.D.5
-
38
-
-
44349180298
-
Moving towards a better understanding of chemotaxis
-
Stephens L., Milne L., Hawkins P. Moving towards a better understanding of chemotaxis. Curr. Biol. 2008, 18:R485-R494.
-
(2008)
Curr. Biol.
, vol.18
-
-
Stephens, L.1
Milne, L.2
Hawkins, P.3
-
39
-
-
77952911072
-
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
-
Swaney S.F., Huang C.H., Devreotes P.N. Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu. Rev. Biophys. 2010, 39:265-289.
-
(2010)
Annu. Rev. Biophys.
, vol.39
, pp. 265-289
-
-
Swaney, S.F.1
Huang, C.H.2
Devreotes, P.N.3
-
40
-
-
27744548870
-
Mechanochemical model of microtubule structure and self-assembly kinetics
-
VanBuren V., Cassimeris L., Odde D.J. Mechanochemical model of microtubule structure and self-assembly kinetics. Biophys. J. 2005, 89:2911-2926.
-
(2005)
Biophys. J.
, vol.89
, pp. 2911-2926
-
-
VanBuren, V.1
Cassimeris, L.2
Odde, D.J.3
-
41
-
-
33746648129
-
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
-
Van Keymeulen A., Wong K., Knight Z.A., Govaerts C., Hahn K.M., Shokat K.M., Bourne H.R. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J.Cell Biol. 2006, 174:437-445.
-
(2006)
J.Cell Biol.
, vol.174
, pp. 437-445
-
-
Van Keymeulen, A.1
Wong, K.2
Knight, Z.A.3
Govaerts, C.4
Hahn, K.M.5
Shokat, K.M.6
Bourne, H.R.7
-
42
-
-
0034644270
-
The segment polarity network is a robust developmental module
-
von Dassow G., Meir E., Munro E.M., Odell G.M. The segment polarity network is a robust developmental module. Nature 2000, 406:188-192.
-
(2000)
Nature
, vol.406
, pp. 188-192
-
-
von Dassow, G.1
Meir, E.2
Munro, E.M.3
Odell, G.M.4
-
43
-
-
34548703094
-
An actin-based wave generator organizes cell motility
-
Weiner O.D., Marganski W.A., Wu L.F., Altschuler S.J., Kirschner M.W. An actin-based wave generator organizes cell motility. PLoS Biol. 2007, 5:e221.
-
(2007)
PLoS Biol.
, vol.5
-
-
Weiner, O.D.1
Marganski, W.A.2
Wu, L.F.3
Altschuler, S.J.4
Kirschner, M.W.5
-
44
-
-
33644865751
-
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism
-
Wong K., Pertz O., Hahn K., Bourne H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc. Natl. Acad. Sci. USA 2006, 103:3639-3644.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 3639-3644
-
-
Wong, K.1
Pertz, O.2
Hahn, K.3
Bourne, H.4
-
45
-
-
37249022031
-
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
-
Wong K., Van Keymeulen A., Bourne H.R. PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J.Cell Biol. 2007, 179:1141-1148.
-
(2007)
J.Cell Biol.
, vol.179
, pp. 1141-1148
-
-
Wong, K.1
Van Keymeulen, A.2
Bourne, H.R.3
-
46
-
-
78049265815
-
Cells navigate with a local-excitation, global-inhibition-biased excitable network
-
Xiong Y., Huang C.H., Iglesias P.A., Devreotes P.N. Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc. Natl. Acad. Sci. USA 2010, 107:17079-17086.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 17079-17086
-
-
Xiong, Y.1
Huang, C.H.2
Iglesias, P.A.3
Devreotes, P.N.4
-
47
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J., Wang F., Van Keymeulen A., Herzmark P., Straight A., Kelly K., Takuwa Y., Sugimoto N., Mitchison T., Bourne H.R. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003, 114:201-214.
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
Kelly, K.6
Takuwa, Y.7
Sugimoto, N.8
Mitchison, T.9
Bourne, H.R.10
-
48
-
-
18744381001
-
Neutrophil microtubules suppress polarity and enhance directional migration
-
Xu J., Wang F., Van Keymeulen A., Rentel M., Bourne H.R. Neutrophil microtubules suppress polarity and enhance directional migration. Proc. Natl. Acad. Sci. USA 2005, 102:6884-6889.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6884-6889
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Rentel, M.4
Bourne, H.R.5
-
49
-
-
0019827270
-
Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis
-
Zigmond S.H., Levitsky H.I., Kreel B.J. Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis. J.Cell Biol. 1981, 89:585-592.
-
(1981)
J.Cell Biol.
, vol.89
, pp. 585-592
-
-
Zigmond, S.H.1
Levitsky, H.I.2
Kreel, B.J.3
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