Longer HSD11B2 CA-repeat in impaired glucose tolerance and type 2 diabetes

Endocrine Journal

Volumn 60, Issue 5, 2013, Pages 671-678

  Mune, Tomoatsu ^a   Suwa, Tetsuya ^b   Morita, Hiroyuki ^b   Isomura, Yukinori ^b   Takada, Nobuki ^c   Yamamoto, Yoritsuna ^c   Hayashi, Makoto ^d   Yamakita, Noriyoshi ^d   Sasaki, Akihiko ^e   Takeda, Noriyuki ^e   Takeda, Jun ^b   White, Perrin C ^f   Kaku, Kohei ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c Japan Self Defense Force Gifu Hospital   (Japan)

^d Matsunami General Hospital   (Japan)

^e Murakami Memorial Hospital   (Japan)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

11 hydroxysteroid dehydrogenase type 2; Cortisol; Cortisone; Insulin; Pancreas

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HETEROZYGOSITY; HSD11B2 GENE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INTRON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADULT; ALLELES; CORTISONE; DIABETES MELLITUS, TYPE 2; DINUCLEOTIDE REPEATS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE INTOLERANCE; HUMANS; HYDROCORTISONE; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 84878495474     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ12-0108     Document Type: Article

References (22)

1. White PC, Mune T, Agarwal AK (1997) 11beta-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18: 135-156.
2. Mune T, Rogerson FM, Nikkilä H, Agarwal AK, White PC (1995) Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nat Genet 10: 394-399.
3. Stewart PM, Wallace AM, Valentino R, Burt D, Schackleton CHL, et al. (1987) Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 2: 821-824.
4. Funder JW, Pearce PT, Smith R, Smith AI (1988) Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 242: 583-585.
5. Kataoka S, Kudo A, Hirano H, Kawasaki H, Kawano T, et al. (2002) 11β-Hydroxysteroid dehydrogenase type 2 is expressed in the human kidney glomerulus. J Clin Endocrinol Metab 87: 877-882.
6. Condon J, Gosden C, Gardener D, Nickson P, Hewison M, et al. (1998) Expression of type 2 11β-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. J Clin Endocrinol Metab 83: 4490-4497.
7. Morita H, Isomura Y, Mune T, Daido H, Takami R, et al. (2004) Plsama cortisol and cortisone concentrations in normal subjects and patients with adrenocortical disorders. Metabolism 53: 89-94.
8. Mune T, Morita H, Suzuki T, Takahashi Y, Isomura Y, et al. (2003) Role of local 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) expression in determining the phenotype of adrenal adenomas. J Clin Endocrinol Metab 88: 864-870.
9. Lenzen S, Bailey CJ (1984) Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr Rev 5: 411-434.
10. Lambillotte C, Gilon P, Henquin JC (1997) Direct glucocorticoid inhibition of insulin secretion: an in vitro study of dexamethasone effects in mouse islets. J Clin Invest 99: 414-423.
11. Lovati E, Ferrari P, Dick B, Jostarndt K, Frey BM, et al. (1999) Molecular basis of human salt sensitivity: The role of the 11β-hydroxysteroid dehydrogenase type 2. J Clin Endocrinol Metab 84: 3745-3749.
12. Agarwal AK, Giacchetti G, Lavery G, Nikkila H, Palermo M, et al. (2000) CA-repeat polymorphism in intron 1 of HSD11B2: Effects on gene expression and salt sensitivity. Hypertension 36: 187-194.
13. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183-1197.
14. Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, et al. (2012) International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Invest 3: 39-40.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28: 412-419.
16. Watson B, Bergman SM, Myracle A, Callen DF, Acton RT, et al. (1996) Genetic association of HSD11B2 flanking microsatellites with essential hypertension in blacks. Hypertension 28: 478-482.
17. Smolenicka Z, Bach E, Schaer A, Liechti-Gallati S, Frey BM, et al. (1998) A new polymorphic restriction site in the human 11β-hydroxysteroid dehydrogenase gene. J Clin Endocrinol Metab 83: 1814-1817.
18. White PC, Agarwal AK, Li A, Nikkila H, Pratt JH, et al. (2001) Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11β-hydroxysteroid dehydrogenase to hypertension in Black people. Clin Endocrinol 55: 249-252.
19. Walker BR (2000) Cortisol in insulin resistance syndromes. In: Walker M, Butler P, Rizza RA (ed) The Diabetes Annual (13). Elsevier Science, Amsterdam: 137-157.
20. Delaunay F, Khan A, Cintra A, Davani B, Ling ZC, et al. (1997) Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. J Clin Invest 100: 2094-2098.
21. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (1994) Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105: R11-17.
22. Hirasawa G, Sasano H, Takahashi K, Fukushima K, Suzuki T, et al. (1997) Colocalization of 11β-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia. J Clin Endocrinol Metab 82: 3859-3863.