Investigation of epistasis between DAOA and 5HTR1A variants on clinical outcomes in patients with schizophrenia

Genetic Testing and Molecular Biomarkers

Volumn 17, Issue 6, 2013, Pages 504-507

  Chiesa, Alberto ^a,b   Lia, Loredana ^a   Han, Changsu ^c   Lee, Soo Jung ^d   Pae, Chi Un ^d,e   Serretti, Alessandro ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c Korea University   (South Korea)

^d The Catholic University of Korea   (South Korea)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYTRYPTAMINE RECEPTOR 1A; AMISULPRIDE; DEXTRO AMINO ACID OXIDASE; DEXTRO AMINO ACID OXIDASE ACTIVATOR; OLANZAPINE; QUETIAPINE; RISPERIDONE; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; EPISTASIS; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; EPISTASIS, GENETIC; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA;

EID: 84878539189     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2012.0484     Document Type: Article

References (21)

1. Abou Jamra R, Schmael C, Cichon S, et al. (2006) The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries? Schizophr Bull 32:599-608. (Pubitemid 44412845)
2. Andreasen NC, Wilcox MA, Ho BC, et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-1102.
3. Arranz MJ, Rivera M, Munro JC (2011) Pharmacogenetics of response to antipsychotics in patients with schizophrenia. CNS Drugs 25:933-969.
4. Carlborg O, Haley CS (2004) Epistasis: too often neglected in complex trait studies? Nat Rev Genet 5:618-625. (Pubitemid 39005756)
5. Chiesa A, Pae CU, Porcelli S, et al. (2011) DAOA variants and schizophrenia: influence on diagnosis and treatment outcome. Int J Psychiatry Clin Pract 15:303-310.
6. Cohen J (1988) Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Hillsdale, NJ.
7. Crisafulli C, Chiesa A, Han C, et al. (2012) Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics. Eur Arch Psychiatry Clin Neurosci 262:199-205.
8. Freedman R (2003) Schizophrenia. N Engl J Med 349:1738-1749. (Pubitemid 37315012)
9. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261-276. (Pubitemid 18039085)
10. Leucht S, Davis JM, Engel RR, et al. (2007) Defining 'response' in antipsychotic drug trials: recommendations for the use of scale-derived cutoffs. Neuropsychopharmacology 32:1903-1910. (Pubitemid 47258518)
11. McGuffin P, Owen MJ, Farmer AE (1995) Genetic basis of schizophrenia. Lancet 346:678-682.
12. Moon E, Rollins B, Mesen A, et al. (2011) Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophr Res 131: 52-57.
13. Phillips PC (2008) Epistasis-the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet 9:855-867.
14. Risch N, Herrell R, Lehner T, et al. (2009) Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301:2462-2471.
15. Segurado R, Bellgrove MA, Manconi F, et al. (2011) Epistasis between neurochemical gene polymorphisms and risk for ADHD. Eur J Hum Genet 19:577-582.
16. Serretti A, Chiesa A (2012) The challenge of uncovering the genetics of anxiety: An editorial comment to Arias B, Aguilera M, Moya J et al. 'The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits' (2). Acta Psychiatr Scand 125:185-186.
17. Sheehan DV, Lecrubier Y, Sheehan KH, et al. (1998) The miniinternational neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 Suppl 20:22-33;quiz 34-57. (Pubitemid 29001829)
18. Shi J, Badner JA, Gershon ES, et al. (2008) Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res 98:89-97. (Pubitemid 350235905)
19. StatSoft I (1995) STATISTICA per Windows. StatSoft Italia srl, Padova.
20. Zhang JP, Malhotra AK (2011) Pharmacogenetics and antipsy-chotics: therapeutic efficacy and side effects prediction. Expert Opin Drug Metab Toxicol 7:9-37.
21. Zimmerman M, Mattia JI, Posternak MA (2002) Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice? Am J Psychiatry 159:469-473. (Pubitemid 34184745)