Origins of increased airway smooth muscle mass in asthma

BMC Medicine

Volumn 11, Issue 1, 2013, Pages

  Berair, Rachid ^a   Saunders, Ruth ^a   Brightling, Christopher E ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Airway remodeling; Airway smooth muscle; Asthma; Fibrocytes; Mesenchymal stem cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD11B ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; ENDOTHELIN 1; MICROSOMAL AMINOPEPTIDASE; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN;

AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE; ASTHMA; BASEMENT MEMBRANE; BRONCHUS BIOPSY; CELL ACTIVATION; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HYPERPLASIA; LUNG FIBROBLAST; LUNG FIBROSIS; MESENCHYMAL STEM CELL; MUSCLE MASS; PATHOGENESIS; RESPIRATORY TRACT INFLAMMATION; SHORT SURVEY; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; TH2 CELL; THICKNESS; WOUND HEALING;

AIRWAY REMODELING; ANIMALS; ASTHMA; HUMANS; HYPERPLASIA; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RESPIRATORY MUCOSA; UP-REGULATION;

EID: 84878492702     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-11-145     Document Type: Short Survey

References (52)

1. Busse WW, Lemanske RF. Asthma. N Engl J Med 2001, 344:350-362. 10.1056/NEJM200102013440507, 11172168.
2. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008, 31:143-178. 10.1183/09031936.00138707, 18166595.
3. Bousquet J, Mantzouranis E, Cruz AA, Ait-Khaled N, Baena-Cagnani CE, Bleecker ER, Brightling CE, Burney P, Bush A, Busse WW, Casale TB, Chan-Yeung M, Chen R, Chowdhury B, Chung KF, Dahl R, Drazen JM, Fabbri LM, Holgate ST, Kauffmann F, Haahtela T, Khaltaev N, Kiley JP, Masjedi MR, Mohammad Y, O'Byrne P, Partridge MR, Rabe KF, Togias A, van Weel C, Wenzel S, Zhong N, Zuberbier T. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010, 126:926-938. 10.1016/j.jaci.2010.07.019, 20926125.
4. Siddiqui S, Sutcliffe A, Shikotra A, Woodman L, Doe C, McKenna S, Wardlaw A, Bradding P, Pavord I, Brightling C. Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol 2007, 120:813-819. 10.1016/j.jaci.2007.05.028, 17610943.
5. Zhou C, Yin G, Liu J, Liu X, Zhao S. Epithelial apoptosis and loss in airways of children with asthma. J Asthma 2011, 48:358-365. 10.3109/02770903.2011.565848, 21504350.
6. James AL, Elliot JG, Jones RL, Carroll ML, Mauad T, Bai TR, Abramson MJ, McKay KO, Green FH. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med 2012, 185:1058-1064. 10.1164/rccm.201110-1849OC, 22403800.
7. Bai TR, Knight DA. Structural changes in the airways in asthma: observations and consequences. Clin Sci (Lond) 2005, 108:463-477.
8. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003, 167:1360-1368. 10.1164/rccm.200209-1030OC, 12531777.
9. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993, 74:2771-2781. 10.1063/1.354625, 8365980.
10. Kariyawasam HH, Aizen M, Barkans J, Robinson DS, Kay AB. Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma. Am J Respir Crit Care Med 2007, 175:896-904. 10.1164/rccm.200609-1260OC, 17272787.
11. Kuo C, Lim S, King NJ, Bartlett NW, Walton RP, Zhu J, Glanville N, Aniscenko J, Johnston SL, Burgess JK, Black JL, Oliver BG. Rhinovirus infection induces expression of airway remodelling factors in vitro and in vivo. Respirology 2011, 16:367-377. 10.1111/j.1440-1843.2010.01918.x, 21199160.
12. Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, Holgate S, Davies DE, Howarth PH. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med 2011, 364:2006-2015. 10.1056/NEJMoa1014350, 21612469.
13. Saglani S, Payne DN, Zhu J, Wang Z, Nicholson AG, Bush A, Jeffery PK. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007, 176:858-864. 10.1164/rccm.200702-212OC, 17702968.
14. O'Reilly R, Ullmann N, Irving S, Bossley CJ, Sonnappa S, Zhu J, Oates T, Banya W, Jeffery PK, Bush A, Saglani S. Increased airway smooth muscle in preschool wheezers who have asthma at school age. J Allergy Clin Immunol 2013, 131:1024-1032. 10.1016/j.jaci.2012.08.044, 23069488.
15. Bossley CJ, Fleming L, Gupta A, Regamey N, Frith J, Oates T, Tsartsali L, Lloyd CM, Bush A, Saglani S. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol 2012, 129:974-982.e13. 10.1016/j.jaci.2012.01.059, 3381727, 22385633.
16. Cokugras H, Akcakaya N, Seckin, Camcioglu Y, Sarimurat N, Aksoy F. Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma. Thorax 2001, 56:25-29. 10.1136/thorax.56.1.25, 1745903, 11120900.
17. Mitzner W. Airway smooth muscle: the appendix of the lung. Am J Respir Crit Care Med 2004, 169:787-790. 10.1164/rccm.200312-1636PP, 14742304.
18. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004, 169:1001-1006. 10.1164/rccm.200311-1529OC, 14726423.
19. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, Burgess JK, Black JL. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001, 164:474-477. 10.1164/ajrccm.164.3.2010109, 11500353.
20. Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D, Ousova O, Vernejoux JM, Marthan R, Tunon-de-Lara JM, Berger P. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med 2007, 204:3173-3181. 10.1084/jem.20070956, 2150973, 18056286.
21. Ward JE, Harris T, Bamford T, Mast A, Pain MC, Robertson C, Smallwood D, Tran T, Wilson J, Stewart AG. Proliferation is not increased in airway myofibroblasts isolated from asthmatics. Eur Respir J 2008, 32:362-371. 10.1183/09031936.00119307, 18353854.
22. Kaur D, Hollins F, Saunders R, Woodman L, Sutcliffe A, Cruse G, Bradding P, Brightling C. Airway smooth muscle proliferation and survival is not modulated by mast cells. Clin Exp Allergy 2010, 40:279-288. 10.1111/j.1365-2222.2009.03423.x, 2821816, 20030664.
23. Begueret H, Berger P, Vernejoux JM, Dubuisson L, Marthan R, Tunon-de-Lara JM. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007, 62:8-15. 10.1136/thx.2006.062141, 2111285, 17189531.
24. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994, 1:71-81. 2229929, 8790603.
25. Blakaj A, Bucala R. Fibrocytes in health and disease. Fibrogenesis Tissue Repair 2012, 5:S6. 10.1186/1755-1536-5-6, 3368795, 23259722.
26. Herzog EL, Bucala R. Fibrocytes in health and disease. Exp Hematol 2010, 38:548-556. 10.1016/j.exphem.2010.03.004, 3136351, 20303382.
27. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001, 166:7556-7562.
28. Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004, 36:598-606. 10.1016/j.biocel.2003.10.005, 15010326.
29. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003, 171:380-389.
30. Nihlberg K, Larsen K, Hultgardh-Nilsson A, Malmstrom A, Bjermer L, Westergren-Thorsson G. Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?. Respir Res 2006, 7:50. 10.1186/1465-9921-7-50, 1458331, 16571120.
31. Wang CH, Huang CD, Lin HC, Lee KY, Lin SM, Liu CY, Huang KH, Ko YS, Chung KF, Kuo HP. Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med 2008, 178:583-591. 10.1164/rccm.200710-1557OC, 18583572.
32. Wang CH, Huang CD, Lin HC, Huang TT, Lee KY, Lo YL, Lin SM, Chung KF, Kuo HP. Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J Allergy Clin Immunol 2012, 129:1367-1376. 10.1016/j.jaci.2012.01.038, 22325070.
33. Saunders R, Siddiqui S, Kaur D, Doe C, Sutcliffe A, Hollins F, Bradding P, Wardlaw A, Brightling CE. Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol 2009, 123:376-384. 10.1016/j.jaci.2008.10.048, 19081612.
34. Gomperts BN, Strieter RM. Fibrocytes in lung disease. J Leukoc Biol 2007, 82:449-456. 10.1189/jlb.0906587, 17550974.
35. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004, 114:438-446. 484979, 15286810.
36. Bianchetti L, Marini MA, Isgro M, Bellini A, Schmidt M, Mattoli S. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. Biochem Biophys Res Commun 2012, 426:116-121. 10.1016/j.bbrc.2012.08.047, 22921786.
37. Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med 2006, 174:1179-1188. 10.1164/rccm.200603-394OC, 16959919.
38. Foronjy R, Majka S. The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues. Cells 2012, 1:874-885. 10.3390/cells1040874, 3634590, 23626909.
39. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008, 8:726-736. 10.1038/nri2395, 19172693.
40. Sato K, Ozaki K, Mori M, Muroi K, Ozawa K. Mesenchymal stromal cells for graft-versus-host disease: basic aspects and clinical outcomes. J Clin Exp Hematop 2010, 50:79-89. 10.3960/jslrt.50.79, 21123965.
41. Kapoor S, Patel SA, Kartan S, Axelrod D, Capitle E, Rameshwar P. Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy-induced asthma. J Allergy Clin Immunol 2012, 129:1094-1101. 10.1016/j.jaci.2011.10.048, 22196773.
42. Ionescu LI, Alphonse RS, Arizmendi N, Morgan B, Abel M, Eaton F, Duszyk M, Vliagoftis H, Aprahamian TR, Walsh K, Thebaud B. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol 2012, 46:207-216. 10.1165/rcmb.2010-0391OC, 3361359, 21903873.
43. Tzouvelekis A, Ntolios P, Bouros D. Stem cell treatment for chronic lung diseases. Respiration 2013, 85:179-192. 10.1159/000346525, 23364286.
44. Popova AP, Bozyk PD, Bentley JK, Linn MJ, Goldsmith AM, Schumacher RE, Weiner GM, Filbrun AG, Hershenson MB. Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia. Pediatrics 2010, 126:e1127-e1133. 10.1542/peds.2009-3445, 20937656.
45. Walker N, Badri L, Wettlaufer S, Flint A, Sajjan U, Krebsbach PH, Keshamouni VG, Peters-Golden M, Lama VN. Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts. Am J Pathol 2011, 178:2461-2469. 10.1016/j.ajpath.2011.01.058, 3124120, 21641374.
46. Bentley JK, Popova AP, Bozyk PD, Linn MJ, Baek AE, Lei J, Goldsmith AM, Hershenson MB. Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype. Respir Res 2010, 11:127. 10.1186/1465-9921-11-127, 2949728, 20858250.
47. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009, 119:1420-1428. 10.1172/JCI39104, 2689101, 19487818.
48. de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lambrecht BN, Braunstahl GJ. Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation. Can J Physiol Pharmacol 2008, 86:105-112. 10.1139/Y08-004, 18418437.
49. Heijink IH, Postma DS, Noordhoek JA, Broekema M, Kapus A. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am J Respir Cell Mol Biol 2010, 42:69-79. 10.1165/rcmb.2008-0449OC, 19372245.
50. Johnson JR, Roos A, Berg T, Nord M, Fuxe J. Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. PLoS One 2011, 6:e16175. 10.1371/journal.pone.0016175, 3024415, 21283768.
51. Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Stick SM, Bai TR, Knight DA. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009, 180:122-133. 10.1164/rccm.200811-1730OC, 19406982.
52. Cox PG, Miller J, Mitzner W, Leff AR. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J 2004, 24:659-663. 10.1183/09031936.04.00054604, 15459147.