Large-molecule quantification: Sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF

Bioanalysis

Volumn 5, Issue 10, 2013, Pages 1181-1193

  Morin, Louis Philippe ^a   Mess, Jean Nicholas ^a   Garofolo, Fabio ^a  

^a Algorithme Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; DESMOPRESSIN; ENFUVIRTIDE; EXENDIN 4; GLUCAGON; SOMATOSTATIN;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; LIGAND BINDING; LIMIT OF QUANTITATION; MOLECULAR MODEL; PEPTIDE ANALYSIS; PHASE TRANSITION; PROCESS OPTIMIZATION; QUADRUPOLE MASS SPECTROMETRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SELECTIVE REACTION MONITORING; SENSITIVITY ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

CALCITONIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEAMINO ARGININE VASOPRESSIN; GLUCAGON; HIV ENVELOPE PROTEIN GP41; HUMANS; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; PEPTIDES; SENSITIVITY AND SPECIFICITY; SOMATOSTATIN; VENOMS;

EID: 84878497938     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.87     Document Type: Article

References (23)

1. Fung E, Xia Y, Aubry A-F, Zeng J, Olah T, Jemal M. Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma. J. Chromatog. B 879, 2919-2927 (2011).
2. Ramanathan R, Korfmacher W. The emergence of high resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena. Bioanalysis 4(5), 467-469 (2012).
3. Ramanathan R, Jemal M, Ramagiri S, Xia Y, Humpreys G, Olah T, Korfmacher W. It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. J. Mass Spectrom. 46, 595-601 (2011).
4. th American Society for Mass Spectrometry Conference. Denver, CO, USA, 5-9 June, 2011.
5. Mess J-N, Morin L-P, Ramagiri S, Garofolo F et al. Advanced application of a high resolution quadrupole time-of-fight mass spectrometer to resolve chemical noise in regulated bioanalysis. Presented at: 59th American Society for Mass Spectrometry Conference. Denver, CO, USA, 5-9 June, 2011.
6. Wei C, Grace E, Zvyaga T, Drexler D. Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavrin and its phosphate metabolites. Bioanalysis 4 (15), 1895-1905 (2012).
7. Chernushevish I, Loboda A, Thomson B. An introduction to quadrupole-time-of-fight spectrometer. J. Mass Spectrom. 36, 849-865 (2001).
8. Balogh M. Debating resolution and mass accuracy. LC-GC Europe 17 (3), 152-159 (2004).
9. Shen H-W, Yu A-M. New analytical technologies for bioanalytical discovery. Bionalaysis 2 (2), 181-184 (2010).
10. Van den Broek I, Sparidans R, Schellens J, Beijein J. Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry. J. Chromatogr. B 872, 1-22 (2008).
11. Thomas A, Solymos E, Schanzer W, Baume N, Saugy M, Dellana F, Thevis M. Determination of vassopressin and desmopressin in urine by means of liquid chromatography coupled to quadrupole time-of-fight mass spectrometry for doping control purposes. Analytica Chimica Acta 707, 107-113 (2011).
12. th American Society for Mass Spectrometry Conference. Denver, CO, USA, 5-9 June, 2011.
13. Hoofnagle A, Wener M. The fundamental faws of immunoassays and potential solutions using tandem mass spectrometry. J. Immunological Methods 347, 3-11 (2009).
14. Xia Y, Lau J, Walker B, Fung N, Olah T, Jemal M. High resolution MS for quantitation of drugs in plasma: evaluation of resolution and mass extraction windows to achieve required selectivity. Presented at: 58th American Society for Mass Spectrometry Conference. Salt Lake City, UT, USA, 23-27 May, 2010.
15. Morin L-P, Mess J-N, Ramagiri S, Garofolo F et al. Elimination of selectivity and quantifcation issues during ursodiol regulated bioanalysis by using a high resolution quadrupole time-of-fight mass spectrometer. Presented at: 59th American Society for Mass Spectrometry Conference. Denver, CO, USA, 5-9 June, 2011.
16. Ramagiri S, Garofolo F. Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges. Bioanalysis 4(5), 529-540 (2012).
17. Dillen L, Cools W, Lorreyne W et al. Comparison of triple quadrupole and high-resolution TOF-MS for quantifcation of peptide. Bioanalysis 4(5), 565-579 (2012).
18. Henion J, Zhang H. Comparison between liquid chromatography-time of fight mass spectrometer and selected reaction monitoring liquid chromatography-mass spectrometry for determination of idoxifene in human plasma. J. Chromatogr. B 757, 151-159 (2001).
19. Chen Y, Qiao S, Wang C. Fragmentation of peptides with intra-chain disulfte bonds in triple quadrupole mass spectrometry and its quantitative application to biological samples. Int. J. Mass Spectrum. 288, 68-74 (2009).
20. Meymaris A, Lelacheur R, Bennett P, Cook K, Zhang X. Evalaution of resolution/scan speed for quantitation of small molecules by LC-HRMS on the Q-Exactive plateform. Presented at: 60th American Society for Mass Spectrometry Conference. Vancouver, BC, Canada, 19-24 May, 2012.
21. DeSilva B, Garofolo F, Rocci M, Bateman K et al. 2012 White Paper on recent issues in bioanalysis and alignment of multiple guidelines. Bioanalysis 4(18), 2213-2226 (2012).
22. Gil J, Cabrales A, Reyes O, Morena V et al. Development and validation of a bioanalytical LC-MS method for the quantitation of GHRP-6 in human plasma. J. Pharm. Biomed. Anal. 60, 19-25 (2012).
23. Timmerman P. First EBF refection on method validation criteria for peptide/protein analysis with LC-MS based technique. Presented at: 2nd EBF Focus meeting-Large meets small. Brussels, Belgium, 21-22 June 2011.