Microfluidic architectures for efficient generation of chemistry gradations in droplets

Microfluidics and Nanofluidics

Volumn 14, Issue 1-2, 2013, Pages 235-245

  Wegrzyn, Judyta ^a   Samborski, Adam ^a   Reissig, Louisa ^b   Korczyk, Piotr M ^a,c   Blonski, Slawomir ^c   Garstecki, Piotr ^a  

^a POLISH ACADEMY OF SCIENCES   (Poland)

^b NAGOYA UNIVERSITY   (Japan)

^c INSTITUTE OF FUNDAMENTAL TECHNOLOGICAL RESEARCH   (Poland)

Author keywords

Droplet; Generation of gradients; Microfluidics; Viscosity

Indexed keywords

DROPS; MIXTURES; VISCOSITY;

DROPLET FORMATION; GENERATION OF GRADIENTS; HIGH THROUGHPUT; INPUT STREAMS; MICRO DROPLETS; MICRO FLUIDIC SYSTEM; ORDERS OF MAGNITUDE;

MICROFLUIDICS;

EID: 84878526954     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-012-1042-3     Document Type: Article

References (48)

1. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using "flow focusing" in microchannels. Appl Phys Lett 82:364-366. doi: 10.1063/1.1537519
2. Berthier J, Le Vot S, Tiquet P, David N, Lauro D, Benhamou PY, Rivera F (2010) Highly viscous fluids in pressure actuated flow focusing devices. Sens Actuators A Phys 158:140-148. doi: 10.1016/j.sna.2009.12.016
3. Campbell K, Groisman A (2007) Generation of complex concentration profiles in microchannels in a logarithmically small number of steps. Lab Chip 7:264-272. doi: 10.1039/b610011b
4. Cao JL, Kursten D, Schneider S, Knauer A, Gunther PM, Kohler JM (2012) Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles. Lab Chip 12:474-484. doi: 10.1039/c1lc20584f
5. Christopher GF, Anna SL (2007) Microfluidic methods for generating continuous droplet streams. J Phys D Appl Phys 40:R319-R336. doi: 10.1088/0022-3727/40/19/r01
6. Christopher GF, Noharuddin NN, Taylor JA, Anna SL (2008) Experimental observations of the squeezing-to-dripping transition in T-shaped microfluidic junctions. Phys Rev E 78. doi: 10.1103/PhysRevE.78.036317
7. Chu LY, Utada AS, Shah RK, Kim JW, Weitz DA (2007) Controllable monodisperse multiple emulsions. Angew Chem Int Ed 46:8970-8974. doi: 10.1002/anie.200701358
8. Churski K, Korczyk P, Garstecki P (2010) High-throughput automated droplet microfluidic system for screening of reaction conditions. Lab Chip 10:816-818. doi: 10.1039/b925500a
9. Damean N, Olguin LF, Hollfelder F, Abell C, Huck WTS (2009) Simultaneous measurement of reactions in microdroplets filled by concentration gradients. Lab Chip 9:1707-1713. doi: 10.1039/b821021g
10. Dertinger SKW, Chiu DT, Jeon NL, Whitesides GM (2001) Generation of gradients having complex shapes using microfluidic networks. Anal Chem 73:1240-1246. doi: 10.1021/ac001132d
11. Dertinger SKW, Jiang XY, Li ZY, Murthy VN, Whitesides GM (2002) Gradients of substrate-bound laminin orient axonal specification of neurons. Proc Nat Acad Sci USA 99:12542-12547. doi: 10.1073/pnas.192457199
12. Derzsi L, Jankowski P, Lisowski W, Garstecki P (2011) Hydrophilic polycarbonate for generation of oil in water emulsions in microfluidic devices. Lab Chip 11:1151-1156. doi: 10.1039/c0lc00438c
13. Garstecki P, Stone HA, Whitesides GM (2005) Mechanism for flow-rate controlled breakup in confined geometries: a route to monodisperse emulsions. Phys Rev Lett 94. doi: 10.1103/PhysRevLett.94.164501
14. Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM (2006) Formation of droplets and bubbles in a microfluidic T-junction - scaling and mechanism of break-up. Lab Chip 6:437-446. doi: 10.1039/b510841a
15. Guillot P, Colin A (2005) Stability of parallel flows in a microchannel after a T junction. Phys Rev E 72. doi: 10.1103/PhysRevE.72.066301
16. Guillot P, Ajdari A, Goyon J, Joanicot M, Colin A (2009) Droplets and jets in microfluidic devices. C R Chim 12:247-257. doi: 10.1016/j.crci.2008.07. 005
17. Guzowski J, Korczyk PM, Jakiela S, Garstecki P (2011) Automated high-throughput generation of droplets. Lab Chip 11:3593-3595. doi: 10.1039/c1lc20595a
18. Hattori K, Sugiura S, Kanamori T (2009) Generation of arbitrary monotonic concentration profiles by a serial dilution microfluidic network composed of microchannels with a high fluidic-resistance ratio. Lab Chip 9:1763-1772. doi: 10.1039/b816995k
19. Husny J, Cooper-White JJ (2006) The effect of elasticity on drop creation in T-shaped microchannels. J Non Newton Fluid Mech 137:121-136. doi: 10.1016/j.jnnfm.2006.03.007
20. Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MC (2006) Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip 6:191-198. doi: 10.1039/b511877h
21. Jankowski P, Ogonczyk D, Kosinski A, Lisowski W, Garstecki P (2011) Hydrophobic modification of polycarbonate for reproducible and stable formation of biocompatible microparticles. Lab Chip 11:748-752. doi: 10.1039/c0lc00360c
22. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Microfabrication inside capillaries using multiphase laminar flow patterning. Science 285:83-85. doi: 10.1126/science.285.5424.83
23. Kim C, Lee K, Kim JH, Shin KS, Lee K-J, Kim TS, Kang JY (2008) A serial dilution microfluidic device using a ladder network generating logarithmic or linear concentrations. Lab Chip 8:473-479. doi: 10.1039/b714536e
24. Korczyk PM, Cybulski O, Makulska S, Garstecki P (2011) Effects of unsteadiness of the rates of flow on the dynamics of formation of droplets in microfluidic systems. Lab Chip 11:173-175. doi: 10.1039/c0lc00088d
25. Lee JN, Park C, Whitesides GM (2003) Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal Chem 75:6544-6554. doi: 10.1021/ac0346712
26. Lee K, Kim C, Kim Y, Jung K, Ahn B, Kang JY, Oh KW (2010) 2-layer based microfluidic concentration generator by hybrid serial and volumetric dilutions. Biomed Microdevices 12:297-309. doi: 10.1007/s10544-009-9385-6
27. Lee W, Walker LM, Anna SL (2011) Competition between viscoelasticity and surfactant dynamics in flow focusing microfluidics. Macromol Mater Eng 296:203-213. doi: 10.1002/mame.201000302
28. Li W, Nie Z, Zhang H, Paquet C, Seo M, Garstecki P, Kumacheva E (2007) Screening of the effect of surface energy of microchannels on microfluidic emulsification. Langmuir 23:8010-8014. doi: 10.1021/la7005875
29. Lin F, Saadi W, Rhee SW, Wang SJ, Mittal S, Jeon NL (2004) Generation of dynamic temporal and spatial concentration gradients using microfluidic devices. Lab Chip 4:164-167. doi: 10.1039/b313600k
30. Lorenz RM, Fiorini GS, Jeffries GDM, Lim DSW, He M, Chiu DT (2008) Simultaneous generation of multiple aqueous droplets in a microfluidic device. Anal Chim Acta 630:124-130. doi: 10.1016/j.aca.2008.10.009
31. Miller OJ, El Harrakb A, Mangeatb T, Bareta J-Ch, Frenza L, El Debsa B, Mayota E, Samuelsc ML, Eamonn K, Rooneyd E, Dieue P, Galvand M, Linkc DR, Griffithsa AD (2012) High-resolution dose-response screening using droplet-based microfluidics. PNAS 109:378-383. doi: 10.1073/pnas.1113324109
32. Neils C, Tyree Z, Finlayson B, Folch A (2004) Combinatorial mixing of microfluidic streams. Lab Chip 4:342-350. doi: 10.1039/b314962e
33. Nie Z, Seo M, Xu S, Lewis PC, Mok M, Kumacheva E, Whitesides GM, Garstecki P, Stone HA (2008) Emulsification in a microfluidic flow-focusing device: effect of the viscosities of the liquids. Microfluid Nanofluid 5:585-594. doi: 10.1007/s10404-008-0271-y
34. Nisisako T, Torii T (2008) Microfluidic large-scale integration on a chip for mass production of monodisperse droplets and particles. Lab Chip 8:287-293. doi: 10.1039/b713141k
35. Niu X, Gielen F, Edel JB, deMello AJ (2011) A microdroplet dilutor for high-throughput screening. Nature Chem 3:437-442. doi: 10.1038/NCHEM.1046
36. Ogonczyk D, Wegrzyn J, Jankowski P, Dabrowski B, Garstecki P (2010) Bonding of microfluidic devices fabricated in polycarbonate. Lab Chip 10:1324-1327. doi: 10.1039/b924439e
37. Seo M, Nie ZH, Xu SQ, Mok M, Lewis PC, Graham R, Kumacheva E (2005) Continuous microfluidic reactors for polymer particles. Langmuir 21:11614-11622. doi: 10.1021/la050519e
38. Song H, Chen DL, Ismagilov RF (2006) Reactions in droplets in microfluidic channels. Angew Chem Int Ed 45:7336-7356. doi: 10.1002/anie. 200601554
39. Thorsen T, Roberts RW, Arnold FH, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device. Phys Rev Lett 86:4163-4166. doi: 10.1103/PhysRevLett.86.4163
40. Tice JD, Lyon AD, Ismagilov RF (2004) Effects of viscosity on droplet formation and mixing in microfluidic channels. Anal Chim Acta 507:73-77. doi: 10.1016/j.aca.2003.11.024
41. Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA (2005) Monodisperse double emulsions generated from a microcapillary device. Science 308:537-541. doi: 10.1126/science.1109164
42. van Steijn V, Kleijn CR, Kreutzer MT (2010) Predictive model for the size of bubbles and droplets created in microfluidic T-junctions. Lab Chip 10:2513-2518. doi: 10.1039/c002625e
43. Xu SQ, Nie ZH, Seo M, Lewis P, Kumacheva E, Stone HA, Garstecki P, Weibel DB, Gitlin I, Whitesides GM (2005) Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew Chem Int Ed 44:724-728. doi: 10.1002/anie.200462226
44. Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG (2009) Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small 5:1575-1581. doi: 10.1002/smll.200801855
45. Yamada M, Hirano T, Yasuda M, Seki M (2006) A microfluidic flow distributor generating stepwise concentrations for high-throughput biochemical processing. Lab Chip 6:179-184. doi: 10.1039/b514045d
46. Yeom S, Lee SY (2011) Size prediction of drops formed by dripping at a micro T-junction in liquid-liquid mixing. Exp Thermal Fluid Sci 35:387-394. doi: 10.1016/j.expthermflusci.2010.10.009
47. Yusuf HA, Baldock SJ, Fielden PR, Goddard NJ, Mohr S, Brown BJT (2010) Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol. Microfluid Nanofluid 8:587-598. doi: 10.1007/s10404-009-0489-3
48. Zheng B, Gerdts CJ, Ismagilov RF (2005) Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr Opin Struct Biol 15:548-555. doi: 10.1016/j.sbi.2005.08.009