Epistasis between neurochemical gene polymorphisms and risk for ADHD

European Journal of Human Genetics

Volumn 19, Issue 5, 2011, Pages 577-582

  Segurado, Ricardo ^a   Bellgrove, Mark A ^b   Manconi, Francesca ^c   Gill, Michael ^a   Hawi, Ziarah ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

ADHD; Candidate gene; Epistasis

Indexed keywords

ADRA1B GENE; ARTICLE; ATTENTION DEFICIT DISORDER; BIOSYNTHESIS; CATABOLISM; CHILD; DBH GENE; DNA POLYMORPHISM; GENE; GENETIC EPISTASIS; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; NEUROCHEMISTRY; PRIORITY JOURNAL; RISK FACTOR; SIGNAL TRANSDUCTION;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; DOPAMINE BETA-HYDROXYLASE; EPISTASIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 79955783750     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.250     Document Type: Article

References (30)

1. Gizer IR, Ficks C, Waldman ID: Candidate gene studies of ADHD: A meta-analytic review. Hum Genet 2009; 126: 51-90.
2. Li D, Sham PC, Owen MJ, He L: Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 2006; 15: 2276-2284. (Pubitemid 43994869)
3. Yang B, Chan RC, Jing J, Li T, Sham P, Chen RY: A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 541-550. (Pubitemid 46983166)
4. Neale BM, Medland SE, Ripke S et al: Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010; 49: 884-897.
5. Elena SF, Lenski RE: Test of synergistic interactions among deleterious mutations in bacteria. Nature 1997; 390: 395-398. (Pubitemid 28027318)
6. Clark AG, Wang L: Epistasis in measured genotypes: Drosophila P-element insertions. Genetics 1997; 147: 157-163. (Pubitemid 27385544)
7. Komili S, Roth FP: Genetic interaction screens advance in reverse. Genes Dev 2007; 21: 137-142. (Pubitemid 46155807)
8. Rio Frio T, Civic N, Ransijn A, Backmann JS, Rivolta C: Two trans-acting eQTLs modulate the penetrance of PRPF31 mutations. Hum Mol Genet 2008; 17: 3154-3165.
9. Cordell HJ: Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 2009; 10: 392-404.
10. Chatterjee N, Kalaylioglu Z, Moslehi R, Peters U, Wacholder S: Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. Am J Hum Genet 2006; 79: 1002-1016. (Pubitemid 44868070)
11. Autism Genome Project Consortium, Szatmari P, Paterson AD: Mapping autism risk loci using genetic linkage and chromosome rearrangements. Nat Genet 2007; 39: 319-328. (Pubitemid 46328498)
12. Neale BM, Laksy-Su J, Anney R et al: Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neurospychiatr Genet 2008; 147B: 1337-1344.
13. Pierce BL, Ahsan H: Case-only genome-wide interaction study of disease risk, prognosis and treatment. Genet Epidemiol 2009; 34: 7-15.
14. Cordell HJ, Barratt BJ, Clayton DG: Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol 2004; 26: 167-185. (Pubitemid 38420332)
15. Kirley A, Lowe N, Hawi Z et al: Association of the 480bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. Am J Med Genet B Neuropsychiatr Genet 2003; 121B: 50-54. (Pubitemid 37064030)
16. Hawi Z, Lowe N, Kirley A et al: Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. Mol Psychiatry 2003; 8: 299-308. (Pubitemid 36712923)
17. Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M, Hawi Z: Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: Evidence of linkage and association with the SNP -616. Am J Med Genet B Neuropsychiatr Genet 2004; 131B: 33-37. (Pubitemid 39458434)
18. Hawi Z, Segurado R, Conroy J et al: Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Am J Hum Genet 2005; 77: 958-965. (Pubitemid 41698517)
19. Kent L, Doerry U, Hardy E et al: Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): Analysis and pooled analysis. Mol Psychiatry 2002; 7: 908-912.
20. Gatto NM, Campbell UB, Rundle AG, Ahsan H: Further development of the case-only design for assessing gene-environment interaction: Evaluation of and adjustment for bias. Int J Epidemiol 2004; 33: 1014-1024. (Pubitemid 39429994)
21. O'Connell JR, Weeks DE: PedCheck: A program for the identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 2998; 63: 259-266.
22. Yang Q, Khoury MJ, Sun F, Flanders WD: Case-only design to measure gene-gene interaction. Epidemiology 1999; 10: 167-170. (Pubitemid 29093954)
23. Hurst LD, Pál C, Lercher MJ: The evolutionary dynamics of eukaryotic gene order. Nat Rev Genet 2004; 5: 299-310. (Pubitemid 38435625)
24. Roman T, Schimtz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH: Attention-deficit hyperactivity disorder: A study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet Neuropsychiatr Genet 2001; 195: 471-478. (Pubitemid 32601600)
25. Carrasco X, Rothhammer P, Moraga M et al: Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 51-54. (Pubitemid 43062542)
26. Henríquez H, Henríquez M, Carasco X et al: Combination of DRD4 and DAT1 genotypes is an important risk factor for attention deficit disorder with hyperactivity families living in Santiago, Chile. Rev Méd Chile 2008; 136: 719-724.
27. Retz W, Rösler M, Kissling C et al: Norepinephrine transporter and catecholamine-Omethyltransferase gene variants and attention-deficit/ hyperactivity disorder symptoms in adults. J Neural Transm 2008; 115: 323-329.
28. Stoltenberg SF: Epistasis among presynaptic serotonergic components. Behav Genet 2005; 35: 199-209.
29. Zabetian CP, Anderson GM, Buxbaum SG et al: A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet 2001; 68: 515-522. (Pubitemid 32147822)
30. Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP: 5-HT2A and alpha1badrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants. Eur J Neurosci 2004; 20: 3073-3084. (Pubitemid 40007302)