-
1
-
-
33846055491
-
Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine
-
Sato Y, He JX, Nagai H, Tani T, Akao T, (2007) Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharma Bull 30: 145-149.
-
(2007)
Biol Pharma Bull
, vol.30
, pp. 145-149
-
-
Sato, Y.1
He, J.X.2
Nagai, H.3
Tani, T.4
Akao, T.5
-
2
-
-
0035986278
-
Pharmacological aspects of erectile dysfunction
-
Thomas JA, (2002) Pharmacological aspects of erectile dysfunction. Jap J Pharma 89: 101-112.
-
(2002)
Jap J Pharma
, vol.89
, pp. 101-112
-
-
Thomas, J.A.1
-
4
-
-
33645989786
-
Prophylactic treatment of migraine in children. Part 2. Asystematic review of pharmacological trials
-
Damen L, Bruijn J, Verhagen AP, Berger MY, Passchier J, et al. (2006) Prophylactic treatment of migraine in children. Part 2. Asystematic review of pharmacological trials. Cephalagia 26: 497-505.
-
(2006)
Cephalagia
, vol.26
, pp. 497-505
-
-
Damen, L.1
Bruijn, J.2
Verhagen, A.P.3
Berger, M.Y.4
Passchier, J.5
-
5
-
-
33947302705
-
Phosphoesterase 10 A inhibiters: A novel approach to the symptoms of schizophrenia
-
Menniti FS, Chappie TA, Humphrey JM, Schmidt CJ, (2007) Phosphoesterase 10 A inhibiters: A novel approach to the symptoms of schizophrenia. Curr Opin Invest Drugs 8: 54-59.
-
(2007)
Curr Opin Invest Drugs
, vol.8
, pp. 54-59
-
-
Menniti, F.S.1
Chappie, T.A.2
Humphrey, J.M.3
Schmidt, C.J.4
-
7
-
-
20444396193
-
Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms
-
Liscombe DK, MacLeod BP, Loukanina N, Nandi OI, Facchini PJ, (2005) Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms. Phytochemisty 66: 2501-2520.
-
(2005)
Phytochemisty
, vol.66
, pp. 2501-2520
-
-
Liscombe, D.K.1
MacLeod, B.P.2
Loukanina, N.3
Nandi, O.I.4
Facchini, P.J.5
-
8
-
-
78649499936
-
Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family
-
Lee EJ, Facchini PJ, (2010) Norcoclaurine synthase is a member of the pathogenesis-related 10/Bet v1 protein family. Plant Cell 22: 3489-3503.
-
(2010)
Plant Cell
, vol.22
, pp. 3489-3503
-
-
Lee, E.J.1
Facchini, P.J.2
-
9
-
-
0032033414
-
Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (Cyp80b1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis
-
Pauli HH, Kutchan TM, (1998) Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (Cyp80b1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis. Plant J 13: 793-801.
-
(1998)
Plant J
, vol.13
, pp. 793-801
-
-
Pauli, H.H.1
Kutchan, T.M.2
-
10
-
-
0042823501
-
Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy
-
Facchini PJ, Park SU, (2003) Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry 64: 177-186.
-
(2003)
Phytochemistry
, vol.64
, pp. 177-186
-
-
Facchini, P.J.1
Park, S.U.2
-
11
-
-
26644468125
-
Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis
-
Ziegler J, Diaz-Chávez M, Kramell R, Ammer C, Kutchan TM, (2005) Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis. Planta 222: 458-471.
-
(2005)
Planta
, vol.222
, pp. 458-471
-
-
Ziegler, J.1
Diaz-Chávez, M.2
Kramell, R.3
Ammer, C.4
Kutchan, T.M.5
-
12
-
-
44049113918
-
Formation of salutaridine from (R)- reticuline by a membrane bound cytochrome P450 enzyme from Papaver somniferum
-
Gerardy R, Zenk MH, (1993) Formation of salutaridine from (R)- reticuline by a membrane bound cytochrome P450 enzyme from Papaver somniferum. Phytochemistry 32: 79-86.
-
(1993)
Phytochemistry
, vol.32
, pp. 79-86
-
-
Gerardy, R.1
Zenk, M.H.2
-
13
-
-
0033152629
-
Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum
-
Unterlinner B, Lenz R, Kutchan TM, (1999) Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum. Plant J 18: 465-475.
-
(1999)
Plant J
, vol.18
, pp. 465-475
-
-
Unterlinner, B.1
Lenz, R.2
Kutchan, T.M.3
-
14
-
-
2142751582
-
1, 2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway
-
Hirata K, Poeaknapo C, Schmidt J, Zenk MH, (2004) 1, 2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. Phytochemistry 65: 1039-1046.
-
(2004)
Phytochemistry
, vol.65
, pp. 1039-1046
-
-
Hirata, K.1
Poeaknapo, C.2
Schmidt, J.3
Zenk, M.H.4
-
15
-
-
33749241876
-
Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis
-
Ziegler J, Voigtländer S, Schmidt J, Kramell R, Miersch O, et al. (2006) Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis. Plant J 48: 177-192.
-
(2006)
Plant J
, vol.48
, pp. 177-192
-
-
Ziegler, J.1
Voigtländer, S.2
Schmidt, J.3
Kramell, R.4
Miersch, O.5
-
16
-
-
69949174213
-
CYP719B1 is salutaridine synthase, the C-C phenolcoupling enzyme of morphine biosynthesis in opium poppy
-
Gesell A, Rolf M, Ziegler J, Díaz-Chávez ML, Huang FC, et al. (2009) CYP719B1 is salutaridine synthase, the C-C phenolcoupling enzyme of morphine biosynthesis in opium poppy. J Biol Chem 284: 24432-24442.
-
(2009)
J Biol Chem
, vol.284
, pp. 24432-24442
-
-
Gesell, A.1
Rolf, M.2
Ziegler, J.3
Díaz-Chávez, M.L.4
Huang, F.C.5
-
17
-
-
77949847651
-
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy
-
Hagel JM, Facchini PJ, (2010) Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat Chem Biol 6: 273-275.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 273-275
-
-
Hagel, J.M.1
Facchini, P.J.2
-
18
-
-
84862988247
-
Plant Gene Clusters and Opiates
-
Penna DD, O'Connor SE, (2012) Plant Gene Clusters and Opiates. Science 336: 1648.
-
(2012)
Science
, vol.336
, pp. 1648
-
-
Penna, D.D.1
O'Connor, S.E.2
-
19
-
-
0015151896
-
Opium alkaloids X. Biosynthesis of benzylisoquinolines
-
Brochmann-Hanssen E, Leung AY, Fu CC, Zanati G, (1971) Opium alkaloids X. Biosynthesis of benzylisoquinolines. J Pharmocol Sci 60: 1672-1676.
-
(1971)
J Pharmocol Sci
, vol.60
, pp. 1672-1676
-
-
Brochmann-Hanssen, E.1
Leung, A.Y.2
Fu, C.C.3
Zanati, G.4
-
20
-
-
0016605098
-
Opium alkaloids. Part XVI. The biosynthesis of benzylisoquinolines in Papaver somniferum. Preferred and secondary pathways; stereo chemical aspects
-
Brochmann-Hanssen E, Chen CH, Chen CR, Chiang HC, Leung AY, et al. (1975) Opium alkaloids. Part XVI. The biosynthesis of benzylisoquinolines in Papaver somniferum. Preferred and secondary pathways; stereo chemical aspects. J Chem Soc 16: 1531-1537.
-
(1975)
J Chem Soc
, vol.16
, pp. 1531-1537
-
-
Brochmann-Hanssen, E.1
Chen, C.H.2
Chen, C.R.3
Chiang, H.C.4
Leung, A.Y.5
-
21
-
-
70349499351
-
Functional characterization of a novel benzylisoquinoline-O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L)
-
Pienkny S, Brandt W, Schmidt J, Kramell R, Ziegler J, (2009) Functional characterization of a novel benzylisoquinoline-O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L). Plant J 60: 56-67.
-
(2009)
Plant J
, vol.60
, pp. 56-67
-
-
Pienkny, S.1
Brandt, W.2
Schmidt, J.3
Kramell, R.4
Ziegler, J.5
-
22
-
-
0347317979
-
(R, S)-Reticuline 7-O-methyltransferase and (R, S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum- cDNA cloningand characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy
-
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM, (2003) (R, S)-Reticuline 7-O-methyltransferase and (R, S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum- cDNA cloningand characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. Plant J 36: 808-819.
-
(2003)
Plant J
, vol.36
, pp. 808-819
-
-
Ounaroon, A.1
Decker, G.2
Schmidt, J.3
Lottspeich, F.4
Kutchan, T.M.5
-
23
-
-
77954242676
-
The biosynthesis of papaverine proceeds via (S)-reticuline
-
Han X, Lamshoft M, Grobe N, Ren X, Fist AJ, et al. (2010) The biosynthesis of papaverine proceeds via (S)-reticuline. Phytochemistry 71: 1305-1312.
-
(2010)
Phytochemistry
, vol.71
, pp. 1305-1312
-
-
Han, X.1
Lamshoft, M.2
Grobe, N.3
Ren, X.4
Fist, A.J.5
-
24
-
-
84861878374
-
Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy
-
Dang TT, Facchini PJ, (2012) Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy. Plant Physiol 159: 618-631.
-
(2012)
Plant Physiol
, vol.159
, pp. 618-631
-
-
Dang, T.T.1
Facchini, P.J.2
-
25
-
-
84867576863
-
Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy
-
Desgagné-Penix I, Facchini PJ, (2012) Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. Plant J 72: 331-344.
-
(2012)
Plant J
, vol.72
, pp. 331-344
-
-
Desgagné-Penix, I.1
Facchini, P.J.2
-
26
-
-
44949127129
-
Alkaloid biosynthesis: metabolism and trafficking
-
Ziegler J, Facchini PJ, (2008) Alkaloid biosynthesis: metabolism and trafficking. Annu Rev Plant Biol 59: 735-769.
-
(2008)
Annu Rev Plant Biol
, vol.59
, pp. 735-769
-
-
Ziegler, J.1
Facchini, P.J.2
-
27
-
-
78349297591
-
Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures
-
Desgagné-Penix I, Khan MF, Schriemer DC, Nowak J, Facchini PJ, (2010) Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures. BMC Plant Biol 10: 252-268.
-
(2010)
BMC Plant Biol
, vol.10
, pp. 252-268
-
-
Desgagné-Penix, I.1
Khan, M.F.2
Schriemer, D.C.3
Nowak, J.4
Facchini, P.J.5
-
28
-
-
84862983651
-
Mining the biodiversity of plants: a revolution in the making
-
Luca VD, Salim V, Atsumi SM, Yu F, (2012) Mining the biodiversity of plants: a revolution in the making. Science 336: 1658.
-
(2012)
Science
, vol.336
, pp. 1658
-
-
Luca, V.D.1
Salim, V.2
Atsumi, S.M.3
Yu, F.4
-
29
-
-
4644293708
-
Analgesia: morphine-pathway block in top1 poppies
-
Millgate AG, Pogson BJ, Wilson IW, Kutchan TM, Zenk MH, et al. (2004) Analgesia: morphine-pathway block in top1 poppies. Nature 431: 413-414.
-
(2004)
Nature
, vol.431
, pp. 413-414
-
-
Millgate, A.G.1
Pogson, B.J.2
Wilson, I.W.3
Kutchan, T.M.4
Zenk, M.H.5
-
30
-
-
0034069495
-
Gene ontology: tool for the unification of biology
-
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. Nat Genet 25: 25-29.
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
Botstein, D.4
Butler, H.5
-
31
-
-
34547588704
-
KAAS: an automatic genome annotation and pathway reconstruction server
-
Moriya Y, Itoh M, Okuda S, Yoshizawa AC, Kanehisa M, (2007) KAAS: an automatic genome annotation and pathway reconstruction server. Nucl Acids Res 35: W182-W185.
-
(2007)
Nucl Acids Res
, vol.35
-
-
Moriya, Y.1
Itoh, M.2
Okuda, S.3
Yoshizawa, A.C.4
Kanehisa, M.5
-
32
-
-
0034518635
-
The Comparison of Gene Expression from Multiple cDNA Libraries
-
Stekel D J, Git Y, Falciani F, (2000) The Comparison of Gene Expression from Multiple cDNA Libraries. Genome Res 10: 2055-2061.
-
(2000)
Genome Res
, vol.10
, pp. 2055-2061
-
-
Stekel, D.J.1
Git, Y.2
Falciani, F.3
-
33
-
-
0032441150
-
Cluster analysis and display of genome wide expression patterns
-
Eisen MB, Spellman PT, Brown PO, Botstein D, (1998) Cluster analysis and display of genome wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14863-14868
-
-
Eisen, M.B.1
Spellman, P.T.2
Brown, P.O.3
Botstein, D.4
-
34
-
-
77957199600
-
Modulated gene expression in newly synthesized auto-tetraploid of Papaver somniferum L
-
Mishra BK, Pathak S, Sharma A, Trivedi PK, Shukla S, (2010) Modulated gene expression in newly synthesized auto-tetraploid of Papaver somniferum L. S Afr J Bot 76: 447-452.
-
(2010)
S Afr J Bot
, vol.76
, pp. 447-452
-
-
Mishra, B.K.1
Pathak, S.2
Sharma, A.3
Trivedi, P.K.4
Shukla, S.5
-
35
-
-
84865434759
-
High frequency somatic embryogenesis, regeneration and correlation of alkaloid biosynthesis with gene expression in Papaver somniferum
-
Pathak S, Mishra BK, Misra P, Misra P, Joshi VK, et al. (2012) High frequency somatic embryogenesis, regeneration and correlation of alkaloid biosynthesis with gene expression in Papaver somniferum. Plant Growth Regul 68: 17-25.
-
(2012)
Plant Growth Regul
, vol.68
, pp. 17-25
-
-
Pathak, S.1
Mishra, B.K.2
Misra, P.3
Misra, P.4
Joshi, V.K.5
-
36
-
-
0025830703
-
Inheritance of papaverine in Papaver somniferum L. and a morphological marker for high papaverine plants
-
Khanna KR, Shukla S, (1991) Inheritance of papaverine in Papaver somniferum L. and a morphological marker for high papaverine plants. Herba Hungarica 30: 7-10.
-
(1991)
Herba Hungarica
, vol.30
, pp. 7-10
-
-
Khanna, K.R.1
Shukla, S.2
-
37
-
-
0032916550
-
Genetic systems involved in the inheritance of papaverine in opium poppy (Papaver somniferum L.)
-
Shukla S, Singh SP, (1999) Genetic systems involved in the inheritance of papaverine in opium poppy (Papaver somniferum L.). Ind J Agri Sci 69: 44-47.
-
(1999)
Ind J Agri Sci
, vol.69
, pp. 44-47
-
-
Shukla, S.1
Singh, S.P.2
-
38
-
-
4644289320
-
The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum
-
Weid M, Ziegler J, Kutchan TM, (2004) The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. Proc Natl Acad Sci USA 101: 13957-13962.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13957-13962
-
-
Weid, M.1
Ziegler, J.2
Kutchan, T.M.3
-
39
-
-
84860840868
-
Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy
-
Desgagné-Penix I, Farrow SC, Cram D, Nowak J, Facchini PJ, (2012) Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy. Plant Mol Biol 3: 295-313.
-
(2012)
Plant Mol Biol
, vol.3
, pp. 295-313
-
-
Desgagné-Penix, I.1
Farrow, S.C.2
Cram, D.3
Nowak, J.4
Facchini, P.J.5
-
40
-
-
0019163641
-
Biosynthesis of unnatural papaverine derivatives in Papaver somniferum
-
Brochmann-Hanssen E, Chen CY, Linn EE, (1980) Biosynthesis of unnatural papaverine derivatives in Papaver somniferum. J Nat Prod 43: 736-738.
-
(1980)
J Nat Prod
, vol.43
, pp. 736-738
-
-
Brochmann-Hanssen, E.1
Chen, C.Y.2
Linn, E.E.3
-
41
-
-
84877245681
-
De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis
-
(In Press) DOI 10.1371/journal.pone.0062714
-
Gupta P, Goel R, Pathak S, Srivastava A, Singh SP, et al. (2013) De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis. PLOS ONE (In Press) DOI: 10.1371/journal.pone.0062714.
-
(2013)
PLOS ONE
-
-
Gupta, P.1
Goel, R.2
Pathak, S.3
Srivastava, A.4
Singh, S.P.5
|