Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol

Microfluidics and Nanofluidics

Volumn 8, Issue 5, 2010, Pages 587-598

  Yusuf, Hayat Abdulla ^a   Baldock, Sara J ^a   Fielden, Peter R ^a   Goddard, Nick J ^a   Mohr, Stephan ^a   Brown, Bernard J Treves ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Glycerol; Linear concentration gradient; Microfabrication; Microfluidic device; Optical detection; Viscous inlets

Indexed keywords

ANALYTICAL MODELLING; CONCENTRATION DISTRIBUTIONS; CONCENTRATION GRADIENTS; CONTROLLED INLET; EXPERIMENTAL STUDIES; GRADIENT NETWORKS; INLET CONCENTRATION; LINEAR CONCENTRATION; LINEAR CONCENTRATION GRADIENT; LINEARISATION; MICRO-FLUIDIC DEVICES; MICROFLUIDIC NETWORKS; OPTICAL DETECTION; OPTICAL MEASUREMENT; WITH INLETS;

CONCENTRATION (PROCESS); EXPERIMENTS; FLUIDIC DEVICES; GLYCEROL; LINEARIZATION; MATHEMATICAL MODELS; MICROANALYSIS; MICROFABRICATION; MICROFLUIDICS; MICROMACHINING; OPTICAL DATA PROCESSING; VISCOSITY;

INLET FLOW;

EID: 77954762824     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-009-0489-3     Document Type: Article

References (30)

1. Abdulla Yusuf H, Baldock SJ, Barber RW, Fielden PR, Goddard NJ, Treves Brown BJ (2008) Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation. Microelectron Eng 85:1265-1268
2. Abdulla Yusuf H, Baldock SJ, Barber RW, Fielden PR, Goddard NJ, Mohr S, Treves Brown BJ (2009a) Optimisation and analysis of microreactor designs for microfluidic gradient generation using a purpose built optical detection system for entire chip imaging. Lab Chip 9:1882-1889
3. Abdulla Yusuf H, Baldock SJ, Mohr S, Fielden PR, Goddard NJ, Treves Brown BJ (2009b) Optical imaging and analytical modelling of the dynamic concentration gradient of viscous inlet solutions in a microfabricated network design. Microelectron Eng 86:1361-1364
4. Burdick JA, Khademhosseini A, Langer R (2004) Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 20:5153-5156
5. Campbell K, Groisman A (2007) Generation of complex concentration profiles in microchannels in a logarithmically small number of steps. Lab Chip 7:264-272
6. Cao X, Shoichet MS (2001) Defining the concentration gradient of nerve growth factor for guided neurite outgrowth. Neuroscience 103:831-840
7. Cheng NS (2008) Formula for the viscosity of a glycerol-water mixture. Ind Eng Chem Res 47:3285-3288
8. Chung BG, Flanagan LA, Rhee SW, Schwartz PH, Lee AP, Monuki ES, Jeon NL (2005) Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 5:401-406
9. Dertinger S K W, Chiu DT, Jeon NL, Whitesides GM (2001) Generation of gradients having complex shapes using microfluidic networks. Anal Chem 73:1240-1246
10. Gorman B, Wikswo J (2008) Characterization of transport in microfluidic gradient generators. Microfluid Nanofluid 4:273-285
11. Groß G, Thyagarajan V, Kielpinski M, Henkel T, Köhler J (2008) Viscosity-dependent enhancement of fluid resistance in water/glycerol micro fluid segments. Microfluid Nanofluid 5:281-287
12. Hattori K, Sugiura S, Kanamori T (2009) Generation of arbitrary monotonic concentration profiles by a serial dilution microfluidic network composed of microchannels with a high fluidic-resistance ratio 9:1763-1772
13. Irimia D, Geba DA, Toner M (2006) Universal microfluidic gradient generator. Anal Chem 78:3472-3477
14. Jeon NL, Dertinger S K W, Chiu DT, Choi IS, Stroock AD, Whitesides GM (2000) Generation of solution and surface gradients using microfluidic systems. Langmuir 16:8311-8316
15. Jeon NL, Baskaran H, Dertinger S K W, Whitesides GM, Water L V D, Toner M (2002) Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol 20:826-830
16. Lee K, Kim C, Ahn B, Panchapakesan R, Full AR, Nordee L, Kang JY, Oh KW (2009) Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators. Lab Chip 9:709-717
17. Lin F, Nguyen CM-C, Wang S-J, Saadi W, Gross SP, Jeon NL (2004) Effective neutrophil chemotaxis is strongly influenced by mean iL-8 concentration. Biochem Biophys Res Commun 319:576-581
18. Liu YZ, Kim BJ, Sung HJ (2004) Two-fluid mixing in a microchannel. Int J Heat Fluid Flow 25:986-995
19. Miller JC, Miller JN (1984) Statistics for analytical chemistry. Ellis Horwood, Chichester
20. Mohr S, Zhang YH, Macaskill A, Day P J R, Barber RW, Goddard NJ, Emerson DR, Fielden PR (2007) Numerical and experimental study of a droplet-based PCR chip. Microfluid Nanofluid 3:611-621
21. Murdoch J, Barnes JA (1998) Statistical tables: for students of science, engineering, psychology, business
22. Nishijima Y, Oster G (1960) Diffusion in glycerol-water mixture. Bull Chem Soc Jpn 33:1649-1651
23. Rozen A (2007) Reactive micromixing of liquids of equal and different viscosities in a shear flow. Chem Process Eng (Inzynieria Chemiczna i Procesowa) 28:1045-1056
24. Rozen A, Baldyga J (2006) Laminar micromixing of liquids of equal and unequal viscosities. The role of characteristic time scales of the process. Chem Process Eng (Inzynieria Chemiczna i Procesowa) 27:335-347
25. Saadi W, Wang S-J, Lin F, Jeon NL (2006) A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis. Biomed Microdevices 8:109-118
26. Sun K, Wang Z, Jiang X (2008) Modular microfluidics for gradient generation. Lab Chip 8:1536-1543
27. Thompson DM, King KR, Wieder KJ, Toner M, Yarmush ML, Jayaraman A (2004) Dynamic gene expression profiling using a microfabricated living cell array. Anal Chem 76:4098-4103
28. Walker GM, Monteiro-Riviere N, Rouse J, O'Neill AT (2007) A linear dilution microfluidic device for cytotoxicity assays. Lab Chip 7:226-232
29. Yang M, Yang J, Li C-W, Zhao J (2002) Generation of concentration gradient by controlled flow distribution and diffusive mixing in a microfluidic chip. Lab Chip 2:158-163
30. Ye N, Qin J, Shi W, Liu X, Lin B (2007) Cell-based high content screening using an integrated microfluidic device. Lab Chip 7:1696-1704