High-resolution MS: First choice for peptide quantification?

Bioanalysis

Volumn 5, Issue 10, 2013, Pages 1145-1148

  Dillen, Lieve ^a   Cuyckens, Filip ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

HRMS; orthogonal assay; peptides; quantification; SRM

Indexed keywords

PEPTIDE;

AMINO ACID COMPOSITION; ELECTROSPRAY MASS SPECTROMETRY; IMMUNOASSAY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PROCESS OPTIMIZATION; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; PROTEOMICS;

EID: 84878491075     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.90     Document Type: Review

References (11)

1. Ramigiri S, Garofolo F. Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges. Bioanalysis 4(5), 529-540 (2012).
2. Dillen L, Cools W, VereykenL et al. Comparison of triple quadrupole and high resolution time of fight mass spectrometry for quantifcation of peptides. Bioanalysis 4(3), 565-579 (2012).
3. Korfmacher W. High resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures. Bioanalysis 3 (11), 1169-71 (2011).
4. Ramanathan R, Jemal M, Ramagiri S et al. It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. J. Mass Spectrom. 46, 595-601 (2011).
5. Iavarone AT, Jurchen JC, Williams ER. Effects of solvent on the maximum charge state and charge state distribution of protein ions produced by electrospray ionization. J. Am. Soc. Mass. Spectrom. 11(11), 976-985 (2000).
6. Morin L-P, Mess J-N, Garofolo F. Large-molecule quantifcation: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF. Bioanalysis 5 (10), 1181-1193 (2013).
7. Campbell JL, Le Blanc JCY. Targeted ion parking for the quantitation of biotherapeutic proteins: concepts and preliminary data. J. Am. Soc. Mass Spectrom. 21(12), 2011-2022 (2010).
8. Hao C, Campbell JL, Verkerk UH, Le Blanc JCY, Siu KWM. Performance and attributes of liquid chromatography-mass spectrometry with targeted charge separation in quantitative analysis of therapeutic peptides. J. Am. Soc. Mass Spectrom. 22(1), 67-74 (2011).
9. Cuyckens F, Dillen L, Cools W et al. Extracting metabolite ions of peptide drugs from an in vivo matrix background. Bioanalysis 4(3), 595-604 (2012).
10. Timmerman P, Henderson N, Smeraglia J et al. Managing scientifc, technical and regulatory innovation in regulated bioanalysis: a discussion paper from the European Bioanalytical Forum. Bioanalysis 5(2), 139-145 (2013).
11. Rochat B, Kottelat E, McMullen J. The future key role of LC-high-resolution-MS analyses in clinical laboratories: a focus on quantifcation. Bioanalysis 4(24), 2939-2958 (2012).